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Principal Scientist Jobs

145 Job Offers

Principal Applied Scientist- M365 Copilot
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Join Microsoft’s M365 Copilot team in Beijing as a Principal Applied Scientist to build the next-gen intelligent assistant. You’ll own end-to-end design of agentic AI systems, focusing on reasoning, memory, and LLM post-training at massive scale. Ideal candidates have a PhD/advanced degree in CS ...
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China , Beijing
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Not provided
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Microsoft Corporation
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Principal Data Scientist
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Principal Data Scientist role in Bangalore, India, driving data science adoption across the organization. You will develop machine learning models, statistical analyses, and NLP solutions to extract insights from big data. Requires expertise in Python, R, data architecture, and stakeholder collab...
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India , Bangalore
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Not provided
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NTT DATA
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Principal Applied Scientist Search/NLP/IR
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Principal Applied Scientist role in Berlin driving Zalando’s search evolution using NLP, IR, and LLMs. Lead scientific roadmaps, deploy transformer-based deep learning models, and shape intent-driven, personalized search experiences. Requires PhD, 4+ years industry experience, and expertise in Py...
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Germany , Berlin
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Not provided
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Zalando Sverige
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Principal Applied Scientist
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Senior Principal Applied Scientist sought by Microsoft Advertising to lead scientific strategy for large-scale recommender and decisioning systems in Bangalore, India. Drive innovation in retrieval, relevance, and foundation-model-powered experiences across search, native, and video ads. Requires...
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India , Bangalore
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Not provided
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Microsoft Corporation
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Principal Applied Scientist
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Principal Applied Scientist sought for Ads Trust & Safety in Bangalore, India. Drive threat modeling and adversarial defense against sophisticated fraud vectors like phishing and malware. Requires 10+ years in cybersecurity, expertise in adversarial ML, and C++/Python skills. Architect dynamic, b...
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India , Bangalore
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Not provided
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Microsoft Corporation
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Principal Scientist – Ai/Ml Workflow & Ecosystem Lead (Large Molecule Discovery Informatics)
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Lead AI/ML integration for Large Molecule Discovery in Hyderabad. As Principal Scientist, you will translate advanced computational models into production-ready workflows, driving measurable impact in biologics research. Requires a PhD with 5+ years of relevant experience. Enjoy a comprehensive b...
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India , Hyderabad
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Not provided
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Amgen
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Principal Scientist - Clinical Pharmacology, Modeling and Simulation
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Principal Scientist in Clinical Pharmacology, Modeling & Simulation sought for Hyderabad, India. Drive next-gen pharmacometric analyses using AI/ML, PK/PD modeling, and advanced data workflows. Requires 8+ years experience, expertise in Python/R/NONMEM, and a track record in model-based drug deve...
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India , Hyderabad
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Amgen
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Principal Generative AI Scientist
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Principal Generative AI Scientist role in McLean, VA (onsite). Lead enterprise-grade GenAI solution design, development, and deployment for a major financial client. Requires PhD, 10+ years AI/ML experience, deep expertise in LLMs, RAG, agents, and AWS (SageMaker, Bedrock). Contract-to-hire with ...
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United States , McLean
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Salary
80.00 - 95.73 USD / Hour
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Apex Systems
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Principal Applied Scientist - Catalog/Search Ranking
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Lead the scientific roadmap for cutting-edge search and catalog ranking at Zalando in Berlin. Utilize deep learning, transformers, and reinforcement learning to personalize discovery for millions. This senior role requires a PhD and 8+ years of industry experience in large-scale ML systems. Enjoy...
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Germany , Berlin
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Zalando
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Principal Applied Scientist
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Join Microsoft’s Azure AI Foundry Agent Platform as a Principal Applied Scientist in Redmond, WA. Drive agent self-improvement by bridging research and production, leveraging RLHF and advanced AI. Requires a PhD/ Master’s in CS or related field with 3+ years of experience. Shape next-gen AI solut...
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United States , Redmond
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139900.00 - 304200.00 USD / Year
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Microsoft Corporation
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Biologics Analytical Principal Scientist
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Lead advanced analytical development for biologics (mAbs, ADCs) in Suzhou. Utilize HPLC, LC-MS, and CE for method development, validation, and CMC regulatory filings. This senior role requires 8+ years of innovator pharma experience and strong technical leadership. Drive CMC compliance and mentor...
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China , 苏州市
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300000.00 - 600000.00 CNY / Year
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Randstad
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Principal Data Scientist
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Lead the next generation of AI at Fidelity as a Principal Data Scientist in Boston. Design and deploy production-scale NLP, speech analytics, and generative AI solutions using Python and AWS. This hands-on technical leadership role offers comprehensive benefits and the chance to mentor teams whil...
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United States , Boston
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126000.00 - 255000.00 USD / Year
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Fidelity Investments
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Principal Applied Scientist
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Lead AI innovation at Microsoft as a Principal Applied Scientist in Redmond. You will design and experiment with advanced LLM inference systems and robust evaluation frameworks. This role requires a strong background in AI/ML, predictive analytics, and experience with large-scale model fine-tunin...
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Lead the development of AI/ML and GenAI solutions as a Principal Data Scientist at Amgen in Hyderabad. Leverage your deep expertise in data science, cloud platforms (AWS), and technologies like Deep Learning and NLP. Collaborate cross-functionally to build secure, scalable products that accelerat...
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India , Hyderabad
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Not provided
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Amgen
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Principal Applied Scientist Search/NLP/IR
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Join Zalando in Berlin to revolutionize fashion search as a Principal Applied Scientist. You will lead the scientific roadmap, applying cutting-edge NLP, IR, and LLMs to build intent-driven, personalized search experiences. This senior role requires a PhD, deep industry expertise in deep learning...
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Germany , Berlin
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Not provided
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Zalando
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Principal Applied Scientist
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Join Microsoft Teams as a Principal Applied Scientist in Redmond. Lead AI innovation for enterprise voice calling, applying large foundation models to enhance real-time communication and Copilot features. Collaborate cross-functionally to build intelligent, scalable solutions. Requires a relevant...
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Senior Applied Scientist and Principal Applied Scientist
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Join Microsoft's M365 Core team in Redmond as a Senior or Principal Applied Scientist. Drive transformative AI research and development, focusing on large language models and machine learning solutions for productivity and collaboration. Collaborate with top engineers and researchers to shape int...
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United States , Redmond
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Salary
119800.00 - 234700.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Join Microsoft's global Industry Solutions Engineering team as a Principal Data Scientist. Tackle customer challenges by developing scalable cloud solutions and open-source assets. This senior role requires extensive data science experience, a relevant advanced degree, and strong client-facing pr...
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United States , Multiple Locations
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Salary
139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Join Microsoft's Bing multimedia Relevance Team in Redmond as a Principal Applied Scientist. You will develop advanced search technology using computer vision, NLP, and machine learning. This role requires a strong background in ML, data mining, and a relevant advanced degree with 4+ years of exp...
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United States , Redmond
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Salary
139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Associate, Data Scientist
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Join Capital One's People Strategy & Analytics team as a Principal Associate, Data Scientist. Apply AI, machine learning, and NLP to build models that enhance HR tools and talent strategy. This McLean-based role requires a quantitative degree and experience in data analytics, using Python, SQL, A...
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United States , McLean
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Salary
161800.00 - 184600.00 USD / Year
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Capital One
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About the Principal Scientist role

A Principal Scientist is a senior-level research and development leader who drives innovation by designing, building, and deploying advanced machine learning and artificial intelligence systems at scale. These professionals typically operate at the intersection of theoretical research and practical engineering, translating complex scientific concepts into production-ready solutions that power core business products and user experiences. Principal Scientist jobs are distinguished by their emphasis on strategic technical leadership, cross-functional collaboration, and high-impact problem solving.

The core responsibilities of a Principal Scientist often include architecting large-scale ML and deep learning pipelines, developing novel model architectures for ranking, recommendation, personalization, and generative AI systems. They are responsible for defining evaluation frameworks, designing experiments, and establishing metrics that accurately measure both system performance and user value. A significant portion of the role involves mentoring junior scientists and engineers, setting technical standards, and driving alignment across product, engineering, and data science teams. Principal Scientists also lead the integration of cutting-edge techniques such as large language models (LLMs), retrieval-augmented generation, agentic systems, and multi-objective optimization into existing infrastructure. They regularly communicate complex technical strategies to diverse stakeholders and act as trusted advisors on data-driven decision making.

Typical skills and requirements for Principal Scientist positions include an advanced degree (PhD or Master’s) in computer science, statistics, mathematics, operations research, or a related quantitative field, combined with extensive experience—often six to ten years or more—delivering production ML systems. Deep expertise in recommendation systems, search relevance, natural language processing, or generative AI is common. Proficiency in modern ML frameworks (e.g., PyTorch, TensorFlow), large-scale data processing (e.g., Spark), and cloud infrastructure is essential. Strong architectural skills for designing distributed, high-throughput services are critical, as is a solid publication record in top-tier conferences (e.g., NeurIPS, KDD, ICML, RecSys). Beyond technical depth, these roles demand exceptional communication, mentorship, and strategic influence abilities. Principal Scientist jobs are ideal for individuals who thrive on solving ambiguous, high-stakes challenges and driving measurable impact through scientific innovation and technical leadership.