CrawlJobs Logo

Senior Scientist, Diagnostic Assay Development

10xgenomics.com Logo

10x Genomics

Location Icon

Location:
United States , Pleasanton

Category Icon

Job Type Icon

Contract Type:
Not provided

Salary Icon

Salary:

158400.00 - 214400.00 USD / Year

Job Description:

10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. We are seeking a highly skilled and motivated Senior Scientist to join the Diagnostic Assay Development team. This is a hands-on bench scientist role with scientific ownership of assay development and optimization, combined with mentorship and technical leadership of junior staff. The Senior Scientist will directly execute, troubleshoot, and refine 10x Genomics–based assays to support development of robust Laboratory Developed Tests (LDTs).

Job Responsibility:

  • Assay Development & Execution: Independently execute complex single-cell and spatial genomics workflows
  • Serve as a hands-on technical expert for 10x Genomics platforms
  • Systematically troubleshoot and optimize assay workflows
  • Adapt, refine, and extend published protocols
  • Design and execute feasibility studies
  • Process diverse and challenging clinical sample types
  • Analytical Validation & Documentation: Design and execute experiments supporting analytical validation
  • Generate, review, and maintain high-quality laboratory documentation
  • Analyze assay performance metrics and quality control data
  • Clearly present experimental data and scientific conclusions
  • Scientific Leadership & Mentorship: Provide day-to-day technical guidance and mentorship to junior staff
  • Review experimental plans, data, and lab records
  • Support onboarding and training of new team members
  • Lead by example through hands-on bench work
  • Cross-Functional Collaboration: Collaborate closely with R&D Scientists, Automation Engineers, Bioinformatics, and CLIA Operations teams
  • Lead transfer of optimized assay workflows into the CLIA laboratory
  • Work with lab operations to maintain a high-quality laboratory environment

Requirements:

  • Ph.D. in Molecular Biology, Genetics, Biochemistry, or a related field, or M.S. with equivalent industry experience
  • 3+ years (Ph.D.), 5+ years (M.S.) of hands-on industry experience in molecular diagnostics or genomics assay development
  • Extensive, direct hands-on experience with 10x Genomics single-cell and/or spatial technologies, including troubleshooting and optimization
  • Demonstrated ability to independently adapt and refine published molecular biology protocols
  • Strong background in NGS workflows, including nucleic acid extraction, PCR/qPCR, and library preparation
  • Experience working with complex or low-input clinical samples (e.g., FFPE tissue, primary tumor material)
  • Experience with cell culture methods

Nice to have:

  • Prior mentoring or supervisory experience preferred
  • Experience working in CLIA, CAP, or ISO 13485–regulated environments strongly preferred
  • Experience with automation or high-throughput workflows is a plus
What we offer:
  • Equity grants
  • Comprehensive health and retirement benefit programs
  • Annual bonus program or sales incentive program
  • Generous time off
  • Competitive and comprehensive health benefits package
  • Family friendly policies like parental leave

Additional Information:

Job Posted:
March 13, 2026

Employment Type:
Fulltime
Job Link Share:

Looking for more opportunities? Search for other job offers that match your skills and interests.

Briefcase Icon

Similar Jobs for Senior Scientist, Diagnostic Assay Development

Senior Bioinformatics Scientist

We are looking for a Senior Bioinformatics Scientist to join a fast growing team...
Location
Location
United States , Menlo Park
Salary
Salary:
156060.00 - 176868.00 USD / Year
billiontoone.com Logo
BillionToOne
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related fields
  • 2+ years of experience developing robust and scalable bioinformatics pipelines
  • 2+ years of experience analyzing NGS data
  • Fluency in Python
  • Experience with Linux environment, GitHub and AWS
  • Excellent communication and presentation skills, ability to work across functional teams and with non-experts
Job Responsibility
Job Responsibility
  • Develop sophisticated and robust NGS analysis pipelines capable of processing tens of thousands of samples
  • Develop tests and test frameworks for NGS pipelines
  • Analyze and troubleshoot clinical NGS data
  • Analyze assay performance and contribute to publications that demonstrate the clinical validity and utility of our tests
  • Design new quality metrics and processes for clinical molecular diagnostic assays
  • Collaborate with R&D scientists to generate new scientific insights
  • Communicate assay performance and capabilities to clinical personnel at weekly meetings and to other non-clinical stakeholders
What we offer
What we offer
  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options
  • employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Fulltime
Read More
Arrow Right

