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Principal United States Jobs (Remote work)

333 Job Offers

Principal UX/UI Designer
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Principal UX/UI Designer sought in Philadelphia to lead end-to-end design for consumer-facing digital tools. Requires 7+ years of experience, a strong portfolio, and expertise in Figma and design systems. Drive intuitive, high-end user experiences, evolve design patterns, and collaborate with cro...
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75.00 - 82.00 USD / Hour
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Beacon Hill
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Principal Product Manager
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Principal Product Manager role at Microsoft Security in Redmond, WA. Lead PKI compliance strategy, manage global public trust requirements, and drive standards advancement for Microsoft’s public CAs. Requires 12+ years in product/program management, expertise in browser root programs, and securit...
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165600.00 - 296400.00 USD / Year
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Microsoft Corporation
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Principal Systems Engineer
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As a Principal Systems Engineer at Baxter in Skaneateles Falls, NY, you will lead system and risk activities for life-saving Connected Monitoring products. This role requires a Bachelor's in Engineering, 5+ years of experience, and expertise in ISO 14971 and IEC 62304. You will translate customer...
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United States, Skaneateles Falls
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Salary
112000.00 - 154000.00 USD / Year
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Baxter
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Senior Principal Software Engineer
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Senior Principal Software Engineer sought to build and scale a next-generation iMBSE platform integrating AI into enterprise workflows. You will design full-stack solutions using React, Python, and Rust, while developing Agentic AI, RAG services, and LLM-driven workflows. This remote role offers ...
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127584.65 - 251035.08 USD / Year
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Arcfield
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Principal Designer, TIDAL
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Principal Designer, TIDAL – Lead product vision and design strategy for the artist-first streaming platform. We seek a systems thinker with 8+ years of experience, fluency in AI, and a passion for music. Drive high-impact, strategic work from multi-year visions to iterative releases in a remote-f...
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251600.00 - 377400.00 USD / Year
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Block
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Principal Software Quality Analyst, Civil Engineering
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Principal Software Quality Analyst needed in Exton, PA to certify civil engineering software like OpenRoads Designer and OpenRail Designer. Requires a U.S. Bachelor’s in Civil Engineering and 5 years of experience. Responsibilities include functional, integration, and performance testing, creatin...
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Not provided
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Bentley Systems
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Principal Software Engineer
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Join Microsoft’s Industry Solutions Engineering team as a Principal Software Engineer. Collaborate directly with customers to build cloud-based solutions using C, C++, C#, Java, JavaScript, or Python. This role offers mentorship, cross-product leadership, and up to 25% travel across multiple U.S....
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United States, Multiple Locations
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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SAP Principal Architect, Transportation Management
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Seeking an SAP Principal Architect, Transportation Management to lead S/4 TM design and implementation across Amgen’s global sites. Requires 8+ years of SAP TM experience with end-to-end S/4 implementations and deep knowledge of TM master data, planning, and freight settlement. Based in the US, t...
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167720.30 - 226915.70 USD / Year
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Amgen
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Principal Medical Science Liaison
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Baxter seeks a Principal Medical Science Liaison (MSL) to lead scientific exchange across the Central U.S. This senior, field-based role requires an MD/DO or PA with surgical experience to engage KOLs in Cardiac, Spine, and General Surgery. You will shape regional medical strategy, support clinic...
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128000.00 - 176000.00 USD / Year
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Baxter
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Principal Medical Science Liaison - Smart Infusion Pumps
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Baxter seeks a Principal Medical Science Liaison for Smart Infusion Pumps in Deerfield, IL. This field-based role requires a Pharmacist or Nurse with 5+ years of hospital experience and smart pump expertise. You will build peer-to-peer relationships with KOLs, deliver scientific presentations, an...
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128000.00 - 176000.00 USD / Year
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Baxter
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Principal Data Scientist, Ads
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Lead the future of Reddit’s ad marketplace as a Principal Data Scientist. Drive strategic innovation in auction design, causal inference, and advertiser ROI using advanced statistics and machine learning. Partner with Product and Engineering to build scalable solutions. This remote US role offers...
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Salary
268000.00 - 365100.00 USD / Year
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Reddit
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Principal Data Scientist - Rentals Shopping
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Principal Data Scientist sought to lead the Rentals Shopping pillar at Zillow, driving data strategy for the rental consumer journey. You will partner with product leadership to shape roadmaps using advanced modeling, causal inference, and experimentation at scale. Requires a PhD/Master’s, 8+ yea...
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Location
United States, Remote-USA
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Salary
178300.00 - 284700.00 USD / Year
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Zillow
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Principal Data Scientist - Rentals Marketplace Ads Team
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Join Zillow’s Rentals Marketplace Ads Team as a Principal Data Scientist. Leverage your Ph.D/Master’s and 8+ years of experience in quantitative analysis, A/B testing, and causal inference to build value-based pricing systems. Master SQL, Python, and Databricks to analyze complex datasets and dri...
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169300.00 - 284700.00 USD / Year
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Zillow
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Principal Machine Learning Engineer, Agentic AI
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We are seeking a Principal Machine Learning Engineer to pioneer Agentic AI solutions in the United States. You will design and deploy multi-agent systems using LangChain/LangGraph, leveraging advanced GenAI models for autonomous, context-aware interactions. Ideal candidates possess 7+ years build...
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Not provided
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Zillow
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Principal Researcher
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Join Microsoft as a Principal Researcher in Redmond, driving AI efficiency across the stack. You will formulate novel algorithmic and system-level approaches for end-to-end AI serving, optimizing latency and throughput. Ideal candidates possess a PhD and 6+ years of research experience, with a fo...
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163000.00 - 296400.00 USD / Year
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Microsoft Corporation
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Principal Customer Experience Engineer
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Principal Customer Experience Engineer – Drive security transformation at Microsoft. Leverage 10+ years of technical pre-sales or solution architecture expertise to serve as a strategic advisor for top-tier customers across the US. Collaborate with C-suite executives, field sellers, and engineeri...
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United States, Multiple Locations
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Salary
139900.00 - 304200.00 USD / Year
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Microsoft Corporation
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Principal AI Solutions Architect
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Principal AI Solutions Architect role in San Francisco: own strategic enterprise accounts, architecting production AI infrastructure with Kubernetes, Istio, and LLM gateways. You’ll drive deep adoption, resolve critical issues hands-on, and shape agent-to-agent communication patterns. Requires 5+...
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170000.00 - 260000.00 USD / Year
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Strategic Employment Partners
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Principal Customer Experience Program Manager
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Microsoft 365 seeks a Principal Customer Experience Program Manager to lead customer engagement and drive competitive wins. You will translate deep customer insights into product improvements, operating at the intersection of engineering, sales, and partners. This role requires 6+ years in techni...
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Location
United States, Multiple Locations
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Salary
142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Security Engineer
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Principal Security Engineer role at Zillow, shaping security across applications, cloud, and AI-enabled systems. Requires 7+ years in security engineering, application security, and AI security initiatives. Lead threat modeling, secure design reviews, and penetration testing for AWS environments....
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Salary
160200.00 - 269400.00 USD / Year
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Zillow
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Principal Engineer, Engineering AI Productivity
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Principal Engineer, Engineering AI Productivity – Lead AI-driven agentic workflows and automation at Confluent, a leader in real-time data streaming. This remote US role requires 8+ years in SaaS/Cloud, deep distributed systems expertise, and hands-on AI/LLM integration. Drive strategic productiv...
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Salary
285000.00 - 342000.00 USD / Year
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Confluent
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About the Principal role

