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Senior Systems Engineer United States Jobs (On-site work)

128 Job Offers

Senior Systems Verification Engineer
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Senior Systems Verification Engineer sought by Baxter in Round Lake, IL to drive life-saving medical device testing. Leverage 3+ years of experience in FDA/ISO standards, design controls, and MTBF analysis to develop system verification deliverables. Collaborate on infusion system validation, IQ/...
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Location
United States , Round Lake
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Salary
96000.00 - 132000.00 USD / Year
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Baxter
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Senior Systems Verification Engineer
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Senior Systems Verification Engineer sought in Round Lake, IL to lead life-saving medical device testing. Leverage 3+ years of experience in ISO/FDA standards, design controls, and MTBF analysis. Drive system verification, validation, and traceability for infusion technologies. Enjoy robust benef...
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Location
United States , Round Lake
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Salary
96000.00 - 132000.00 USD / Year
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Baxter
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Systems Engineer, Senior
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Senior Systems Engineer needed to support AFLCMC/HB at Hanscom AFB, MA. Requires a Bachelor’s degree, 10+ years of experience (5 in DoD), and an active Secret clearance. Key skills include Model Based Systems Engineering, requirements development, and DoD acquisition processes. Enjoy a robust ben...
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Location
United States , Bedford
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Salary
90220.00 - 130000.00 USD / Year
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DCS Corporation
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Senior Systems Verification Engineer
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Senior Systems Verification Engineer sought for life-saving medical device development at Round Lake, IL. Leverage 3+ years of experience in Mechanical, Electrical, or Biomedical Engineering to lead system verification, test planning, and regulatory compliance (ISO/FDA). Drive quality through des...
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Location
United States , Round Lake
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Salary
96000.00 - 132000.00 USD / Year
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Baxter
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Senior MBSE Systems Engineer
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Senior MBSE Systems Engineer needed in Huntsville, AL to support the Missile Defense Agency. You will architect and implement Model-Based Systems Engineering (MBSE) solutions using Cameo, focusing on the Government Reference Architecture. Requires a STEM degree, 12+ years with an MS (or 20+ with ...
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United States , Huntsville
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Not provided
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Astrion
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Senior Systems Verification Engineer
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Senior Systems Verification Engineer sought by Baxter in Round Lake, IL to drive life-saving medical device testing. Leverage 3+ years of experience in ISO/FDA standards to lead IQ/OQ/PQ, system validation, and traceability. Collaborate on infusion system verification with a team dedicated to sav...
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Location
United States , Round Lake
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Salary
96000.00 - 132000.00 USD / Year
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Baxter
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Senior Systems Engineer
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Senior Systems Engineer sought to lead Delinea Tools Suite deployment across Linux environments in Annapolis Junction, MD. This role requires strong Linux systems engineering (RHEL, Rocky, CentOS, Ubuntu), Bash/Python scripting, and hands-on experience with Delinea products like Secret Server or ...
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United States , Annapolis Junction
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Not provided
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2HB
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Senior Systems Engineer
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Senior Systems Engineer needed for a critical 7-year IC contract in Chantilly, VA. You will provide SETA & SE&I services for space domain missions, working directly with government customers and users. Requires a TS/SCI with Poly, a technical BS, and 1-3 years of RF communications experience. Enj...
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United States , Chantilly
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Salary
94940.76 - 165031.40 USD / Year
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Arcfield
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Technology Engineer – Senior (1043) - Systems Specialty - Citywide
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Senior Technology Engineer sought for Citywide Systems Specialty in San Francisco. Lead operational support for complex cloud, on-premises, and hybrid systems. Requires an associate degree in computer science or related field plus one year of system/platform experience. Drive infrastructure-as-co...
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United States , San Francisco
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Salary
156000.00 - 196300.00 USD / Year
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City and County of San Francisco
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Senior IT Platform / Systems Engineer
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Senior IT Platform / Systems Engineer needed for a long-term contract in New York, NY. This hands-on role requires 6+ years of enterprise experience managing Okta, Active Directory, and Azure AD. You will drive infrastructure as code (Terraform, Ansible) and support multi-cloud environments. Enjo...
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United States , New York
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Not provided
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Robert Half
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Senior Systems Integration Engineer
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Senior Systems Integration Engineer needed in Annapolis Junction, MD to support a government customer. You will develop, test, and sustain automation tools for HPC infrastructure in a Linux environment. Requires 10+ years of COTS/GOTS integration experience, Linux CLI expertise, and Bash/Python s...
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United States , Annapolis Junction
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Not provided
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2HB
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Senior Systems Integration Engineer
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Senior Systems Integration Engineer needed in Annapolis Junction, MD to support a government customer. You will administer and maintain the Platform-as-a-Service (PaaS) for secure, high-performance Kubernetes clusters. Requires 8+ years integrating COTS/GOTS software, Linux CLI, and Bash/Python s...
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United States , Annapolis Junction
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Not provided
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2HB
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Senior Robotic Systems Integration Engineer (SLA & SLS)
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Senior Robotic Systems Integration Engineer (SLA & SLS) sought in Boston. You will own system-level integration, bridging firmware and hardware to deliver physical prototypes. Requires 3+ years in electro-mechanical design, motion control, and Python scripting. Enjoy RSUs, comprehensive healthcar...
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United States , Boston
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Salary
130000.00 - 163000.00 USD / Year
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Formlabs GmbH
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Senior SIGINT Systems Engineer
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Senior SIGINT Systems Engineer sought to lead SIGINT programs into Agile, Cloud, and AI/ML-driven futures. This role pioneers model-driven systems engineering, requiring a Top Secret/SCI clearance with Polygraph and 10+ years of aerospace systems experience. Based in Chantilly, VA, you will coord...
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United States , Chantilly
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Salary
135035.83 - 218941.46 USD / Year
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Arcfield
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Senior Network Engineer - Millennium Space Systems
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Senior Network Engineer sought by Millennium Space Systems, a Boeing company in El Segundo, CA, to design secure, scalable network architectures for national security space missions. Requires 6+ years’ experience, expertise in multi-vendor routing/switching (Juniper, Cisco), Palo Alto firewalls, ...
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United States , El Segundo; Los Angeles
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Salary
158950.00 - 215050.00 USD / Year
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Boeing
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Senior Manufacturing Systems Engineer - PLC Systems
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Senior Manufacturing Systems Engineer (PLC Systems) sought by Amgen in Holly Springs, NC. Drive automation solutions for GMP biopharmaceutical production, integrating Rockwell platforms and OEM software. Leverage 4+ years of engineering experience to support capital projects, commissioning, and p...
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United States , Holly Springs
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Salary
136906.95 - 185227.05 USD / Year
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Amgen
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Senior Robotic Systems Integration Engineer
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Senior Robotic Systems Integration Engineer sought by Formlabs to lead the development of groundbreaking 3D printers in Somerville, MA. You will own system-level integration, define control algorithms, and manage complex electro-mechanical requirements. Ideal candidates have 3+ years of experienc...
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United States , Somerville
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Salary
130000.00 - 163000.00 USD / Year
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Formlabs GmbH
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Senior Robotic Systems Integration Engineer (SLA & SLS)
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Senior Robotic Systems Integration Engineer (SLA & SLS) sought in Boston to lead complex electro-mechanical system design and prototyping. You will bridge firmware and hardware, define control algorithms, and manage subsystem requirements. Ideal candidates have 3+ years of experience with motion ...
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United States , Boston
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Salary
130000.00 - 163000.00 USD / Year
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Formlabs GmbH
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Systems Engineer Senior Level
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Senior-Level Systems Engineer needed in Annapolis Junction for a TS/SCI polygraph-cleared role supporting U.S. Government missions. You will lead system requirements analysis, architecture design, and integration efforts. Requires 20+ years of SE experience, a relevant Bachelor’s degree, and Cros...
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United States , Annapolis Junction
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Salary
210000.00 - 237500.00 USD / Year
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Integrity Technology Consultants
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Senior Systems Engineer
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Senior Systems Engineer needed in Warrenton, VA to support mission-critical programs. Requires a Top Secret clearance and 10+ years of experience in system integration, automation (Bash/Python), and documentation. You will design solutions, perform V&V tasks, and work with Java, Elastic, and Dock...
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Location
United States , Warrenton
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Salary
150000.00 - 200000.00 USD / Year
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Altamira Technologies
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About the Senior Systems Engineer role

