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This position will be reporting into the Early Formulation Science and Drug Delivery group at the La Jolla, California location. In this position you will act as a resident pharmaceutical science subject matter expert to influence small molecule early drug candidate selection with respect to drug delivery, bio-performance, and stability. You will closely collaborate with colleagues in Medicinal Chemistry, Pharmacokinetics & Drug Metabolism, and Clinical Pharmacology. You will be responsible for designing, implementing, and interpreting in vitro, in silico, and in vivo experiments, as well as design of stage-appropriate traditional and enabled formulations for preclinical studies. In addition to formulation, you will be responsible for material science and physicochemical properties assessments of early drug candidates. This includes laboratory measurements and interpretation of the data to inform manufacturing, bio-performance, and stability risks for development of the drug candidates.
Job Responsibility:
Evaluate the physicochemical properties of potential small molecule drug candidates to inform a drug product formulation strategy and developability risk assessment
Design and develop fit for purpose and diagnostic traditional and enabled formulations for preclinical studies
Design, execute, and interpret the results of polymorph and salt screens for potential drug candidates related to stability, manufacturability, and bio-performance
Apply first principles understanding of thermodynamics and kinetic processes to dissolution and precipitation of drugs in biorelevant conditions and physical and chemical stability in the solid state
Work in cross-disciplinary teams and partner with subject matter experts in Medicinal Chemistry, Pharmacokinetics & Drug Metabolism, and Clinical Pharmacology departments to influence candidate selection and progression
Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to the pharmaceutical sciences
Conduct novel research and present significant findings via internal and external presentations or publications
Requirements:
Recent PhD with 0-3 year post-doctoral experience, MS with 7+ years experience, or BS with 8+ years experience in Chemistry, Chemical Engineering, Physical Chemistry, Physics, Physical Organic Chemistry, Pharmaceutics, or Pharmaceutical Sciences
Experience working independently and collaboratively in a laboratory environment
Nice to have:
Experience in designing and conducting hypothesis driven laboratory experiments
Experience with application of fundamental principles to solve complex problems
Generating, interpreting, and integrating experimental data into mathematical models to progress the understanding of complex materials and processes
Experience in pharmacokinetic modeling and simulations using Gastroplus or similar modeling software
Experience with data structuring and capture
Experience with formulation design for preclinical studies as well as awareness of drug product design criteria for phase 1 clinical trials
Strong organizational skills, interpersonal skills, teamwork skills, strong written and verbal communication skills
Ability to prioritize and manage multiple projects and activities while managing tight timelines
What we offer:
401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
paid vacation, holiday and personal days
paid caregiver/parental and medical leave
health benefits to include medical, prescription drug, dental and vision coverage
participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary
eligibility to participate in our share based long term incentive program