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Cranleigh STEM Logo Cranleigh STEM · Research and Development

Senior Scientist - Downstream Analytics

United Kingdom, Southampton 45000.00 - 55000.00 GBP / Year · Job Posted January 08, 2026
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Job Description

Senior Scientist – Downstream Analytics (Large Molecules). We’re partnering with an innovative scientific organisation to recruit a Senior Scientist with strong experience in downstream analytical processes, including HPLC and bioprocessing techniques, to join a high-performing team based in Southampton. This hands-on role offers the chance to support the development of modified nucleic acids and peptides, drive analytical method development, and contribute to the advancement of large molecule therapeutics in a collaborative, fast-paced environment. You’ll take the lead on analytical workflows for nucleic acids, peptides, and antibodies, ensuring high standards of quality, compliance, and scientific rigour. The role will include method development, instrument maintenance, and cross-functional collaboration across R&D and production teams. This position is ideal for a scientist who enjoys working across disciplines, mentoring junior colleagues, and staying at the forefront of analytical innovation.

Job Responsibility

  • Lead downstream analytical workflows using HPLC, UPLC, PAGE, flash chromatography, and related techniques
  • Contribute to the purification and characterisation of large molecules, such as peptides and antibodies
  • Support method development and continuous improvement in analytical approaches
  • Collaborate with chemistry and production teams to support small molecule and oligonucleotide preparation
  • Maintain, calibrate, and optimise analytical instrumentation in line with ISO and internal quality systems
  • Mentor and support Associate Scientists and Lab Technicians
  • Ensure accurate documentation and maintain data integrity across workflows
  • Promote and uphold Health, Safety, and Environmental (HSE) standards
  • Manage stock levels of analytical reagents and consumables
  • Stay up to date on emerging trends in bioprocessing and analytical technologies

Requirements

  • A PhD (or equivalent experience) in Analytical Chemistry, Biochemistry, or a related field
  • Strong hands-on experience in HPLC and bioprocessing within a biotechnology, pharmaceutical, or life sciences environment
  • Knowledge of purification and characterisation methods for peptides, antibodies, or similar large molecules
  • Experience with TFF or tangential flow filtration (advantageous)
  • Familiarity with ISO or GMP-regulated environments
  • Ability to lead technical projects and support team development
  • Strong communication and problem-solving skills
  • A flexible, proactive mindset with strong attention to detail

Nice to have

Experience with TFF or tangential flow filtration

What we offer

  • Holidays: 25 days annual leave + 8 bank holidays
  • Pension: 6% employer contribution
  • Life Assurance: 4x salary
  • Flexible working hours
  • Long service awards and recognition scheme
  • Employee Assistance Programme with 24/7 remote GP access
  • Annual flu vaccinations
  • Cycle to work scheme and gym discounts
  • Discounts and savings platform
  • Professional membership reimbursement
  • Referral incentives
  • Social events and volunteering days
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