Senior Scientist, LNP Sciences

• Responsible for formulation design, development, characterization, and technology transfer to enable development of Beam sterile drug products
• Accountable as an individual contributor to support formulation development as well as providing necessary guidance and support of drug product control strategy for drug candidates across all stages of development
• Independently design, execute, analyze, and document experiments to optimize LNP potency, tolerability, biodistribution, and ligand conjugation
• Design and execute experiments to enable a robust and reproducible process for manufacture of ligand conjugated LNPs at-scale
• Interface closely with Analytical Development and Biotherapeutics teams to characterize different unit operations for the manufacturing of DP to understand process robustness
• Provide support with tech transfer activities for manufacturing of drug products
• Generate high quality documentation as per Beam SOPs and in support of regulatory filings
• Communicate scientifically rigorous findings via verbal and written communications, and presentations both internally and externally

• PhD or MS in Pharmaceutical Sciences, Chemical Engineering, Bioengineering or related field with drug product and CMC development experience (PhD 4+ years or MS 12+ years)
• Deep understanding of sterile product development
• Prior industry research experience, especially in nucleic acids and drug delivery, is required
• Experience with development of antibody-drug conjugates and/or biologics is preferred
• Knowledge of statistical techniques and concepts (regression, properties of distributions, statistical tests, and proper usage, etc.)
• Ability to adapt to increasing scope and complexity of work brought on by growth/change and help others manage through change
• Excellent computational, written, and verbal communication skills, strong organizational abilities, and an ability to work with a diverse group of scientists and engineers
• Ability to work in a hybrid environment with sufficient on-site presence

Experience with development of antibody-drug conjugates and/or biologics