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Senior Scientist

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Proclinical

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Location:
United States , Tarrytown

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

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Job Description:

Advance the future of therapeutics by unlocking molecular insights through cutting‑edge mass spectrometry. Proclinical is seeking a Senior Scientist specializing in Analytical and Biological Mass Spectrometry to join a dynamic team in the US. This is a contract role with the potential for extension or conversion. The successful candidate will focus on supporting research and development programs through advanced mass spectrometry techniques, particularly for the characterization of novel therapeutic modalities and monoclonal antibodies.

Job Responsibility:

  • Develop LC-MS-based analytical methods to support research and development programs
  • Perform LC-MS data analysis using bioinformatic tools to characterize therapeutic proteins and other novel modalities
  • Conduct sample preparation and LC-MS experiments independently, adhering to standard operating procedures (SOPs)
  • Document experimental results in electronic laboratory notebooks (ELNs) and present findings in group meetings
  • Write technical reports, SOPs, and contribute to regulatory filing documents
  • Summarize results in formats such as graphs, figures, and tables for presentations, publications, and regulatory submissions
  • Support regulatory applications and deepen understanding of antibody therapeutics and emerging modalities

Requirements:

  • Proficiency in LC-MS-based sample preparation for proteins and peptides
  • Experience with specialized LC-MS techniques such as hydrogen-deuterium exchange mass spectrometry (HDX-MS) and quantitative proteomics is a plus
  • Knowledge of AAV virology, structural biology, enzyme function, and kinetics is advantageous
  • Strong verbal and written communication skills, along with excellent interpersonal abilities
  • Ability to learn new technologies, solve problems, and work effectively in a fast-paced, team-oriented environment
  • A passion for science and a results-driven mindset
  • Master's degree or higher in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field

Nice to have:

  • Experience with specialized LC-MS techniques such as hydrogen-deuterium exchange mass spectrometry (HDX-MS) and quantitative proteomics
  • Knowledge of AAV virology, structural biology, enzyme function, and kinetics

Additional Information:

Job Posted:
April 05, 2026

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