Research Associate

Ready to redefine what's possible in molecular diagnostics? Join a team of brill...
Location
Location
United States , Menlo Park
Salary
Salary:
73920.00 - 84480.00 USD / Year
billiontoone.com Logo
BillionToOne
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • BS or MS in Molecular and Cell Biology, Microbiology, Biophysics, Biochemistry, or related field
  • 1-2 years of research experience (either during BS/MS or afterwards)
  • Previous experience with standard molecular biology techniques (in particular, extensive experience with PCR, electrophoresis, DNA purifications)
  • An ability to quickly learn mathematical, analytical, and experimental concepts
  • High mathematical and statistical aptitude (e.g., you find GRE math section to be extremely easy)
  • Great attention to detail
Job Responsibility
Job Responsibility
  • Perform experiments and assays under the guidance of Senior Scientists
  • Learn analytical and computational methodologies and analyze the results under the guidance of Senior Scientists
  • Assist Senior Scientists in assay development
  • Keep accurate and meticulous records of experimental details and results
  • Prepare biological samples and reagents to accelerate the R&D process
  • Manage, organize, and support lab operations
What we offer
What we offer
  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options
  • employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Fulltime
Read More
Arrow Right

Research Associate

Ready to redefine what's possible in molecular diagnostics? Join a team of brill...
Location
Location
United States , Menlo Park
Salary
Salary:
73920.00 - 84480.00 USD / Year
billiontoone.com Logo
BillionToOne
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • BS or MS in Molecular and Cell Biology, Microbiology, Biophysics, Biochemistry, or related field
  • 1-2 years of research experience (either during BS/MS or afterwards)
  • Previous experience with standard molecular biology techniques (in particular, extensive experience with PCR, electrophoresis, DNA purifications)
  • An ability to quickly learn mathematical, analytical, and experimental concepts
  • High mathematical and statistical aptitude (e.g., you find GRE math section to be extremely easy)
  • Great attention to detail
Job Responsibility
Job Responsibility
  • Perform experiments and assays under the guidance of Senior Scientists
  • Learn analytical and computational methodologies and analyze the results under the guidance of Senior Scientists
  • Assist Senior Scientists in assay development
  • Keep accurate and meticulous records of experimental details and results
  • Prepare biological samples and reagents to accelerate the R&D process
  • Manage, organize, and support lab operations
What we offer
What we offer
  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options
  • employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Fulltime
Read More
Arrow Right

Senior Laboratory Manager

Talentmark are recruiting for a Senior Laboratory Manager to join a Life Science...
Location
Location
United Kingdom , Macclesfield
Salary
Salary:
70000.00 - 73000.00 GBP / Year
ckgroup.co.uk Logo
CK Group
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Educated to PhD level ideally
  • Extensive experience in a high-throughput clinical DNA Sequencing laboratory
  • Experience with clinical assay development, process development and project management
  • Proven track record in team leadership, staff development and laboratory management
  • Strong background in Quality Assurance and Quality Control applications in clinical diagnostics
  • Detail-oriented, highly organized, with excellent verbal and written communication skills
  • Ability to troubleshoot technical applications and manage laboratory automation systems
  • Strong knowledge of quality control practices and regulations of UKAS, ISO 15189, CAP and other regulatory agencies
Job Responsibility
Job Responsibility
  • Oversee testing of clinical samples and supervise, mentor, and develop laboratory staff, including scientists, technicians and support personnel
  • Lead a high-throughput clinical genome sequencing laboratory, including technical troubleshooting, developing and writing operational procedures, setting laboratory key performance indicators and establishing quality metrics
  • Design and implement processes and procedures to ensure efficient turnaround times and accuracy of results and oversee daily laboratory operations, including workflow optimization, resource allocation and equipment maintenance
  • Prepare and manage laboratory budgets, monitor expenditures and optimize resource utilization
  • Ensure all processes comply with national regulations, organizational policies and accreditation requirements and maintain ISO 15189, CAP and other accreditation standards, including preparation for audits and inspections
  • Lead initiatives for process improvement and communicate effectively with internal and external stakeholders
  • Fulltime
Read More
Arrow Right

