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Principal United States Jobs

1654 Job Offers

Process Development Principal Scientist
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Lead analytical development for late-phase clinical programs at Amgen in Cambridge, MA. As a Process Development Principal Scientist, you will define control strategies, drive method optimization, and support cGMP manufacturing. Requires a PhD with 3+ years industry experience in small molecule a...
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141836.95 - 191897.05 USD / Year
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Amgen
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Principal GTM Strategist
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Appian seeks a Principal GTM Strategist to shape its AI automation market narrative in McLean, VA. This senior role requires 10-15+ years in B2B narrative strategy and C-suite partnership. You will translate complex AI capabilities into executive business value, own messaging AI notebooks, and dr...
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150000.00 - 300000.00 USD / Year
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Appian Corporation
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Principal Data Scientist
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Principal Data Scientist role at Microsoft AI in Redmond, driving analytics for MSN & Copilot Discover. Leverage AI and machine learning to build forecasting models, analyze user engagement and monetization, and shape product strategy. Requires a Doctorate or Master’s in Data Science or related f...
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Associate, Contract Manager
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Join Capital One as a Principal Associate, Contract Manager in McLean, Chicago, Richmond, Plano, New York, or Riverwoods. Leverage your 2+ years of contract drafting, negotiation, and legal experience to drive deal strategies and manage supplier transactions. Collaborate within a inclusive ESM te...
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United States, McLean, Chicago, Richmond, Plano, New York, Riverwoods
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Not provided
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Capital One
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Principal Software Engineering Manager
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Software Engineer – Test Automation
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Principal Software Engineer – Test Automation role at Baxter in Bellevue, WA. Drive life-saving medical product quality by designing scalable test automation frameworks using Python, Java, or C/C++. Requires 7+ years SDET experience, expertise in PyTest, Selenium, or Robot Framework, and API test...
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112000.00 - 154000.00 USD / Year
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Baxter
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Principal Product Manager
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Seeking a **Principal Product Manager** to lead multi-vertical platform strategy in the **United States**. This senior role unifies Physical Therapy, Diagnostics, and Home Health portfolios, driving scalable automation and market expansion. Requires 10+ years of SaaS product management experience...
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142121.00 - 227394.00 USD / Year
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One Call
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Principal Product Manager
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Principal Product Manager role driving multi-vertical platform strategy for One Call, unifying Physical Therapy, Diagnostics, and Home Health. Requires 10+ years in SaaS product management, leading cross-functional teams in Agile environments. Remote-first position in the US with generous PTO, co...
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142121.00 - 227394.00 USD / Year
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One Call
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Principal Product Manager
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142121.00 - 227394.00 USD / Year
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One Call
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Principal Product Manager, Data and AI Products
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Lead the future of data and AI at Blackbaud as Principal Product Manager. Drive scalable data mesh and AI/ML platform strategy, owning end-to-end product delivery for mission-critical systems. Requires 8+ years in product management with deep data product expertise. Enjoy remote flexibility, comp...
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Salary
117200.00 - 157500.00 USD / Year
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Blackbaud
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Principal Engineers, Systems Design
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Principal Engineers, Systems Design in Herndon, VA drive 5G innovation at T-Mobile. You will lead complex network design projects, optimize RAN configurations, and validate advanced 5G features. Requires a Master’s degree in Computer Science or related field with 3 years of experience. Enjoy a co...
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161782.00 - 202900.00 USD / Year
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T-Mobile
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Principal Quantum Systems Architect
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Join Microsoft Quantum in Redmond as a Principal Quantum Systems Architect to define scalable control and readout architectures. Drive system-level trade-offs across cryogenic and room-temperature domains for revolutionary quantum computing. Requires a PhD or equivalent experience in Physics/Engi...
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165600.00 - 296400.00 USD / Year
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Microsoft Corporation
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Senior Principal Controls Engineer
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Senior Principal Controls Engineer sought by Baxter in Round Lake, IL to lead automation and digital transformation in a life-saving manufacturing environment. This onsite role requires 8+ years of experience with Allen-Bradley PLCs, robotics, and vision systems, plus a Bachelor's in Engineering....
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128000.00 - 176000.00 USD / Year
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Baxter
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Principal Software Engineer - Architect
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165600.00 - 296400.00 USD / Year
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Microsoft Corporation
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Principal Technical Program Manager
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Lead a high-impact team as a Principal Technical Program Manager at Microsoft Azure Core. Drive the strategy and execution of Azure's fleet lifecycle and cloud expansion, including AI Regions and New Clouds. Partner with Engineering and Operations to deliver scalable, secure platform capabilities...
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Location
United States, Multiple Locations
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Salary
165600.00 - 331200.00 USD / Year
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Microsoft Corporation
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Principal Product Manager
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Principal Product Manager role in Redmond, WA, driving AI-powered experiences across SharePoint, Microsoft Lists, and M365. Define product vision, partner with enterprise customers, and lead cross-team collaboration to integrate content, automation, and workflows. Requires 8+ years in product man...
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Product Manager, Agent 365 Security & Governance
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Principal Product Manager, Agent 365 Security & Governance – Redmond, WA. Lead the security strategy for Microsoft’s AI agent governance product. Define the category narrative, drive cross-org alignment across security & identity, and translate telemetry into actionable risk intelligence. Ideal f...
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Product Manager, M365 Core
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Principal Product Manager for M365 Core Platform in Redmond, WA. Drive the evolution of hyperscale storage and fleet infrastructure to support AI and Copilot growth. Define multi-year strategy, own KPIs and SLAs, and integrate AI-informed analysis into prioritization. Requires 8+ years in product...
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Product Manager
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Lead the team ensuring Microsoft Edge’s core health, performance, and reliability for hundreds of millions of users. As Principal Product Manager Manager in Redmond, you will set strategy, coach PMs, and drive quality, efficiency, and feature-health initiatives. Requires 8+ years in product manag...
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Salary
142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Senior Principal Controls Engineer
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Senior Principal Controls Engineer sought in Round Lake, IL to drive automation and reliability in life-saving medical device manufacturing. Leverage expertise in Allen-Bradley PLCs, robotics, and vision systems to optimize equipment and lead digital transformation. Requires 8+ years in manufactu...
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Salary
128000.00 - 176000.00 USD / Year
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Baxter
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About the Principal role

