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Principal Scientist Jobs

155 Job Offers

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Principal Data Scientist - Rentals Shopping
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Principal Data Scientist sought to lead the Rentals Shopping pillar at Zillow, driving data strategy for the rental consumer journey. You will partner with product leadership to shape roadmaps using advanced modeling, causal inference, and experimentation at scale. Requires a PhD/Master’s, 8+ yea...
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United States , Remote-USA
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178300.00 - 284700.00 USD / Year
Zillow
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Principal Data Scientist - Rentals Marketplace Ads Team
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Join Zillow’s Rentals Marketplace Ads Team as a Principal Data Scientist. Leverage your Ph.D/Master’s and 8+ years of experience in quantitative analysis, A/B testing, and causal inference to build value-based pricing systems. Master SQL, Python, and Databricks to analyze complex datasets and dri...
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United States
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169300.00 - 284700.00 USD / Year
Zillow
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Senior Principal Applied Scientist - ZMS
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Senior Principal Applied Scientist sought to lead real-time bidding and auction optimization at Zalando Marketing Services in Berlin. Drive high-load, low-latency ML systems integrating Auction Theory and Mechanism Design. Requires a PhD, 10+ years in Ad Tech, and expertise in Python and large-sc...
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Germany , Berlin
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Not provided
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Zalando Lounge
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Principal Associate, Data Scientist - Retail Bank Valuations Data Science
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Join Capital One as a Principal Associate Data Scientist in McLean, VA, driving data-driven innovation in Retail Bank Valuations. Leverage machine learning, Python, and SQL to build scalable models that optimize marketing efficiency and business strategy. Ideal for candidates with a quantitative ...
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United States , McLean
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161800.00 - 184600.00 USD / Year
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Capital One
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Principal Optical Scientist
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Join Microsoft Research in Cambridge, UK as a Principal Optical Scientist to shape next-gen AI infrastructure. You will lead high-risk optical system design, modelling, and simulation using Zemax and Python, bridging research with production. This role requires a Doctorate in Optics or equivalent...
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United Kingdom , Cambridge
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Not provided
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Microsoft Corporation
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Principal Data Scientist
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Join Microsoft’s ISE team as a Principal Data Scientist in Atlanta. You’ll solve complex customer challenges, develop cloud-based solutions, and drive data strategy. Requires a PhD/MS in Data Science or related field with 5+ years experience. Enjoy a competitive benefits package while innovating ...
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United States , Atlanta
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist & Analytics
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Join Microsoft’s Monetization Marketplace Team as a Principal Data Scientist & Analytics leader in Redmond, WA. Drive data-driven decisions by defining metrics, designing experiments, and delivering actionable insights across engineering and product teams. Requires a PhD/Master’s in Data Science,...
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Microsoft seeks a Principal Data Scientist to drive data-driven solutions in a dynamic, cloud-enabled environment. You will partner with engineering, finance, and sales teams to transform large-scale telemetry into actionable insights, defining quota strategies and applying machine learning. Idea...
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United States , Multiple Locations
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142800.00 - 304200.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Principal Data Scientist role in the West Midlands, UK. Lead advanced analytics, machine learning, and AI solution delivery across client programmes. Requires deep expertise in statistics, model validation, and setting coding standards. Drive responsible AI practices, mentor teams, and influence ...
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United Kingdom , West Midlands
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Not provided
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AWTG
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Principal Data Scientist - AI Foundations, Specialist Models
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Lead AI innovation as a Principal Data Scientist at Capital One, driving next-gen entity resolution with Python, AWS, and Spark. Leverage cutting-edge models like transformers and graph ML, plus Agentic AI tools, to disrupt financial services. Based in McLean, San Jose, or New York, you’ll partne...
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United States , McLean; San Jose; New York
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161800.00 - 201400.00 USD / Year
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Capital One
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Principal Applied Scientist
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Join Microsoft AI as a Principal Applied Scientist in Redmond, WA, to architect next-gen recommendation systems using LLMs and GenAI. You will design deep learning ranking models and agentic systems for large-scale content feeds. Ideal for a senior leader with expertise in ML/DL pipelines and a P...
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United States , Redmond
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139900.00 - 304200.00 USD / Year
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Microsoft Corporation
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Principal Data Scientist
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Join Microsoft AI as a Principal Data Scientist in Redmond, WA, to lead content measurement strategy and drive AI-powered analytics. You’ll mentor data scientists, develop AI agents for automated deep analysis, and partner with product teams on Edge, Copilot, and Ads. Requires a PhD/MS in a quant...
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United States , Redmond
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Not provided
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Microsoft Corporation
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Principal Applied Scientist
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Join Microsoft’s Azure AI Knowledge team in Barcelona as a Principal Applied Scientist. Lead the development of agentic retrieval systems and LLM-powered query workflows for enterprise customers. You will drive research into production, build evaluation metrics, and collaborate across teams to sh...
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Spain , Barcelona
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Not provided
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Microsoft Corporation
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Principal Data Scientist
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Canada , Greater Toronto
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142400.00 - 257500.00 CAD / Year
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Microsoft Corporation
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Senior Principal Scientist – Chemical Biology & Proximity-Based Therapeutics
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Senior Principal Scientist role in Thousand Oaks, CA, leading molecular glue discovery via phenotypic screening and chemical genetics. Drive proximity-based therapeutics within Amgen’s Induced Proximity Platform. Requires a Doctorate and 3+ years in chemical biology and small molecule discovery. ...
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United States , Thousand Oaks
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162509.80 - 219866.20 USD / Year
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Amgen
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Principal, Data Scientist
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India , Chennai
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Not provided
Workday
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Principal Applied Scientist
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United States , Redmond
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163000.00 - 296400.00 USD / Year
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Microsoft Corporation
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Principal AI Scientist - Zalando Assistant
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Germany , Berlin
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Zalando Lounge
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Principal Applied Scientist- M365 Copilot
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Join Microsoft’s M365 Copilot team in Beijing as a Principal Applied Scientist to build the next-gen intelligent assistant. You’ll own end-to-end design of agentic AI systems, focusing on reasoning, memory, and LLM post-training at massive scale. Ideal candidates have a PhD/advanced degree in CS ...
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China , Beijing
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Not provided
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Microsoft Corporation
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About the Principal Scientist role

