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Principal United States Jobs (On-site work)

646 Job Offers

Process Development Principal Scientist
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Lead analytical development for late-phase clinical programs at Amgen in Cambridge, MA. As a Process Development Principal Scientist, you will define control strategies, drive method optimization, and support cGMP manufacturing. Requires a PhD with 3+ years industry experience in small molecule a...
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141836.95 - 191897.05 USD / Year
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Amgen
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Principal GTM Strategist
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Appian seeks a Principal GTM Strategist to shape its AI automation market narrative in McLean, VA. This senior role requires 10-15+ years in B2B narrative strategy and C-suite partnership. You will translate complex AI capabilities into executive business value, own messaging AI notebooks, and dr...
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150000.00 - 300000.00 USD / Year
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Appian Corporation
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Principal Associate, Contract Manager
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Join Capital One as a Principal Associate, Contract Manager in McLean, Chicago, Richmond, Plano, New York, or Riverwoods. Leverage your 2+ years of contract drafting, negotiation, and legal experience to drive deal strategies and manage supplier transactions. Collaborate within a inclusive ESM te...
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United States, McLean, Chicago, Richmond, Plano, New York, Riverwoods
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Not provided
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Capital One
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Principal Software Engineer – Test Automation
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Principal Software Engineer – Test Automation role at Baxter in Bellevue, WA. Drive life-saving medical product quality by designing scalable test automation frameworks using Python, Java, or C/C++. Requires 7+ years SDET experience, expertise in PyTest, Selenium, or Robot Framework, and API test...
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112000.00 - 154000.00 USD / Year
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Baxter
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Senior Principal Controls Engineer
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Senior Principal Controls Engineer sought by Baxter in Round Lake, IL to lead automation and digital transformation in a life-saving manufacturing environment. This onsite role requires 8+ years of experience with Allen-Bradley PLCs, robotics, and vision systems, plus a Bachelor's in Engineering....
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Salary
128000.00 - 176000.00 USD / Year
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Baxter
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Senior Principal Controls Engineer
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Senior Principal Controls Engineer sought in Round Lake, IL to drive automation and reliability in life-saving medical device manufacturing. Leverage expertise in Allen-Bradley PLCs, robotics, and vision systems to optimize equipment and lead digital transformation. Requires 8+ years in manufactu...
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128000.00 - 176000.00 USD / Year
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Baxter
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Principal Associate, Accounting
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United States, Richmond, VA, McLean, VA
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109900.00 - 137900.00 USD / Year
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Capital One
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Senior Principal Controls Engineer
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Senior Principal Controls Engineer role in Round Lake, US, driving automation and Industry 4.0 initiatives in a manufacturing site. Requires 8+ years of experience with Allen-Bradley PLCs, robotics, and vision systems. You will optimize equipment reliability, lead CAPAs, and support digital trans...
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128000.00 - 176000.00 USD / Year
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Baxter
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Principal Engineer, Power Density
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Principal Engineer, Power Density – Austin, TX. Lead next-gen energy storage innovation within Enphase’s CTO office. Drive the power density roadmap by attacking all loss mechanisms (conduction, switching, magnetic, thermal) and integrating with mechanical teams for footprint reduction. Requires ...
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130000.00 - 226000.00 USD / Year
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Enphase Energy
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System Interoperability and Integration Engineer Principal
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Principal System Interoperability & Integration Engineer needed for Platform One at Peterson AFB, Colorado. Requires TS/SCI clearance, 7+ years integration experience, and 5+ years DevOps with DORA metrics. Lead automated metrics modeling, configure Party Bus pipelines, and enhance continuous del...
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Astrion
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Principal Product Manager - Tech
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Lead product innovation at Amazon Ads as a Principal Product Manager, driving generative AI-powered ad experiences across Amazon.com. Based in Seattle, New York, or Palo Alto, you will define the long-term vision for conversational ads, manage roadmap strategy, and launch high-impact features. Re...
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United States, Seattle, New York, Palo Alto
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Salary
206900.00 - 279900.00 USD / Year
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Amazon Pforzheim GmbH
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Principal Software Engineer – Test Automation
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Principal Software Engineer – Test Automation role in Bellevue, WA. Drive quality for life-saving medical technology at Baxter. Requires 7+ years in SDET, expertise in Python/Java, and frameworks like Selenium or PyTest. Lead test strategies, automation, and API testing with benefits starting day...
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112000.00 - 154000.00 USD / Year
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Baxter
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Sr. Principal Systems Engineer
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128000.00 - 176000.00 USD / Year
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Baxter
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Sr. Principal Systems Engineer
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Lead system architecture and risk management for life-saving medical devices as a Sr. Principal Systems Engineer at Baxter in Skaneateles Falls, NY. Drive New Product Development and sustainment within the Front Line Care portfolio, leveraging deep expertise in ISO 14971 and IEC 62304. This role ...
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Location
United States, Skaneateles Falls
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Salary
128000.00 - 176000.00 USD / Year
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Baxter
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Principal Program Manager
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United States, Bellevue, Overland Park
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103100.00 - 186000.00 USD / Year
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T-Mobile
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Principal Client Partner, Enterprise
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119700.00 - 216000.00 USD / Year
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T-Mobile
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Principal Enterprise Data Architect
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Principal Enterprise Data Architect sought in Los Angeles to lead end-to-end cloud-native data platform design. Requires 7+ years building enterprise data platforms with Snowflake or Databricks, plus expertise in data governance, AI solutions, and healthcare interoperability. Drive strategic road...
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139215.00 - 229704.00 USD / Year
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L.A. Care Health Plan
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Principal Data Scientist
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Join Microsoft Advertising as a Principal Data Scientist in Redmond, WA. You will solve complex marketplace challenges, define metrics, and design experiments to drive data-informed decisions. We seek a PhD or Master’s in Data Science, Statistics, or related field with deep experience in statisti...
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142800.00 - 274800.00 USD / Year
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Microsoft Corporation
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Principal Software Engineer
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165600.00 - 296400.00 USD / Year
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Microsoft Corporation
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Principal Product Manager
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Principal Product Manager role shaping portfolio strategy and enterprise decision-making in Bellevue, WA. Requires 10+ years of agile product management experience, strategic thinking, and AI fluency. Owns multi-year product vision, KPI frameworks, and cross-org stakeholder relationships. Benefit...
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133800.00 - 241400.00 USD / Year
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T-Mobile
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About the Principal role

A Principal role represents a senior leadership position found across various industries, from construction and engineering to technology and product management. Individuals in these jobs are trusted with high-level strategic oversight, complex problem-solving, and driving significant organizational impact. Unlike entry-level or mid-career positions, Principal jobs typically require a deep well of specialized expertise, a proven track record of leadership, and the ability to influence direction without direct managerial authority over every team member.

In a professional context, a Principal is often the highest individual contributor or a senior team lead responsible for shaping the vision and execution of critical initiatives. For example, in design and construction sectors, a Principal Designer focuses on risk management from the earliest stages of a project. They ensure that health and safety regulations, such as the CDM Regulations 2015, are integrated into the design process, mitigating hazards before construction begins. This involves leading cross-functional coordination, conducting design reviews, and ensuring a seamless handover to contractors.

In technology and business strategy, Principal Product Managers own the end-to-end lifecycle of complex service portfolios or product lines. They are responsible for defining strategy, developing business cases, and launching innovative offerings that drive customer adoption and revenue growth. These roles demand a data-driven approach to decision-making, strong cross-functional leadership, and the ability to influence executives and stakeholders across engineering, sales, marketing, and customer success teams. Common responsibilities include market analysis, competitive benchmarking, pricing strategy, and building go-to-market plans.

Typical skills required for Principal jobs include exceptional communication and presentation abilities, strategic thinking, and a high degree of autonomy. Candidates usually possess a bachelor’s or master’s degree in a relevant field, combined with significant experience—often eight or more years in a related domain. Technical proficiency is critical, whether in understanding network security, cloud infrastructure, or construction regulations. Soft skills such as negotiation, mentorship, and the ability to drive alignment in matrixed organizations are equally important.

Ultimately, Principal jobs are about leading from the front, solving the most challenging problems, and setting the standard for excellence within an organization. Whether mitigating risk on a construction site or defining the future of a software platform, these professionals are integral to driving meaningful, lasting results.