A Principal role represents a senior leadership position found across various industries, from construction and engineering to technology and product management. Individuals in these jobs are trusted with high-level strategic oversight, complex problem-solving, and driving significant organizational impact. Unlike entry-level or mid-career positions, Principal jobs typically require a deep well of specialized expertise, a proven track record of leadership, and the ability to influence direction without direct managerial authority over every team member.

In a professional context, a Principal is often the highest individual contributor or a senior team lead responsible for shaping the vision and execution of critical initiatives. For example, in design and construction sectors, a Principal Designer focuses on risk management from the earliest stages of a project. They ensure that health and safety regulations, such as the CDM Regulations 2015, are integrated into the design process, mitigating hazards before construction begins. This involves leading cross-functional coordination, conducting design reviews, and ensuring a seamless handover to contractors.

In technology and business strategy, Principal Product Managers own the end-to-end lifecycle of complex service portfolios or product lines. They are responsible for defining strategy, developing business cases, and launching innovative offerings that drive customer adoption and revenue growth. These roles demand a data-driven approach to decision-making, strong cross-functional leadership, and the ability to influence executives and stakeholders across engineering, sales, marketing, and customer success teams. Common responsibilities include market analysis, competitive benchmarking, pricing strategy, and building go-to-market plans.

Typical skills required for Principal jobs include exceptional communication and presentation abilities, strategic thinking, and a high degree of autonomy. Candidates usually possess a bachelor’s or master’s degree in a relevant field, combined with significant experience—often eight or more years in a related domain. Technical proficiency is critical, whether in understanding network security, cloud infrastructure, or construction regulations. Soft skills such as negotiation, mentorship, and the ability to drive alignment in matrixed organizations are equally important.

Ultimately, Principal jobs are about leading from the front, solving the most challenging problems, and setting the standard for excellence within an organization. Whether mitigating risk on a construction site or defining the future of a software platform, these professionals are integral to driving meaningful, lasting results.