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Principal Scientist Jobs

155 Job Offers

Principal Scientist – Synthetic Separations
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Lead analytical strategy for drug discovery at Amgen's Genome Valley facility in Hyderabad. Utilize deep expertise in LC/MS, SFC, and NMR to characterize novel compounds. This senior role requires a PhD with 8+ years' industry experience and leadership in synthetic separations.
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India , Hyderabad
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Not provided
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Amgen
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Senior Principal Data Scientist
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Lead strategic data initiatives as a Senior Principal Data Scientist at Atlassian. Leverage 10+ years of expertise in SQL, Python, and statistics to influence AI product strategy and drive business impact. Mentor a team while enjoying top benefits like health coverage, equity, and wellness resour...
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United States
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193500.00 - 303150.00 USD / Year
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Atlassian
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Principal Applied Scientist
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Lead the scientific vision for real-time ad bidding at Zalando in Berlin. Apply your expertise in auction theory, ML optimization, and low-latency systems to solve high-stakes challenges. This principal role requires 7+ years in Ad Tech and offers a hybrid model, relocation support, and impactful...
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Germany , Berlin
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Not provided
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Zalando Sverige
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Senior / Principal Data Scientist
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Lead AI/ML strategy and high-impact modeling to improve patient outcomes in a modern healthcare data environment. This Dallas-based role requires a PhD and 8+ years' expertise in Python/R, Spark, Databricks, and Azure, with deep healthcare data knowledge. You will deploy predictive models from Ep...
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United States , Dallas
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Not provided
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Tier4 Group
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Principal Data & Analytics Scientist
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Join Microsoft's Monetization Marketplace Team as a Principal Data & Analytics Scientist. Leverage your 5+ years of experience in Python/R and experimental design to drive insights for the global Advertising platform. You will define metrics, build analytical frameworks, and influence data-driven...
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United States , Redmond; Mountain View; New York; Atlanta
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Lead advanced machine learning initiatives for Microsoft's global computational advertising team in Bangalore. Design and optimize large-scale systems for ad matching, ranking, and multi-objective optimization. Requires 10+ years of ML experience, expertise in statistics, A/B testing, and distrib...
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India , Bangalore
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Not provided
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Microsoft Corporation
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Principal Applied Scientist - Small Language Models
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Lead groundbreaking research in Small Language Models (SLMs) and multimodal AI at Microsoft's Applied Sciences Group in Reading, UK. As a Principal Applied Scientist, you will design unified token-based architectures and scalable training pipelines for next-generation user experiences. This senio...
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United Kingdom , Reading
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Not provided
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Microsoft Corporation
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Principal AI and Machine Learning Scientist
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Lead groundbreaking AI initiatives as a Principal Scientist in Malvern or Charlotte. Design and validate LLMs and intelligent agents for trustworthy financial advice and hyper-personalized portfolios. Mentor junior talent while enjoying top-tier benefits, from competitive compensation to leading ...
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United States , Malvern; Charlotte
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Vanguard
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Principal Scientist
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Join our team in Norcross, GA as a Principal Scientist. Bridge clinical transfusion medicine with product innovation to enhance diagnostic solutions and patient safety. Utilize your SBB certification and 5+ years of experience in serology, molecular typing, and IVD development. Drive product desi...
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United States , Norcross, Georgia
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werfen
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Principal Applied Scientist - ZMS
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Lead the scientific vision for real-time bidding at Zalando in Berlin. Drive optimization at the intersection of auction theory, ML, and high-load engineering. Requires 7+ years in Ad Tech, expert ML production skills, and a strong research track record. Enjoy a hybrid model, relocation support, ...
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Germany , Berlin
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Zalando Sverige
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Principal Applied Scientist - ZMS
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Lead the scientific vision for real-time ad auctions at Zalando Marketing Services in Berlin. Drive optimization at the intersection of auction theory, ML, and high-load systems. Requires 7+ years of applied research excellence in ad tech and expertise in low-latency ML. Enjoy a hybrid model, rel...
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Germany , Berlin
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Zalando Lounge
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Principal Applied Scientist
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Lead AI innovation at Viva Engage as a Principal Applied Scientist. Design and deploy cutting-edge machine learning and LLM-driven features to enhance discovery and engagement. Utilize large datasets to build predictive models and agentic applications within the Office 365 ecosystem. This role is...
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United States , Mountain View
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Join Microsoft AI in Mountain View as a Principal Applied Scientist. You will build production ML models and work hands-on with SOTA generative models like Qwen, Llama, and GPT. This role requires expertise in Generative AI, LLMs, and large-scale data, aiming to advance Bing and Consumer Copilot....
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United States , Mountain View
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Applied Scientist
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Join Microsoft Security as a Principal Applied Scientist in Redmond. Develop and deploy production AI models to detect social engineering attacks and protect customers. Requires a relevant advanced degree and 4+ years of experience in predictive analytics and live systems. Embrace a growth mindse...
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United States , Redmond
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139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Senior Principal Scientist In Vivo Pharmacology
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Lead groundbreaking in vivo pharmacology research in metabolic disorders at our Nottingham site. This senior role requires deep expertise in obesity, diabetes, and cardiometabolic drug discovery. You will design studies, lead projects, and mentor teams in a fully onsite, collaborative environment...
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United Kingdom , Nottingham
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Not provided
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Proclinical
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About the Principal Scientist role

A Principal Scientist is a senior-level research and development leader who drives innovation by designing, building, and deploying advanced machine learning and artificial intelligence systems at scale. These professionals typically operate at the intersection of theoretical research and practical engineering, translating complex scientific concepts into production-ready solutions that power core business products and user experiences. Principal Scientist jobs are distinguished by their emphasis on strategic technical leadership, cross-functional collaboration, and high-impact problem solving.

The core responsibilities of a Principal Scientist often include architecting large-scale ML and deep learning pipelines, developing novel model architectures for ranking, recommendation, personalization, and generative AI systems. They are responsible for defining evaluation frameworks, designing experiments, and establishing metrics that accurately measure both system performance and user value. A significant portion of the role involves mentoring junior scientists and engineers, setting technical standards, and driving alignment across product, engineering, and data science teams. Principal Scientists also lead the integration of cutting-edge techniques such as large language models (LLMs), retrieval-augmented generation, agentic systems, and multi-objective optimization into existing infrastructure. They regularly communicate complex technical strategies to diverse stakeholders and act as trusted advisors on data-driven decision making.

Typical skills and requirements for Principal Scientist positions include an advanced degree (PhD or Master’s) in computer science, statistics, mathematics, operations research, or a related quantitative field, combined with extensive experience—often six to ten years or more—delivering production ML systems. Deep expertise in recommendation systems, search relevance, natural language processing, or generative AI is common. Proficiency in modern ML frameworks (e.g., PyTorch, TensorFlow), large-scale data processing (e.g., Spark), and cloud infrastructure is essential. Strong architectural skills for designing distributed, high-throughput services are critical, as is a solid publication record in top-tier conferences (e.g., NeurIPS, KDD, ICML, RecSys). Beyond technical depth, these roles demand exceptional communication, mentorship, and strategic influence abilities. Principal Scientist jobs are ideal for individuals who thrive on solving ambiguous, high-stakes challenges and driving measurable impact through scientific innovation and technical leadership.