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Vice President, Global RWE and HEOR Strategy

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Beam Therapeutics

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Location:
United States , Cambridge

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Category:
IT - Administration

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Contract Type:
Employment contract

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Salary:

310000.00 - 400000.00 USD / Year
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Job Description:

Beam is seeking a dynamic, visionary, and strategic Vice President, Global RWE and HEOR Strategy to spearhead the global HEOR strategy for our sickle cell disease program (risto-cel) and other pipeline programs as they emerge. Sitting within the Medical Affairs function, in this high-impact role, the Vice President, Global RWE and HEOR Strategy will develop and execute evidence-generation plans, manage stakeholder relationships, and shape external communication strategies. You will partner closely with Clinical Development, Medical Communications and Scientific Publications, Value and Evidence Strategy, Commercial, R&D, and additional cross-functional teams.

Job Responsibility:

  • Provide strategic input to disease prioritization, target product profiles, clinical trial protocols, clinical development plans, and regulatory submissions
  • lead development of clinical sections for Investigator’s Brochures, briefing books, safety updates, IND/NDA materials, and responses to Health Authority questions
  • Develop, validate, and integrate patient‑centered outcomes (PROs) into protocols and analyses
  • Interpret clinical trial results (including PROs and healthcare resource use) and partner with Clinical Development/Biostatistics on Statistical Analysis Plans (SAPs) and post‑hoc analyses
  • Lead a fit‑for‑purpose RWE strategy (EHR, claims, registries, hybrid/open datasets) including natural history/registry design and governance to inform endpoints, recruitment, and post‑authorization effectiveness/safety assessments
  • Develop and operationalize external/synthetic control arm approaches (e.g., matched registry cohorts, Bayesian borrowing) for single‑arm or small‑population studies typical in cell & gene therapy
  • Provide operational oversight of Medical Affairs evidence generation, including vendor/CRO governance, milestone/deliverable tracking, data‑quality plans, risk management, and on‑time execution across Medical Affairs–led studies
  • contribute to long‑term capability building (digital health, real‑world studies)
  • Elicit and integrate perspectives from patients, KOLs, policy leaders, and internal stakeholders (market access, marketing, patient advocacy) to ensure plans meet the needs of patients, HCPs, and payers
  • Support Market Access on internal and external payer/policy initiatives (pricing and reimbursement, unmet medical need, regional market dynamics, evidence gaps) across the portfolio
  • Support business decisions around ex-US strategy including, but not limited to, scoping ex-US opportunities, prioritizing country engagement, early scientific advice / parallel consultations with EMA and HTA bodies (e.g., HTACG/JSC), providing advice to development programs on endpoint selection to support product and reimbursement approvals ex-US, etc
  • Anticipate payer evidence needs and budget‑impact critiques (including preparation for ICER Reviews)
  • Build and maintain economic models (cost‑effectiveness, budget impact) tailored to one‑time CGTs, addressing uncertainty/durability and caregiver burden
  • Collaborate with Market Access to design innovative payment models and outcomes‑based agreements with pragmatic outcomes and tracking
  • Lead the AMCP dossier and pre‑approval information exchange (PIE) strategy (6–12 months pre‑launch)
  • Work collaboratively with internal teams, consultants, and CROs to advance development of the portfolio

Requirements:

  • Master’s Degree or higher in Health Economics and Outcomes Research or a relevant discipline
  • Formal training in Epidemiology/Health Services Research required
  • 20+ years’ experience in observational research study management AND data analytics, either within industry or with an observational research consulting firm
  • Proven track record in drug development, with rare disease experience and an existing network of hematologists preferred
  • Demonstrated ability to lead in a matrixed, cross-functional environment, combining strategic agility with strong business acumen
  • Independent, proactive operator with strong ownership
  • Cross functional collaboration with Clinical, Regulatory, Commercial, Medical Operations, and Publications while maintaining medical/scientific integrity
  • Excellent communication, collaboration, and problem-solving skills

Nice to have:

  • rare disease experience
  • existing network of hematologists

Additional Information:

Job Posted:
May 20, 2026

Employment Type:
Fulltime
Work Type:
Hybrid work
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