Senior Laboratory Manager

CK Group are recruiting for a Senior Laboratory Manager to join a Life Sciences ...
Location
Location
United Kingdom , Macclesfield
Salary
Salary:
70000.00 - 73000.00 GBP / Year
ckgroup.co.uk Logo
CK Group
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Educated to PhD level ideally
  • Extensive experience in a high-throughput clinical DNA Sequencing laboratory
  • Experience with clinical assay development, process development and project management
  • Proven track record in team leadership, staff development and laboratory management
  • Strong background in Quality Assurance and Quality Control applications in clinical diagnostics
  • Detail-oriented, highly organized, with excellent verbal and written communication skills
  • Ability to troubleshoot technical applications and manage laboratory automation systems
  • Strong knowledge of quality control practices and regulations of UKAS, ISO 15189, CAP and other regulatory agencies
Job Responsibility
Job Responsibility
  • Oversee testing of clinical samples and supervise, mentor, and develop laboratory staff, including scientists, technicians and support personnel
  • Lead a high-throughput clinical genome sequencing laboratory, including technical troubleshooting, developing and writing operational procedures, setting laboratory key performance indicators and establishing quality metrics
  • Design and implement processes and procedures to ensure efficient turnaround times and accuracy of results and oversee daily laboratory operations, including workflow optimization, resource allocation and equipment maintenance
  • Prepare and manage laboratory budgets, monitor expenditures and optimize resource utilization
  • Ensure all processes comply with national regulations, organizational policies and accreditation requirements and maintain ISO 15189, CAP and other accreditation standards, including preparation for audits and inspections
  • Lead initiatives for process improvement and communicate effectively with internal and external stakeholders
  • Fulltime
Read More
Arrow Right

Senior Scientist, Reagents Sustaining and Applications

We are seeking a Senior Scientist to join the Reagent Sustaining and Application...
Location
Location
United States , Pleasanton
Salary
Salary:
158400.00 - 214400.00 USD / Year
10xgenomics.com Logo
10x Genomics
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • BS, MS or PhD in molecular biology, biochemistry, genetics, microbiology, analytical chemistry, or related fields
  • 12+ years (BS), 10+ years (MS) or 5+ years (PhD) of relevant experience in reagent or assay development and optimization, preferably in the Biotechnology industry
  • Experience analyzing large-scale single-cell or spatial transcriptomics datasets to derive biologically meaningful insights and/or diagnostic biomarkers
  • Ability to design and execute experiments to measure the impact of process improvements and/or formulation changes
  • Experience with a broad variety of molecular biology and analytical techniques including qPCR, nucleic acid isolation, use of plate readers, Bioanalyzers, gel imagers, real-time PCR instruments, etc.
  • Experience with single cell assays including cell handling, library preparation and downstream analysis
  • Experience investigating, identifying, documenting, communicating, and resolving quality control issues in a controlled manufacturing environment
  • Experience defining, documenting, communicating, and transferring new manufacturing workflows into controlled manufacturing environments
  • Meticulous attention to detail and a conscientious work ethic
Job Responsibility
Job Responsibility
  • Lead efforts in testing new materials, tools, and workflows to improve 10x’s state-of-the-art products
  • Collaborate with key internal and external partners to troubleshoot and mitigate any issues that may arise in 10x’s Chromium product line
  • Design and execute experiments to assess the impact of protocol, reagent, or process changes on 10x’s Assays
  • Design, test, and implement process improvements in 10x’s Chromium product line
  • Perform statistical analyses on key assay and QC metrics
  • Update manufacturing documents and present results
What we offer
What we offer
  • Equity grants
  • Comprehensive health and retirement benefit programs
  • Annual bonus program or sales incentive program
  • Competitive and comprehensive health benefits package
  • Easy-to-use benefits that promote wellbeing
  • Family friendly policies like parental leave
  • Generous Time Off
  • Fulltime
Read More
Arrow Right

Senior Application Scientist, Test Implementation and Support

The Sr. Technical Services Application Scientist is responsible for providing ou...
Location
Location
United States , Phoenix
Salary
Salary:
67000.00 - 119000.00 USD / Year
exactsciences.com Logo
Exact Sciences
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Ph.D. in a life sciences field
  • Master’s degree in a life sciences field and 2 years of life sciences industry experience in lieu of Ph.D.
  • or Bachelor’s Degree in life sciences or related field and 4 years of life sciences industry experience in lieu of Ph.D.
  • 3+ years of experience in the life sciences industry or a related field
  • 3+ years of experience analyzing data with tools such as Microsoft Office Excel or JMP
  • 2+ years of experience working in a molecular diagnostics/clinical laboratory
  • Professional working knowledge or coursework with molecular biology techniques and Real-Time-PCR Assays
  • Strong understanding of statistical and mathematical methods in biology/genetics
  • Proficient in Microsoft Office, especially Excel
  • Authorization to work in the United States without sponsorship
Job Responsibility
Job Responsibility
  • