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Senior Systems Engineer United States Jobs (On-site work)

133 Job Offers

Senior Systems Engineer
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Senior Systems Engineer needed in Brooklyn to design and support hybrid cloud and on-premises infrastructure. You will manage virtualization, enterprise storage, and networking across Azure, AWS, and Cisco platforms. Strong skills in automation, monitoring (NinjaOne), and high-availability soluti...
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Robert Half
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Senior Systems Administrator / Infrastructure Engineer
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Senior Systems Administrator / Infrastructure Engineer needed in Birmingham, AL. Leverage 5+ years of VMware and Windows Server expertise to ensure enterprise infrastructure stability and performance. This role focuses on virtualization, disaster recovery, and providing white-glove support. Enjoy...
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Robert Half
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Senior Systems Engineer, AM&D Services & Products
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Senior Systems Engineer sought for Uber’s Autonomous Mobility & Delivery Safety team in San Francisco, Seattle, or New York. You will define safety frameworks and V&V strategies (ISO 26262, SOTIF) for complex AV integrations. Requires 7+ years in systems engineering with hardware/software focus a...
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United States, New York, NY, Seattle, WA, San Francisco, CA
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171000.00 - 190000.00 USD / Year
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Uber
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Senior Legacy Systems Engineer
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Senior Legacy Systems Engineer needed to support USAF logistics and maintenance systems at Maxwell AFB. Requires 10+ years of legacy application support, COBOL, mainframe integration, and active Secret clearance. Lead modernization, refactoring, and coexistence of mission-critical IMDS/IMDS-MSM c...
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BlueWater Federal Solutions
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Senior Software Engineer, Knowledge Graph/Entity Systems - Microsoft AI Search
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Senior Software Engineer, Knowledge Graph/Entity Systems – Microsoft AI Search in Mountain View, CA. Design and develop AI-powered systems for entity extraction, enrichment, and understanding using machine learning and LLMs. Solve complex challenges in entity resolution and knowledge acquisition ...
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119800.00 - 234700.00 USD / Year
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Microsoft Corporation
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Senior Electrical Engineer - Power Systems
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Senior Electrical Engineer sought for Amgen’s Holly Springs site to lead capital project electrical design and commissioning. You will steer planning, equipment selection, and construction support for process and utility systems. Requires a Bachelor’s degree with 4 years of engineering experience...
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115494.60 - 156257.40 USD / Year
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Amgen
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Senior Hardware Systems Engineer
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Senior Hardware Systems Engineer sought by Crusoe, a vertically integrated AI infrastructure company. Drive the full hardware lifecycle for high-performance compute platforms, leveraging 8+ years of experience in PCIe, InfiniBand, and NVMe debugging. Based in San Francisco, this role offers compe...
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172000.00 - 209000.00 USD / Year
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Crusoe
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Senior Lead Software Engineer, Distributed Systems (Golang + Python on Kubernetes)
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Senior Lead Software Engineer sought by Capital One to drive AI/ML transformation in San Francisco. You will lead a team building distributed systems using Golang, Python, and Kubernetes on AWS. Requires 6+ years in software engineering and cloud expertise. Join a collaborative team pioneering Ge...
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United States, San Francisco, CA
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229900.00 - 286200.00 USD / Year
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Capital One
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Senior Manufacturing Systems Engineer: Automation
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Join Amgen as a Senior Manufacturing Systems Engineer: Automation in Holly Springs, NC. You will develop and maintain Emerson DeltaV DCS for our advanced FleXbatch facility. Ideal candidates have a degree in Engineering and GMP biopharmaceutical automation experience. Enjoy a comprehensive benefi...
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Amgen
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Senior Manufacturing Systems Engineer: Automation (Wednesday - Saturday Shift)
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Join Amgen’s cutting-edge Holly Springs facility as a Senior Manufacturing Systems Engineer (Automation) on a Wednesday-Saturday shift. You’ll develop and maintain Emerson DeltaV DCS systems, transforming process requirements into digital solutions in a GxP environment. Ideal candidates bring 4+ ...
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136906.95 - 185227.05 USD / Year
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Amgen
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Senior Radar Systems Engineer
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Senior Radar Systems Engineer needed in Dahlgren, VA to support the AN/SPY-6 radar program. Requires a Bachelor’s in Engineering, Math, or Physics with 10+ years of Surface Navy Radar and Combat Systems experience. Key duties include System Engineering Technical Reviews, Aegis/SSDS integration, a...
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100.00 - 110.00 USD / Hour
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Astrion
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Senior Robotic Systems Integration Engineer (SLA & SLS)
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Senior Robotic Systems Integration Engineer (SLA & SLS) sought in Somerville, MA. You will lead the integration of firmware and hardware, guiding prototypes through development to optimize complex electro-mechanical systems. Requires 3+ years designing such systems, expertise in motion control, s...
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130000.00 - 163000.00 USD / Year
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Formlabs GmbH
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Senior Robotic Systems Integration Engineer (SLA & SLS)
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Senior Robotic Systems Integration Engineer (SLA & SLS) sought by Formlabs in Boston to lead electro-mechanical system design and integration for groundbreaking 3D printers. You will manage subsystem requirements, define control algorithms, and resolve cross-disciplinary issues using Python or La...
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130000.00 - 163000.00 USD / Year
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Formlabs GmbH
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About the Senior Systems Engineer role

Explore Senior Systems Engineer Jobs and discover a pivotal career at the intersection of deep technical expertise and strategic project leadership. Senior Systems Engineers are the architectural backbone of complex technological initiatives, responsible for designing, integrating, and maintaining sophisticated systems that form the core infrastructure of modern organizations. This role transcends singular disciplines, requiring a holistic approach to ensure that all system components—whether hardware, software, or network—work seamlessly together to meet business and performance objectives.

Professionals in these senior roles typically bear the responsibility for the entire systems lifecycle. They analyze requirements, architect robust solutions, and oversee implementation and deployment. A core duty involves troubleshooting high-level issues, performing root cause analysis, and ensuring system reliability, security, and scalability. They act as critical liaisons, translating business needs into technical specifications and guiding cross-functional teams of developers, network administrators, and other engineers. Furthermore, Senior Systems Engineers are often tasked with establishing best practices, creating documentation, mentoring junior staff, and driving continuous improvement through automation and process refinement.

The skill set for these jobs is both broad and deep. A strong foundation in systems theory is essential, coupled with expertise in specific domains such as cloud platforms (AWS, Azure, GCP), virtualization, scripting and automation (Python, Bash, PowerShell), and infrastructure as code (Terraform, Ansible). Proficiency in monitoring and observability tools is crucial for maintaining system health. Beyond technical prowess, successful candidates demonstrate exceptional problem-solving abilities, project management skills, and clear communication to interact effectively with both technical teams and stakeholders. Typically, employers seek candidates with a bachelor’s degree in computer science, engineering, or a related field, supplemented by several years of hands-on systems engineering experience, with a proven track record in designing and managing complex, scalable environments.

Senior Systems Engineer jobs represent a career path for seasoned technical professionals ready to take on architectural ownership and strategic influence. These positions are found across every industry, from finance and healthcare to technology and manufacturing, offering the opportunity to build and sustain the critical systems that power innovation and operational excellence. If you are a systems thinker with a passion for integration, optimization, and leadership, exploring Senior Systems Engineer roles could be your next career milestone.