A Principal role represents a senior leadership position found across various industries, from construction and engineering to technology and product management. Individuals in these jobs are trusted with high-level strategic oversight, complex problem-solving, and driving significant organizational impact. Unlike entry-level or mid-career positions, Principal jobs typically require a deep well of specialized expertise, a proven track record of leadership, and the ability to influence direction without direct managerial authority over every team member.

In a professional context, a Principal is often the highest individual contributor or a senior team lead responsible for shaping the vision and execution of critical initiatives. For example, in design and construction sectors, a Principal Designer focuses on risk management from the earliest stages of a project. They ensure that health and safety regulations, such as the CDM Regulations 2015, are integrated into the design process, mitigating hazards before construction begins. This involves leading cross-functional coordination, conducting design reviews, and ensuring a seamless handover to contractors.

In technology and business strategy, Principal Product Managers own the end-to-end lifecycle of complex service portfolios or product lines. They are responsible for defining strategy, developing business cases, and launching innovative offerings that drive customer adoption and revenue growth. These roles demand a data-driven approach to decision-making, strong cross-functional leadership, and the ability to influence executives and stakeholders across engineering, sales, marketing, and customer success teams. Common responsibilities include market analysis, competitive benchmarking, pricing strategy, and building go-to-market plans.

Typical skills required for Principal jobs include exceptional communication and presentation abilities, strategic thinking, and a high degree of autonomy. Candidates usually possess a bachelor’s or master’s degree in a relevant field, combined with significant experience—often eight or more years in a related domain. Technical proficiency is critical, whether in understanding network security, cloud infrastructure, or construction regulations. Soft skills such as negotiation, mentorship, and the ability to drive alignment in matrixed organizations are equally important.

Ultimately, Principal jobs are about leading from the front, solving the most challenging problems, and setting the standard for excellence within an organization. Whether mitigating risk on a construction site or defining the future of a software platform, these professionals are integral to driving meaningful, lasting results.