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Principal Scientist Jobs

152 Job Offers

Principal Downstream Scientist – mRNA purification
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Lead mRNA purification process development for innovative vaccines in Cambridge, US. This principal role requires a PhD/Master's with 3-5+ years of downstream experience (affinity, IEX). Design scalable processes, drive CMC activities, and collaborate cross-functionally. Competitive salary, bonus...
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United States , Cambridge
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115500.00 - 192500.00 USD / Year
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GSK
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Principal Data Scientist
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Lead the next wave of data-driven disruption as a Principal Data Scientist at Capital One. You will build advanced machine learning models using Python and Snowflake to optimize enterprise payments. This role requires a quantitative degree and experience in data analytics. Join a collaborative te...
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United States , McLean; Richmond
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147100.00 - 184600.00 USD / Year
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Capital One
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Principal Applied Scientist
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Lead the next generation of intelligent ad recommender systems at Microsoft Advertising in Bangalore. Apply deep expertise in large-scale ML, retrieval, ranking, and LLMs to high-impact, real-world problems. Drive technical strategy, mentor teams, and ship models that shape the future of digital ...
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India , Bangalore
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Not provided
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Microsoft Corporation
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Principal Data Scientist
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Lead high-impact cloud solutions for capital markets as a Principal Data Scientist at Microsoft. Collaborate directly with financial services clients to develop innovative, scalable code and data models. This global role requires deep industry expertise and experience with strict compliance stand...
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United States , Multiple Locations
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Join Microsoft's AI Web Data team as a Principal Applied Scientist in Redmond. Build the next-gen data platform powering Bing and LLM training at internet scale. Apply your deep research expertise in statistics or computer science to translate cutting-edge models into production. Drive industry-w...
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Scientist, Microbiologist
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Join GSK as a Principal Scientist, Microbiologist in Upper Merion or Marietta, PA. Provide vital sterility assurance and contamination control support for sterile manufacturing R&D. Utilize your expertise in environmental monitoring, bioburden, and endotoxin testing within GMP standards. Enjoy co...
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United States , King of Prussia; Upper Merion; Marietta
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Not provided
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GSK
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Principal Data Scientist
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Lead the next wave of data-driven disruption as a Principal Data Scientist at Capital One. You will build advanced machine learning models using Python, AWS, and Spark on billions of customer records. This role requires a quantitative degree and 5+ years of experience. Join a cross-functional tea...
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United States , McLean; New York; Richmond
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147100.00 - 201400.00 USD / Year
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Capital One
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Principal Applied Scientist
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Join Microsoft's Feeds and AI team in Beijing to shape the future of content discovery on Microsoft Start. As a Principal Applied Scientist, you will develop and optimize cutting-edge recommender systems and ranking algorithms. Leverage your expertise in machine learning, generative AI, and data ...
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China , Beijing
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Not provided
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Microsoft Corporation
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Principal Applied Scientist - Auction & Bidding
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Lead auction and bidding strategy as a Principal Applied Scientist at Microsoft Advertising in Redmond. Design and optimize real-time ad auctions using machine learning, game theory, and advanced statistics. Requires 8+ years of production system experience and 3+ years in auto-bidding or auction...
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Senior Applied Scientist and Principal Applied Scientist
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Join Microsoft's productivity division to shape the future of work with AI. As a Senior or Principal Applied Scientist, you will drive research from concept to products like M365 Copilot and Dynamics 365. This role requires a strong publication record and offers the chance to publish at top-tier ...
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United States , Multiple Locations
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119800.00 - 234700.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Lead complex, high-impact customer engagements as a Principal Data Scientist at Microsoft. Translate ambiguous business challenges into scalable data science solutions and strategic roadmaps. This global role requires deep technical expertise in modeling, evaluation frameworks, and responsible AI...
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United States , Multiple Locations
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Staff / Principal Research Scientist
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Join Inworld's product-oriented AI research lab in the UK. We seek a Staff/Principal Research Scientist with a PhD or equivalent experience in foundation models, multimodal AI, and evaluation. You will own full-stack research, from framing questions to shipping results, in a flat-structure, high-...
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United Kingdom
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140000.00 - 200000.00 GBP / Year
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Inworld AI
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Principal Applied Scientist
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Lead AI-driven security innovation as a Principal Applied Scientist in Bangalore. Develop agentic systems for automated threat discovery, leveraging 10+ years in data analysis, Python/C#, and cloud platforms. Transform telemetry into proactive defenses, specializing in Linux/macOS and collaborati...
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India , Bangalore
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Not provided
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Microsoft Corporation
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R&D FSQA Associate Principal Scientist
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Lead end-to-end food safety risk assessment for beverage ingredients at PepsiCo in Valhalla, NY. This senior role requires 10+ years in Food Safety, HACCP/PCQI certification, and expertise in biological, chemical, and physical hazard analysis. Apply your project management skills within a global ...
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United States , Valhalla
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123802.00 - 135000.00 USD / Year
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The New York Times
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Principal Applied Scientist
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Lead the development of cutting-edge LLMs for Microsoft 365 Copilot as a Principal Applied Scientist. You will design AI subsystems, collaborate with research and engineering teams, and drive strategic solutions. This role requires a strong background in computer science or a related field and ex...
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United States , Multiple Locations
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist – AI & Machine Learning
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Principal Data Scientist role in London, shaping AI strategy for a leading alternative assets firm. Lead the delivery of production-grade ML and generative AI solutions, mentoring a high-performing team. Requires 6-12 years' hands-on experience, strong Python skills, and a quantitative advanced d...
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United Kingdom , London
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100000.00 - 125000.00 GBP / Year
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Myn
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Principal Data Scientist
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Join Microsoft's global ISE team in London as a Principal Data Scientist. Lead customer-facing projects, developing cloud-based AI/ML solutions and driving best practices in data science. A relevant advanced degree and significant experience in data analysis and model development are required. En...
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United Kingdom , London
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Not provided
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Microsoft Corporation
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Principal Applied Scientist
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Lead the next generation of AI-powered recommendation systems at Microsoft in Redmond. As a Principal Applied Scientist, you will architect large-scale ranking models using LLMs and agentic AI. This senior role requires deep expertise in recommendation systems, machine learning frameworks, and cl...
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United States , Redmond
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Salary
163000.00 - 296400.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Join Microsoft's Cloud Operations + Innovation team as a Principal Data Scientist. You will lead complex data science initiatives to optimize the global data center delivery lifecycle. This role requires a Master's degree and 4+ years of experience in data science, statistical modeling, and machi...
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United States , Redmond
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130900.00 - 251900.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Join Microsoft AI in Beijing as a Principal Applied Scientist. Drive E2E AI product development using state-of-the-art NLP and deep learning techniques. You will tackle core challenges in search and AIGC, transforming innovative research into production impact. This role requires 6+ years of NLP/...
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China , Beijing
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Not provided
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Microsoft Corporation
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About the Principal Scientist role

