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Thermo Fisher Scientific’s Large Molecule Business Unit (LMBU) is a global Contract Development and Manufacturing Organization (CDMO) supporting customers in bringing biologic therapies to patients. The Sr. Manager – Commercial Systems and Strategy is a key leader within the Commercial Operations Office, responsible for designing, operating, and continuously improving the systems, planning processes, and capability frameworks that enable disciplined commercial execution across the BU. This role serves as a hands-on owner and integrator of enterprise planning, demand planning, and commercial capability development. The Sr. Manager ensures commercial inputs are structured, credible, and actionable—and that teams are trained, aligned, and enabled to execute consistently at scale.
Job Responsibility
Support and execute the commercial components of Long Range Planning (LRP), Annual Operating Plan (AOP), and strategic planning cycles
Develop and maintain planning templates, assumptions, calendars, and governance mechanisms
Consolidate and validate commercial inputs to ensure consistency, accuracy, and alignment with BU strategy
Partner with Finance, Sales, and Business Management to translate strategy into executable plans and targets
Prepare planning outputs, analyses, and insights for leadership reviews
Own commercial inputs into SIOP and demand planning processes
Structure demand signals to ensure they are credible, timely, and aligned with operational planning needs
Partner with Supply Chain, Operations, and Finance to improve alignment between demand forecasts and capacity planning
Identify gaps, risks, and variability in demand signals and recommend mitigation actions
Support continuous improvement of demand planning tools, cadence, and governance
Support the commercial systems roadmap, ensuring tools effectively enable planning, forecasting, and performance tracking
Serve as a functional expert for commercial planning and forecasting systems
Partner with IT and enterprise teams to improve system usability, data quality, and integration
Develop standard reports, dashboards, and analytics to support decision-making
Design and deploy role-based training for commercial systems, planning processes, and governance standards
Develop onboarding materials, standard work documentation, and learning pathways for commercial-facing roles
Partner with functional leaders to assess capability gaps and prioritize development initiatives
Promote consistent adoption of tools, processes, and best practices through structured learning and reinforcement
Identify opportunities to simplify, standardize, and improve commercial planning and execution processes
Support change management for new systems, processes, and planning approaches
Track adoption, effectiveness, and benefits realization for commercial initiatives
Act as a day-to-day integrator across Commercial Operations, Business Management, Sales, Finance, and Operations
Ensure clear communication of expectations, timelines, and standards across planning and execution activities
Escalate risks and misalignment early with data-driven insights and recommendations
Requirements
Bachelor’s degree in business, finance, engineering, or scientific discipline required
MBA or advanced business degree preferred
8–10 years of experience in commercial operations, business management, finance, supply chain, or enterprise planning roles
Experience supporting or leading planning cycles (LRP, AOP) and/or SIOP processes
Experience in pharmaceutical, biotechnology, or CDMO environments preferred
Demonstrated experience working in matrixed, cross-functional organizations
Strong understanding of enterprise planning, demand planning, and commercial operations
Systems-oriented thinker with comfort working in planning and forecasting tools
Highly organized with strong attention to detail and follow-through
Analytical mindset with ability to translate data into insights
Effective communicator able to influence without formal authority
Comfortable operating between strategy and execution
Passion for building scalable processes, tools, and organizational capability
What we offer
Choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
Variable annual bonus based on company, team, and/or individual performance results