Explore Senior Systems Engineer Jobs and discover a pivotal career at the intersection of deep technical expertise and strategic project leadership. Senior Systems Engineers are the architectural backbone of complex technological initiatives, responsible for designing, integrating, and maintaining sophisticated systems that form the core infrastructure of modern organizations. This role transcends singular disciplines, requiring a holistic approach to ensure that all system components—whether hardware, software, or network—work seamlessly together to meet business and performance objectives.

Professionals in these senior roles typically bear the responsibility for the entire systems lifecycle. They analyze requirements, architect robust solutions, and oversee implementation and deployment. A core duty involves troubleshooting high-level issues, performing root cause analysis, and ensuring system reliability, security, and scalability. They act as critical liaisons, translating business needs into technical specifications and guiding cross-functional teams of developers, network administrators, and other engineers. Furthermore, Senior Systems Engineers are often tasked with establishing best practices, creating documentation, mentoring junior staff, and driving continuous improvement through automation and process refinement.

The skill set for these jobs is both broad and deep. A strong foundation in systems theory is essential, coupled with expertise in specific domains such as cloud platforms (AWS, Azure, GCP), virtualization, scripting and automation (Python, Bash, PowerShell), and infrastructure as code (Terraform, Ansible). Proficiency in monitoring and observability tools is crucial for maintaining system health. Beyond technical prowess, successful candidates demonstrate exceptional problem-solving abilities, project management skills, and clear communication to interact effectively with both technical teams and stakeholders. Typically, employers seek candidates with a bachelor’s degree in computer science, engineering, or a related field, supplemented by several years of hands-on systems engineering experience, with a proven track record in designing and managing complex, scalable environments.

Senior Systems Engineer jobs represent a career path for seasoned technical professionals ready to take on architectural ownership and strategic influence. These positions are found across every industry, from finance and healthcare to technology and manufacturing, offering the opportunity to build and sustain the critical systems that power innovation and operational excellence. If you are a systems thinker with a passion for integration, optimization, and leadership, exploring Senior Systems Engineer roles could be your next career milestone.