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Principal United States, Chicago Jobs

43 Job Offers

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Principal Research Scientist I, Biologics Analytical Research and Development, CMC Biologics Development
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Lead biologics characterization as Principal Research Scientist at AbbVie in North Chicago. Requires PhD with 6+ years industry experience and expertise in mass spec and separation-based analytical techniques.
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abbvie
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Sr Principal Engineer, Process
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Lead process engineering workstreams at AbbVie in North Chicago. Requires an engineering degree, 8+ years in pharmaceutical formulation, and strong project management skills to drive process improvements and validation.
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Principal Consultant – Bank ALM
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Principal Consultant - Bank ALM in Chicago. Advise bank executives and boards on balance sheet strategy, interest rate risk, liquidity, and ALM. Requires 10+ years of banking experience and strong executive communication skills.
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Strata Decision Technology
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Principal, Customer Education GTM
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Lead GTM strategy for Snowflake's education portfolio in Chicago. Requires 8+ years in product marketing or GTM, cross-functional influence, and data-driven mindset. Define positioning, demand gen, and sales enablement for On Demand learning.
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Snowflake
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Principal Research Scientist I, Biologics Drug Product Development
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Lead biologics drug product development at AbbVie in North Chicago. Seeking BS/MS/PhD with 6-14+ years in pharmaceutics or related fields, expertise in formulation, sterile manufacturing, and tech transfer.
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abbvie
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Principal Customer Success Executive
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Lead high-complexity transformations for ServiceNow's largest strategic customers as a trusted C-suite advisor in Chicago. Drive value management, identify pipeline opportunities, and shape executive customer strategy.
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Armis
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[SY 27-28] Principal-In-Residence
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Lead school-wide vision and coach teachers as Principal-In-Residence at KIPP Chicago. Requires 2+ years as assistant principal, 5 years teaching experience, and a commitment to equity. Competitive benefits.
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KIPP Jacksonville Public Schools
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Principal Data Engineer, AI Enablement
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Lead AI-ready data solutions at AbbVie in North Chicago as Principal Data Engineer. Requires MLOps, LLM integration, Graph RAG, Python, SQL, and Spark expertise. Shape pharma's AI future with cutting-edge data pipelines.
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Principal Research Scientist I, Process Chemistry (Biocatalysis)
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Lead biocatalysis innovation at AbbVie in North Chicago. Seeking a Principal Research Scientist with expertise in enzyme engineering, HTE, and AI/ML to drive API process development. PhD with 6+ years or BS/MS with 12-14+ years.
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[SY 27-28] Principal-In-Residence
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Lead school-wide vision and coach teachers as Principal-In-Residence at KIPP Chicago. Requires 2+ years as assistant principal, 5 years teaching experience, and a commitment to educational equity.
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KIPP Jacksonville Public Schools
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Principal Technical Lead, External Manufacturing - Drug Substance
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Lead technical oversight for external drug substance manufacturing partners at AbbVie in North Chicago. Requires 14+ years experience, GMP expertise, CMO/CDMO management, and strong stakeholder influence skills.
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Principal Solutions Consultant
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Lead technical sales as a Principal Solutions Consultant at LinkedIn in Chicago, NYC, or San Francisco. Requires 7+ years in SaaS product, consulting, or enterprise sales and a related bachelor's degree.
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LinkedIn
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Principal Research Scientist I, Process Chemistry
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Principal Research Scientist II
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Principal Engineer
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Principal Research Scientist I, Process Chemistry (Biocatalysis)
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Principal Research Scientist II Data
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Principal Research Scientist I - Analytical R&D
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Senior Principal Pathologist
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Principal Engineer
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About the Principal role

A Principal role represents a senior leadership position found across various industries, from construction and engineering to technology and product management. Individuals in these jobs are trusted with high-level strategic oversight, complex problem-solving, and driving significant organizational impact. Unlike entry-level or mid-career positions, Principal jobs typically require a deep well of specialized expertise, a proven track record of leadership, and the ability to influence direction without direct managerial authority over every team member.

In a professional context, a Principal is often the highest individual contributor or a senior team lead responsible for shaping the vision and execution of critical initiatives. For example, in design and construction sectors, a Principal Designer focuses on risk management from the earliest stages of a project. They ensure that health and safety regulations, such as the CDM Regulations 2015, are integrated into the design process, mitigating hazards before construction begins. This involves leading cross-functional coordination, conducting design reviews, and ensuring a seamless handover to contractors.

In technology and business strategy, Principal Product Managers own the end-to-end lifecycle of complex service portfolios or product lines. They are responsible for defining strategy, developing business cases, and launching innovative offerings that drive customer adoption and revenue growth. These roles demand a data-driven approach to decision-making, strong cross-functional leadership, and the ability to influence executives and stakeholders across engineering, sales, marketing, and customer success teams. Common responsibilities include market analysis, competitive benchmarking, pricing strategy, and building go-to-market plans.

Typical skills required for Principal jobs include exceptional communication and presentation abilities, strategic thinking, and a high degree of autonomy. Candidates usually possess a bachelor’s or master’s degree in a relevant field, combined with significant experience—often eight or more years in a related domain. Technical proficiency is critical, whether in understanding network security, cloud infrastructure, or construction regulations. Soft skills such as negotiation, mentorship, and the ability to drive alignment in matrixed organizations are equally important.

Ultimately, Principal jobs are about leading from the front, solving the most challenging problems, and setting the standard for excellence within an organization. Whether mitigating risk on a construction site or defining the future of a software platform, these professionals are integral to driving meaningful, lasting results.