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Senior System Engineer Jobs (Remote work)

48 Job Offers

Senior Cloud Systems Engineer
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Canada , Halifax
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100000.00 - 125000.00 CAD / Year
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NTT DATA
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Senior Build System Engineer
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Open Home Foundation
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Senior Build System Engineer
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Open Home Foundation
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Senior Systems Engineer
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Multiple
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Deel
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Senior AI Engineer (Natural Language Systems)
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160000.00 - 220000.00 USD / Year
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Prompt
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Senior Software Engineer, Backend Systems
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United States
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184600.00 - 260700.00 USD / Year
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Docker
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Senior ML Systems Engineer, Frameworks & Tooling
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Cohere
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Senior Presales Systems Engineer
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Join HPE Networking as a Senior Presales Systems Engineer in Baltimore. Leverage your 4+ years of networking expertise in routing, switching, wireless, and security to design cutting-edge solutions. You will create technological roadmaps, lead Proof-of-Concepts, and position HPE's AI-driven portf...
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United States , Baltimore
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146000.00 - 343000.00 USD / Year
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Hewlett Packard Enterprise
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Senior AI System Engineer
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Join Spring Health as a Senior AI System Engineer. Design and build internal AI solutions and automation frameworks using Python and LLM-based applications. Partner across the organization to enable safe AI adoption and integrate systems via APIs. Enjoy comprehensive benefits from day one, includ...
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159100.00 - 194150.00 USD / Year
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Spring Health
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Senior Software Engineer, Marketing Systems
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Seize this opportunity to shape the future of healthcare marketing technology. As a Senior Software Engineer for Marketing Systems, you will architect solutions on Salesforce Marketing Cloud (SFMC) and CMS platforms like Webflow. Your expertise in AMPscript, SQL, and data integrations will drive ...
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United States , Manchester, NH / Marlborough, MA
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150000.00 - 165000.00 USD / Year
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Sequel Med Tech
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Senior Systems Engineer- Contact Center
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United States , Marlborough
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Sequel Med Tech
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Senior DevOps / Systems Engineer
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Mexico
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Tech Holding
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Senior Staff Software Engineer - Distributed Systems
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Join Fivetran as a Senior Staff Software Engineer in Germany, focusing on our Managed Data Lake. You will design and operate scalable, high-performance distributed systems using Java and Kubernetes on public clouds. This role offers competitive benefits, including full medical coverage and RSUs, ...
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Germany
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Fivetran
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Senior Distributed Systems Engineer - Bidding Platform
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Poland
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RTB House
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Senior Context Engineer, AI Systems
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Join MagicSchool as a Senior Context Engineer for AI Systems. Architect and optimize AI agents within educational workflows, focusing on context management, state, and knowledge retrieval. Requires 4+ years in distributed systems, RAG, Python/TypeScript, and LLM APIs. Enjoy unlimited PTO, health ...
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United States
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160000.00 - 190000.00 USD / Year
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EdTech Jobs
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Senior Machine Learning System Engineer
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Join Atlassian's AI & ML Platform team as a Senior ML System Engineer. You will build core infrastructure for ML model lifecycle management, using Java/Kotlin, Python, and AWS. This remote US role offers a chance to impact millions of users while enjoying health benefits and paid volunteer time.
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United States , Seattle; San Francisco; New York; Austin
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165500.00 - 265800.00 USD / Year
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Atlassian
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Senior Principal Machine Learning Systems Engineer
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Lead the development of foundational AI infrastructure at Atlassian as a Senior Principal ML Engineer. You will design systems, train complex models, and integrate AI capabilities across products. Requires 10+ years of ML experience, expertise in Python/Java, and cloud data platforms. Based in Se...
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United States , Seattle; San Francisco; Austin
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243100.00 - 407200.00 USD / Year
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Atlassian
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Senior Machine Learning Systems Engineer
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Join Atlassian in Bengaluru as a Senior Machine Learning Systems Engineer. Build core infrastructure to democratize ML/AI for products like Jira. Leverage your expertise in Java/Kotlin, AWS, and LLMs to develop scalable, high-performance systems. Enjoy health coverage, paid volunteer days, and we...
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India , Bengaluru
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Atlassian
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Senior Pre-Sales System Engineer - Aruba
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Join HPE Aruba Networking as a Senior Pre-Sales System Engineer in Los Angeles. Leverage your 5+ years of networking expertise in routing, switching, and WiFi to design customer technology roadmaps. Provide technical leadership and support strategic sales with your knowledge of Aruba, Cisco, or J...
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United States , Los Angeles
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141000.00 - 332000.00 USD / Year
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Hewlett Packard Enterprise
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Senior Platform Engineer, ML Data Systems
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Join Khan Academy as a Senior Platform Engineer for ML Data Systems. Design and deploy scalable dataset management frameworks using Go, Python, and Airflow on GCP. Ensure clean, representative data for AI tutoring by collaborating with engineering and labeling teams. This remote-first role offers...
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United States , Mountain View
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137871.00 - 172339.00 USD / Year
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Khan Academy
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About the Senior System Engineer role

Discover and apply for Senior System Engineer jobs, a critical and high-impact career path at the intersection of technology, strategy, and complex problem-solving. Senior System Engineers are the master architects and technical leaders responsible for designing, integrating, and maintaining the sophisticated systems that power modern enterprises and critical infrastructure. This role transcends basic IT support, focusing on the holistic lifecycle of large-scale systems, from initial concept and requirements analysis through to deployment, integration, and ongoing optimization.

Professionals in these senior-level jobs act as the crucial bridge between business objectives, user needs, and technical execution. A typical day involves analyzing high-level requirements and translating them into detailed system specifications and architectural blueprints. They guide cross-functional engineering teams, ensuring that various components—hardware, software, network, and cloud services—work seamlessly together as a cohesive system. A core responsibility is leading systems integration efforts, developing comprehensive test plans, and managing the technical integrity of major projects. Furthermore, Senior System Engineers are often tasked with evaluating new technologies, conducting feasibility studies and trade-off analyses, and developing strategic roadmaps to evolve system capabilities while ensuring reliability, security, and scalability.

The skill set required for Senior System Engineer jobs is both broad and deep. A strong foundation in systems engineering principles and methodologies is paramount. Candidates typically possess extensive experience with the full systems development lifecycle (SDLC) and are proficient in creating essential documentation such as System Engineering Plans (SEP) and architecture diagrams. Technical expertise often includes knowledge of cloud platforms, cybersecurity principles, and scripting or programming languages like Python for automation and tooling. Beyond technical acumen, these roles demand exceptional analytical and problem-solving skills to deconstruct complex challenges. Leadership and communication are equally critical, as Senior System Engineers must mentor junior staff, collaborate with stakeholders across departments, and clearly articulate technical concepts to non-technical executives and government overseers.

Typical requirements for these positions include a bachelor’s or master’s degree in systems engineering, computer science, information technology, or a related STEM field. Most roles require a substantial professional background, often 10+ years of progressive experience in systems engineering, with a proven track record of leading projects of significant scope and complexity. While specific security clearances are context-dependent for government roles, a general emphasis on systems that handle sensitive data is common. For those seeking a career where they can shape technological strategy and ensure the robustness of mission-critical operations, exploring Senior System Engineer jobs offers a challenging and rewarding pathway.