A Principal Scientist is a senior-level research and development leader who drives innovation by designing, building, and deploying advanced machine learning and artificial intelligence systems at scale. These professionals typically operate at the intersection of theoretical research and practical engineering, translating complex scientific concepts into production-ready solutions that power core business products and user experiences. Principal Scientist jobs are distinguished by their emphasis on strategic technical leadership, cross-functional collaboration, and high-impact problem solving.

The core responsibilities of a Principal Scientist often include architecting large-scale ML and deep learning pipelines, developing novel model architectures for ranking, recommendation, personalization, and generative AI systems. They are responsible for defining evaluation frameworks, designing experiments, and establishing metrics that accurately measure both system performance and user value. A significant portion of the role involves mentoring junior scientists and engineers, setting technical standards, and driving alignment across product, engineering, and data science teams. Principal Scientists also lead the integration of cutting-edge techniques such as large language models (LLMs), retrieval-augmented generation, agentic systems, and multi-objective optimization into existing infrastructure. They regularly communicate complex technical strategies to diverse stakeholders and act as trusted advisors on data-driven decision making.

Typical skills and requirements for Principal Scientist positions include an advanced degree (PhD or Master’s) in computer science, statistics, mathematics, operations research, or a related quantitative field, combined with extensive experience—often six to ten years or more—delivering production ML systems. Deep expertise in recommendation systems, search relevance, natural language processing, or generative AI is common. Proficiency in modern ML frameworks (e.g., PyTorch, TensorFlow), large-scale data processing (e.g., Spark), and cloud infrastructure is essential. Strong architectural skills for designing distributed, high-throughput services are critical, as is a solid publication record in top-tier conferences (e.g., NeurIPS, KDD, ICML, RecSys). Beyond technical depth, these roles demand exceptional communication, mentorship, and strategic influence abilities. Principal Scientist jobs are ideal for individuals who thrive on solving ambiguous, high-stakes challenges and driving measurable impact through scientific innovation and technical leadership.