A Principal Scientist is a senior-level research and development leader who drives innovation by designing, building, and deploying advanced machine learning and artificial intelligence systems at scale. These professionals typically operate at the intersection of theoretical research and practical engineering, translating complex scientific concepts into production-ready solutions that power core business products and user experiences. Principal Scientist jobs are distinguished by their emphasis on strategic technical leadership, cross-functional collaboration, and high-impact problem solving.

The core responsibilities of a Principal Scientist often include architecting large-scale ML and deep learning pipelines, developing novel model architectures for ranking, recommendation, personalization, and generative AI systems. They are responsible for defining evaluation frameworks, designing experiments, and establishing metrics that accurately measure both system performance and user value. A significant portion of the role involves mentoring junior scientists and engineers, setting technical standards, and driving alignment across product, engineering, and data science teams. Principal Scientists also lead the integration of cutting-edge techniques such as large language models (LLMs), retrieval-augmented generation, agentic systems, and multi-objective optimization into existing infrastructure. They regularly communicate complex technical strategies to diverse stakeholders and act as trusted advisors on data-driven decision making.

Typical skills and requirements for Principal Scientist positions include an advanced degree (PhD or Master’s) in computer science, statistics, mathematics, operations research, or a related quantitative field, combined with extensive experience—often six to ten years or more—delivering production ML systems. Deep expertise in recommendation systems, search relevance, natural language processing, or generative AI is common. Proficiency in modern ML frameworks (e.g., PyTorch, TensorFlow), large-scale data processing (e.g., Spark), and cloud infrastructure is essential. Strong architectural skills for designing distributed, high-throughput services are critical, as is a solid publication record in top-tier conferences (e.g., NeurIPS, KDD, ICML, RecSys). Beyond technical depth, these roles demand exceptional communication, mentorship, and strategic influence abilities. Principal Scientist jobs are ideal for individuals who thrive on solving ambiguous, high-stakes challenges and driving measurable impact through scientific innovation and technical leadership.