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Principal Scientist Jobs

88 Job Offers

Principal Scientist - Purification Chemist
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Principal Scientist – Purification Chemist opportunity in Rahway, NJ, with Parexel FSP. Apply chromatography, organic chemistry, and biochemistry expertise to purify APIs and intermediates in an R&D lab. Requires semi-preparative purification experience and strong problem-solving skills. Enjoy fu...
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Principal Applied Scientist - CoreAI
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142800.00 - 304200.00 USD / Year
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Principal Associate, Data Scientist - Bank Operations Data Science
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Join Capital One as a Principal Associate Data Scientist in McLean, VA, driving data-driven innovation in Bank Operations. Leverage Python, Snowflake, and machine learning to optimize call center processes through summarization and automation. Requires a quantitative degree (BS+5 years, MS+3, or ...
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161800.00 - 184600.00 USD / Year
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Principal Environmental Scientist / Engineer (Contaminated Land)
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Lead contaminated land projects in Perth as a Principal Environmental Scientist/Engineer. Drive strategic solutions, mentor teams, and manage complex site investigations with 10+ years of experience. Enjoy flexible work-from-home options, purchased leave, and competitive benefits. Join a supporti...
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Principal Applied Scientist
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Join the Agentic Automated Reasoning Group as a Principal Applied Scientist in Boston, Austin, Santa Clara, or Portland. Leverage expertise in interactive theorem proving, deductive verification, and generative AI to build next-gen software verification tools. Requires a PhD, 10+ years in formal ...
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United States, Boston, Austin, Santa Clara, Portland
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Principal Applied Scientist (Multiple Openings) - Copilot and Agents Core
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Join Microsoft as a Principal Applied Scientist on the Copilot and Agents Core team in Redmond. You will design and develop large language models (LLMs) to revolutionize enterprise productivity. We seek experts with a PhD or Master’s in Computer Science or related field and proven research experi...
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142800.00 - 304200.00 USD / Year
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Process Development Principal Scientist
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Lead analytical development for late-phase clinical programs at Amgen in Cambridge, MA. As a Process Development Principal Scientist, you will define control strategies, drive method optimization, and support cGMP manufacturing. Requires a PhD with 3+ years industry experience in small molecule a...
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141836.95 - 191897.05 USD / Year
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Principal Data Scientist
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Principal Data Scientist role at Microsoft AI in Redmond, driving analytics for MSN & Copilot Discover. Leverage AI and machine learning to build forecasting models, analyze user engagement and monetization, and shape product strategy. Requires a Doctorate or Master’s in Data Science or related f...
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142800.00 - 274800.00 USD / Year
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Principal Data Scientist
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Join Microsoft Advertising as a Principal Data Scientist in Redmond, WA. You will solve complex marketplace challenges, define metrics, and design experiments to drive data-informed decisions. We seek a PhD or Master’s in Data Science, Statistics, or related field with deep experience in statisti...
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142800.00 - 274800.00 USD / Year
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Principal Data Scientist - AI & ML
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Senior Data Engineer sought for a Bangalore-based role. You will build governed data products using Apache Iceberg, develop scalable ETL/ELT pipelines, and implement data validation and lineage. Requires 5–8 years of experience with Python, SQL, and AWS Data Services. Ideal for experts in Data La...
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Principal Applied Scientist
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Lead the future of AI speech as a Principal Applied Scientist at Microsoft Azure Speech in Hyderabad. Drive multilingual model development, AOAI finetuning, and multimodal generative AI for voice agents and transcription. Requires 10+ years in ML/speech, Python/C++, and a PhD/MS. Impact billions ...
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Principal Data Scientist
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Join Microsoft’s ISE team as a Principal Data Scientist and solve complex customer challenges using cloud-based solutions. You’ll oversee data acquisition, coach engineers, and drive best practices for scalable models. Requires a Doctorate/Master’s/Bachelor’s in Data Science or related field with...
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United States, Multiple Locations
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142800.00 - 274800.00 USD / Year
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Senior Applied Scientist and Principal Applied Scientist
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Join Microsoft’s Core AI Speech Group in Redmond as a Senior or Principal Applied Scientist. Drive innovation in end-to-end speech modeling, deep learning, and multimodal integration with LLMs. Requires a PhD/MS in CS, EE, or related field with experience in statistics and predictive analytics. I...
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119800.00 USD / Year
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Principal Applied Scientist
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Join Microsoft AI as a Principal Applied Scientist in Redmond, WA, to build the next-generation data platform for Bing and LLM training. You will translate research into production, driving industry-wide impact with state-of-the-art modeling at internet scale. Requires a PhD/ Master’s in CS or re...
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165600.00 - 296400.00 USD / Year
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Principal Scientist - Toxicology
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Principal Scientist - Toxicology role in Vancouver, Canada. Lead nonclinical safety strategy for biologics, designing GLP/non-GLP studies for IND, CTA, and BLA submissions. Requires PhD +8 years or MSc +12 years in toxicology, deep FDA/ICH/EMA regulatory knowledge, and CRO management. Enjoy equit...
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134000.00 - 168000.00 CAD / Year
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Principal Data Scientist
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Join Microsoft AI as a Principal Data Scientist in Redmond, WA, to drive growth for Copilot Discover. You will build metrics systems, analyze big data, and design A/B tests to enhance personalized AI content. Requires a PhD/ Master’s in a quantitative field with 5+ years of data science experienc...
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139900.00 - 274800.00 USD / Year
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Principal Applied Scientist
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Join Azure AI’s GenAI Systems team as a Principal Applied Scientist in Hyderabad. Lead the development of customized LLM solutions, focusing on fine-tuning, distillation, and synthetic data generation. Requires 10+ years in ML, a PhD/Master’s in CS/AI, and expertise in Python, PyTorch, and transf...
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Principal, Data Scientist
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Principal Data Scientist role at Walmart Global Tech in Sunnyvale, CA. Architect and deploy end-to-end ML systems for reliability engineering, leveraging Python, PyTorch, and Kubernetes. Requires 10+ years building production ML, anomaly detection, and scalable model serving. Benefits include 401...
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143000.00 - 286000.00 USD / Year
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Principal Data Scientist
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Join Microsoft’s Industry Solutions Engineering team as a Principal Data Scientist in Houston, TX. Leverage your PhD or Master’s in Data Science to drive cloud-based innovation, coach engineers, and develop scalable operational models. Lead data acquisition, ethics, and best practices while solvi...
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142800.00 - 274800.00 USD / Year
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Principal Applied Scientist
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Lead causal inference and attribution science as a Principal Applied Scientist in Redmond. Drive data-driven measurement, incrementality estimation, and counterfactual learning for web-scale advertising systems. Requires a PhD/ Master’s in CS, Statistics, or related field with 3-9+ years experien...
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142800.00 - 274800.00 USD / Year
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About the Principal Scientist role

