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Senior Scientist - Oligonucleotide Synthesis

Sweden, Uppsala · Job Posted June 09, 2026
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Job Description

We are looking for a Senior Scientist to join our team in Uppsala. As part of Nucleic Acids R&D, you will play a key role in developing innovative products that are used in the manufacturing of leading biological drugs. Your work will span the full development lifecycle—from idea generation and research to development and continuous improvement—while also contributing to troubleshooting and optimisation of existing Cytiva processes. The Uppsala site is a key hub within Cytiva, with more than 1,500 employees across functions such as manufacturing, marketing, quality control, and quality assurance. Collaboration is therefore central to this role, and you will work closely with cross-functional partners to drive projects forward and deliver high-quality solutions. You will join the Nucleic Acids section within the Genomic Medicine Operating Company, R&D Uppsala. Our team consists of 16 researchers working across production, purification, filtration, and analytical characterisation of nucleic acids, supporting product development to meet our customers’ needs. We are now looking to strengthen the team with an expert in oligonucleotide synthesis who can bring deep technical expertise and contribute to our continued innovation.

Job Responsibility

  • Act as a subject matter expert in oligonucleotide synthesis, including phosphoramidite chemistry, solid supports, and synthesis optimization
  • Conduct analysis and method-related work in new product development, product care, and market support projects, with a strong customer focus
  • Develop analytical methods to characterize oligonucleotides such as HPLC, LCMS or mass spectrometer
  • Lead and own the automated oligonucleotide synthesis workflow, including instrument configuration, method setup, advanced troubleshooting, and performance optimization across different oligo sequences and applications
  • Lead method development, optimization, verification, and validation activities, ensuring robustness, reproducibility, and alignment with design control and regulatory expectations
  • Independently plan, execute, and document experimental work in a structured manner
  • Present and communicate results at project meetings, in customer interactions, and occasionally through posters or oral presentations at conferences
  • Act as a technical advisor to customer-facing and commercial teams, supporting complex customer queries related to oligonucleotide synthesis and nucleic acid workflows

Requirements

  • PhD (5+ years experience) or BSc/MSc (8+ years experience) in chemistry, biochemistry, biotechnology preferable from industry experience
  • Hands-on experience in oligonucleotide synthesis, including phosphoramidite chemistry and solid support synthesis
  • Experience with method development, verification, and validation, preferably in a regulated or industrial R&D environment
  • Experience configuring automated oligonucleotide synthesizer including synthesis protocols and instrument settings and troubleshooting both chemistry- and hardware-related issues
  • Collaborative, structured, and self-driven, and enjoy working in a dynamic, cross-functional, and customer-focused environment
  • Strong presentation and communication skills, with advanced proficiency in English (written and spoken)
  • Valid Swedish work permit

Nice to have

  • Experience working in design control
  • Experience working with chromatography systems and UNICORN™ software

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