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Senior Software Engineer

United States, Menlo Park 190081.00 - 211201.00 USD / Year · Job Posted February 13, 2026
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Job Description

Ready to redefine what's possible in molecular diagnostics? Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary—a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion—every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong. We are currently looking for a high-performing Senior Software Engineer to join our dynamic software engineering Oncology team. Software engineers at BillionToOne work in highly collaborative and interdisciplinary teams of clinicians, computational biologists, and other engineers to robustly scale personalized genomic medicine to millions of patients. If you have experience performing in a full life-cycle development, love seeing your work positively affect your colleagues and patients, and thrive in a fast-paced entrepreneurial environment, this could be a great opportunity for you. In this role, you can have an impact both through many small tools and large product development. This role is a hybrid (onsite 2-3 days/week) position.

Job Responsibility

  • Collaborate with talented engineers to design and develop our backend services, data processing pipelines, and interfaces, driving innovation and efficiency
  • Build user-facing features to optimize performance and reliability, enhancing overall user experience
  • Elevate BTO Oncology’s backend systems, including the test order record database, third-party integrations, test scheduling and reports management software, and distributed systems architecture, to ensure they meet the highest standards
  • Demonstrate a creative and out-of-the-box mindset, offering innovative solutions and approaches to complex technical challenges
  • Prioritize quality by writing comprehensive unit / integration / end-to-end tests and ensuring superior test coverage across all components and modules. Highly skilled in writing technical documentation and validation reports that assure correct functionality of medical informatics systems
  • Demonstrate a strong sense of ownership and take responsibility for end-to-end project delivery. The ideal candidate will thrive in an environment where they have the autonomy to make informed decisions and take the initiative to drive projects forward
  • Collaborate cross-functionally, actively seeking input from team members and fostering a positive and inclusive work environment

Requirements

  • 5+ years of professional software development experience with a proven track record of delivering complex projects and adhering to best practices
  • Expertise in Python backend frameworks (e.g., Django or Flask), delivering high-quality, scalable code
  • Strong foundation in cloud services, preferably AWS, including ECS, S3, AWS Batch, EC2, and AWS Lambda, enabling effective architecture and management of complex systems
  • Familiarity with modern AI-driven development practices and tools
  • Excellent communication and collaboration skills, with the ability to work effectively in a team-oriented environment
  • Proven track record of building products and features from conception to deployment, showcasing your ability to innovate and deliver results

Nice to have

  • Experience in healthcare-related software or a passion for improving healthcare systems
  • Experience working at a fast-paced startup or high-growth company
  • Familiarity with healthcare data standards, such as FHIR and HL7
  • Experience with medical software and authoring technical verification / validation reports
  • Experience leveraging AI-assisted coding and debugging tools
  • Experience building AI agents, fine-tuning machine learning models, or deploying LLM-based applications

What we offer

  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options
  • employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Daily on-site lunches provided from top eateries
  • A variety of perks on campus (state of the art gym, restaurant)
  • Free on-site EV charging (compatible with all EVs, including Tesla)
  • Generous equity options offering
  • Corporate bonus program

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