A Principal Scientist is a senior-level research and development leader who drives innovation by designing, building, and deploying advanced machine learning and artificial intelligence systems at scale. These professionals typically operate at the intersection of theoretical research and practical engineering, translating complex scientific concepts into production-ready solutions that power core business products and user experiences. Principal Scientist jobs are distinguished by their emphasis on strategic technical leadership, cross-functional collaboration, and high-impact problem solving.

The core responsibilities of a Principal Scientist often include architecting large-scale ML and deep learning pipelines, developing novel model architectures for ranking, recommendation, personalization, and generative AI systems. They are responsible for defining evaluation frameworks, designing experiments, and establishing metrics that accurately measure both system performance and user value. A significant portion of the role involves mentoring junior scientists and engineers, setting technical standards, and driving alignment across product, engineering, and data science teams. Principal Scientists also lead the integration of cutting-edge techniques such as large language models (LLMs), retrieval-augmented generation, agentic systems, and multi-objective optimization into existing infrastructure. They regularly communicate complex technical strategies to diverse stakeholders and act as trusted advisors on data-driven decision making.

Typical skills and requirements for Principal Scientist positions include an advanced degree (PhD or Master’s) in computer science, statistics, mathematics, operations research, or a related quantitative field, combined with extensive experience—often six to ten years or more—delivering production ML systems. Deep expertise in recommendation systems, search relevance, natural language processing, or generative AI is common. Proficiency in modern ML frameworks (e.g., PyTorch, TensorFlow), large-scale data processing (e.g., Spark), and cloud infrastructure is essential. Strong architectural skills for designing distributed, high-throughput services are critical, as is a solid publication record in top-tier conferences (e.g., NeurIPS, KDD, ICML, RecSys). Beyond technical depth, these roles demand exceptional communication, mentorship, and strategic influence abilities. Principal Scientist jobs are ideal for individuals who thrive on solving ambiguous, high-stakes challenges and driving measurable impact through scientific innovation and technical leadership.