Principal Systems Engineer Jobs

Lead systems architecture for innovative active implantable medical devices as a Principal R&D Engineer in Minneapolis. Drive system design, requirements hierarchy, and risk management (FMEA, ISO 14971) with 7+ years of experience. Foster innovation and quality compliance while enjoying comprehen...

Seeking a Sr Principal Software Systems Engineer & Product Owner to lead groundbreaking digital health solutions in Raleigh. Drive product strategy for connected Infusion Pump Platforms and cloud-based applications (SaaS/PaaS). Leverage your Product Owner expertise and customer insights to manage...

Principal Embedded Systems Engineer sought by Baxter in Raleigh to lead R&D of life-saving medical technologies. Requires 5+ years’ C/C++ embedded development, expertise in microcontrollers, Linux, and hardware debugging. Drive full SDLC, make critical build trade-offs, and collaborate cross-func...

Principal Software Engineer role on Microsoft’s CoreAI FIT Agentic Systems team, building the AI infrastructure for Azure. You will develop scalable infrastructure for training LLMs, SLMs, and agentic models, designing API orchestration layers with OpenAI. Requires 6+ years in C, C++, Python, and...

Lead systems engineering for a closed-loop epilepsy therapy system as a Principal Systems Engineer in Plymouth, MN. Drive neural interface performance, seizure detection algorithms, and end-to-end data flow for an active implantable medical device (AIMD) within a PMA framework. Requires 10+ years...

Lead complex FORNSAT and RF-enabled systems as a Principal Systems Engineer at Columbia Technology Partners in Annapolis Junction. This role demands 20+ years of systems engineering experience, an active security clearance, and DOD 8570 certification. You will architect GOTS-based solutions, mana...

Principal Systems Engineer sought for Baxter’s R&D team in Palm Beach Gardens, FL. Drive innovative medical device development by translating customer needs into system requirements and leading architecture design. Requires a Bachelor’s in Engineering, 5+ years of cross-functional experience, and...

Seeking a Principal Systems Engineer to support a government customer in Annapolis Junction, MD. This role requires 18-20+ years of systems engineering experience with a Bachelor’s degree or higher, plus expertise in Linux, Kubernetes, Docker/podman, and security scanning. You will lead dataflow ...

Columbia Technology Partners seeks a Principal Systems Engineer to lead engineering and sustainment of mission-critical FORNSAT and RF-enabled systems. This senior role requires 20+ years of systems engineering experience, an active security clearance with polygraph, and expertise in Linux, virtu...

Principal Systems Safety Engineer sought in Phoenix, AZ to lead safety strategies for advanced avionics platforms. You will conduct hazard analyses, develop fault trees, and ensure compliance with SAE/ARP 4761 and 4754A. Ideal candidates have 6+ years in commercial avionics and expertise in FHA-F...

Principal Systems Engineer needed for a 12-month contract in Edinburgh or Newcastle. You will support radar system development by analyzing large datasets from rig and flight trials using MATLAB. Key requirements include V-model lifecycle expertise, safety-critical systems experience, and SC Clea...

Lead the mechanical systems design for critical national security flight test programs. This senior role requires an active DOE Q or DoD TS clearance and a background in R&D mechanical engineering. You will guide teams through design, assembly, and testing in a collaborative environment. The posi...

Principal Quantum Systems Digital Design Engineer at Microsoft in Redmond. Design FPGA-based, ultra-low-latency digital subsystems for topological quantum computing, including readout classification and error-decoder acceleration. Requires a Doctorate/Master’s in Physics or EE with 3+ years exper...

Lead innovative renewable energy projects as a Principal Power Systems Engineer in Perth. This role requires extensive experience in power system analysis and grid connection studies for sustainable energy solutions. You will provide technical leadership on cutting-edge projects with a global eng...

Seeking a Senior Principal Product Owner to lead digital application development for Infusion Pump Platforms in Raleigh. You will translate customer and clinical insights into product features, managing backlogs in an Agile environment. This role requires expertise in regulated medical devices, c...

Lead PCIe Gen5/6 system architecture for SanDisk's next-gen NVMe SSDs in Bangalore. Own end-to-end design from PHY/IP integration to firmware guidelines for client and enterprise products. Apply deep expertise in link training, power management, and performance tuning to shape cutting-edge storag...

Join Baxter Healthcare as a Principal Embedded Systems Engineer in Raleigh, NC. Drive firmware development for clinical communication products using C/C++ on microcontrollers. Apply your expertise in embedded protocols and hardware debugging within an Agile SDLC. Enjoy comprehensive benefits incl...

Lead Systems Integration and Assurance for major rail projects across the UK and internationally. Provide technical leadership in engineering assurance, safety (CSM/CDM), and multi-party system integration. Mentor teams and drive consistency on metro, high-speed, and heavy rail designs. This role...

Lead the development of groundbreaking healthcare solutions as a Principal Software Systems Engineer in Raleigh. You will drive new product development for Infusion Pump Platforms using Agile methodologies and Systems Engineering. This role requires expertise in regulated medical devices, require...

Lead architecture and solution design for global AI/ML, Data Center, and WAN networking opportunities at HPE. This hybrid role requires 15+ years of deep expertise in hyperscale network infrastructure, SDN overlays, and automation. Act as a key technical architect, translating complex business ne...