Sr. Systems Engineer Job at 10x Genomics (Pleasanton)

Sr. Systems Engineer

10x Genomics

Location:
United States , Pleasanton

Category:
IT - Software Development

Contract Type:
Not provided

Salary:

168900.00 - 228500.00 USD / Year

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Job Description:

As a System Engineer at 10x, you will be involved in all aspects of the product development process, from the initial ideation and requirements generation to prototyping to launch. System engineers develop instrument architectures, conceive and run system-level models, and design & implement custom hardware systems and associated metrology and testing approaches. You will work closely with hardware engineers including mechanical, electrical, optical and fluidic groups and collaborate cross-functionally with software, chemistry and computational biology teams.

Job Responsibility:

Develop, model, document, and refine platform and instrument architectures
Support architecture implementation with subject matter experts and engineers in sub-system teams
Develop models that allow for data-driven decisions on products, simulating tradeoffs between performance of instruments and consumables, and product COGS.
Conceive and implement system-level tests for new instruments, and work with discrete design teams ensure that sub-system and component level testing is appropriate to verify new designs against performance and reliability requirements
Engage with technical team members to identify and resolve key technical challenges
Facilitate cross-functional interactions throughout the product development life cycle, including the management of relationships with internal and external stakeholders
Collaborate with stakeholders and technical teams to develop end user workflows
Conduct routine risk assessments (e.g., FMEAs) and work with leadership to define and execute risk mitigation plans
Provide technical leadership throughout the product development process
run design reviews and lead technical efforts at project and platform levels

Requirements:

Bachelors in an engineering discipline (Comp Sci, Mechanical, Electrical, etc)
masters preferred
5+ years working with the design, integration, or testing of hardware systems or instruments
Direct experience in a cross-functional role (e.g., systems engineer, project lead)
Experience in system modeling for performance/cost tradeoffs, including prior experience with product cost modeling
Proficiency in Python
comfort implementing moderate complexity in silico models and associated visualizations (e.g., in Jupyter notebooks)
Fluency with modern AI tools (chat platforms and software development tools)
Strong analytical, problem-solving, and organizational skills
Excellent visual & oral communication and presentation skills
Ability to pick up new technologies quickly
Self-motivated
able to work independently in a fast paced, dynamic environment

Nice to have:

Experience with standards such as UL 61010-1, UL 60601-1, ISO 9001, ISO 13485
Demonstrable understanding of design of experiment and statistical analysis of test data
Experience debugging and extending (e.g., through scripting) hardware control software, particularly in Linux environments
Experience building organizational processes, templates, standards, etc.

What we offer:

equity grants
comprehensive health and retirement benefit programs
annual bonus program or sales incentive program
competitive and comprehensive health benefits package
competitive easy-to-use benefits that promote wellbeing
family friendly policies like parental leave
generous time off

Additional Information:

Job Posted:
March 22, 2026

Employment Type:

Fulltime

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