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Senior System Engineer Jobs (On-site work)

168 Job Offers

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Senior Manufacturing Systems Engineer
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Join Amgen's state-of-the-art FleX Batch manufacturing facility in Holly Springs. Lead automation engineering for GMP drug substance production, utilizing Siemens Desigo CC and PLC systems. This role requires a relevant engineering degree and extensive experience in BAS design and biopharmaceutic...
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United States , Holly Springs
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147421.00 - 177467.00 USD / Year
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Amgen
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Until further notice
Senior-Staff Software Engineer, Business Systems
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Seeking a Senior-Staff Software Engineer for Business Systems in San Mateo. Design and implement scalable solutions across AWS, Salesforce, and NetSuite, focusing on data reliability and process automation. Requires 8+ years of distributed systems expertise and AWS cloud services. Enjoy comprehen...
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United States , San Mateo
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180000.00 - 280000.00 USD / Year
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Verkada
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Senior Systems Engineer - Safety Focus
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Join Boston Dynamics as a Senior Systems Engineer focused on Safety in Waltham, USA. You will lead safety design and compliance for autonomous mobile robots, applying expertise in functional safety standards like ISO 13849. This role requires 5+ years in complex mechatronic systems and offers med...
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United States , Waltham
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154310.00 - 212176.00 USD / Year
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Boston Dynamics
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Senior Systems Engineering Manager
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Lead mechanical and electrical equipment specification for cutting-edge data center projects in San Francisco. This senior management role requires deep MEP expertise, vendor bid leveling, and multi-project oversight. Enjoy top benefits like stock units, comprehensive health plans, and a strong 4...
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United States , San Francisco
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190000.00 - 220000.00 USD / Year
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Crusoe
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Senior Systems Engineer I
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Join ICON's Titan Team in Austin as a Senior Systems Engineer I. You will lead hands-on development and technical design for advanced industrial print systems, moving prototypes to production. This role requires 8+ years of systems engineering experience with industrial robotics and automation. A...
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United States , Austin
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Not provided
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ICON
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Senior AI Engineer – Agentic Systems
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Join a pioneering team in Dubai as a Senior AI Engineer, building autonomous agentic systems for enterprise workflows. You will design and deploy production-grade AI agents using LLMs, RAG, and orchestration tools like LangGraph. This foundational role offers top-tier compensation, equity, and a ...
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United Arab Emirates , Dubai
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Not provided
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Salt
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Senior Systems Engineer
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Join a pioneering team as a Senior Systems Engineer, shaping the future of revolutionary seaglider vehicles. You will develop certification-focused systems engineering artifacts and drive verification in a safety-critical, regulated environment. This role in North Kingstown offers competitive com...
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United States , North Kingstown
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Not provided
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REGENT Craft
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Senior Engineer, Mechanical Mission Systems
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Seeking a Senior Mechanical Engineer in North Vancouver to lead marine mission systems design. This role requires a P.Eng. with 10+ years in mechanical systems, focusing on launch/recovery, winches, and hydraulics. You will oversee projects from concept to close-out, ensuring compliance with all ...
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Canada , North Vancouver
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119700.00 - 146300.00 CAD / Year
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Washington Corporations
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Until further notice

About the Senior System Engineer role

Discover and apply for Senior System Engineer jobs, a critical and high-impact career path at the intersection of technology, strategy, and complex problem-solving. Senior System Engineers are the master architects and technical leaders responsible for designing, integrating, and maintaining the sophisticated systems that power modern enterprises and critical infrastructure. This role transcends basic IT support, focusing on the holistic lifecycle of large-scale systems, from initial concept and requirements analysis through to deployment, integration, and ongoing optimization.

Professionals in these senior-level jobs act as the crucial bridge between business objectives, user needs, and technical execution. A typical day involves analyzing high-level requirements and translating them into detailed system specifications and architectural blueprints. They guide cross-functional engineering teams, ensuring that various components—hardware, software, network, and cloud services—work seamlessly together as a cohesive system. A core responsibility is leading systems integration efforts, developing comprehensive test plans, and managing the technical integrity of major projects. Furthermore, Senior System Engineers are often tasked with evaluating new technologies, conducting feasibility studies and trade-off analyses, and developing strategic roadmaps to evolve system capabilities while ensuring reliability, security, and scalability.

The skill set required for Senior System Engineer jobs is both broad and deep. A strong foundation in systems engineering principles and methodologies is paramount. Candidates typically possess extensive experience with the full systems development lifecycle (SDLC) and are proficient in creating essential documentation such as System Engineering Plans (SEP) and architecture diagrams. Technical expertise often includes knowledge of cloud platforms, cybersecurity principles, and scripting or programming languages like Python for automation and tooling. Beyond technical acumen, these roles demand exceptional analytical and problem-solving skills to deconstruct complex challenges. Leadership and communication are equally critical, as Senior System Engineers must mentor junior staff, collaborate with stakeholders across departments, and clearly articulate technical concepts to non-technical executives and government overseers.

Typical requirements for these positions include a bachelor’s or master’s degree in systems engineering, computer science, information technology, or a related STEM field. Most roles require a substantial professional background, often 10+ years of progressive experience in systems engineering, with a proven track record of leading projects of significant scope and complexity. While specific security clearances are context-dependent for government roles, a general emphasis on systems that handle sensitive data is common. For those seeking a career where they can shape technological strategy and ensure the robustness of mission-critical operations, exploring Senior System Engineer jobs offers a challenging and rewarding pathway.

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