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Sr Scientist

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Amgen

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Location:
United States , Thousand Oaks

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Category:
Research and Development

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Contract Type:
Employment contract

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Salary:

127121.75 - 171988.25 USD / Year
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Job Description:

We are seeking a motivated Senior Scientist in mass spectrometry-based proteomics to join our talented and collaborative team in Thousand Oaks, CA. In this vital role, you will deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies. You will contribute to both pipeline advancement and screening platform innovation by developing and implementing cutting-edge, high-throughput proteomics approaches. This includes executing automated sample preparation and mass spectrometry analyses across a range of assays, as well as designing, optimizing, and continuously enhancing next-generation screening workflows and analytical platforms. This role requires hands-on experience operating and troubleshooting high-throughput mass spectrometry systems.

Job Responsibility:

  • Deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies
  • Contribute to both pipeline advancement and screening platform innovation by developing and implementing cutting-edge, high-throughput proteomics approaches
  • Execute automated sample preparation and mass spectrometry analyses across a range of assays
  • Design, optimize, and continuously enhance next-generation screening workflows and analytical platforms
  • Collaborate closely with chemistry, biology, and disease area teams as a technical and scientific subject matter expert, contributing to data-driven decision-making
  • Perform data analysis and generate insights into mechanism of action, target engagement, and selectivity using proteomics approaches
  • Present research findings at internal and external meetings and effectively communicate plans, results, and analyses to cross-functional teams
  • Maintain accurate and organized documentation of experiments, protocols, and analyses

Requirements:

  • Doctorate degree (PhD, PharmD, or MD) with relevant experience
  • Master's degree and 4 years of directly related experience
  • Bachelor's degree and 6 years of directly related experience
  • Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, or a related discipline
  • Strong track record in developing mass spectrometry-based proteomics assays, operating advanced platforms (e.g., Orbitrap Astral), and analyzing proteomics data
  • Experience with sample preparation miniaturization and automation platforms
  • 3+ years of experience in the biotech or pharmaceutical industry
  • Demonstrated innovation in assay, method, or platform development
  • Strong quantitative and computational expertise in high-dimensional proteomics data analysis
  • Ability to work effectively in a highly integrated, collaborative team environment, with excellent organizational, verbal, and written communication skills, and a proven track record of producing reliable and reproducible results
  • Knowledge of targeted protein degradation or E3 ligase biology is a plus

Nice to have:

Knowledge of targeted protein degradation or E3 ligase biology is a plus

What we offer:
  • Health and welfare plans for staff and eligible dependents
  • Financial plans with opportunities to save towards retirement or other goals
  • Work/life balance
  • Career development opportunities
  • Retirement and Savings Plan with generous company contributions
  • Group medical, dental and vision coverage
  • Life and disability insurance
  • Flexible spending accounts
  • Discretionary annual bonus program
  • Stock-based long-term incentives
  • Award-winning time-off plans

Additional Information:

Job Posted:
April 24, 2026

Employment Type:
Fulltime
Work Type:
On-site work
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