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Tissue Autoradiography Scientist

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Location:
United States , Madison

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

Not provided
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Job Description:

The Nirschl and Kolb laboratories at the University of Wisconsin–Madison invite applications for a Scientist I or II to contribute to the discovery and development of novel PET imaging tracers targeting pathological protein aggregates in neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, frontotemporal dementia, and ALS. These efforts support multi-institutional collaborations focused on improving early diagnosis and therapeutic development.

Job Responsibility:

  • Lead discovery/optimization by setting up and executing custom tissue-based assays, including autoradiography and radioligand-binding assays, competition assays, and immunoassays or immunostaining, to evaluate compound binding affinity and specificity in human and animal biospecimens
  • Conduct radioligand displacement studies, immunohistochemical validation, and biochemical extraction of pathological proteins from brain tissue
  • Conduct surface plasmon resonance (SPR) experiments to quantify molecular interactions
  • Support lead compound optimization and translational imaging biomarker validation

Requirements:

  • Demonstrated expertise in tissue assay development, protein biochemistry, or molecular imaging
  • Ability to work in a collaborative, interdisciplinary environment
  • Track record of outstanding research accomplishments
  • Ability to work in a highly collegial and collaborative academic environment
  • Broad knowledge base in bioassay development
  • Histopathological characterization of brain tissue samples
  • Tissue homogenization, biochemical extraction and purification of pathological proteins from brain tissue samples
  • Radioligand binding assays using tissue slices, homogenates, and purified proteins
  • Autoradiography experiments for evaluating tracer binding
  • Surface Plasmon Resonance measurements for assessing molecular interactions

Additional Information:

Job Posted:
January 05, 2026

Employment Type:
Fulltime
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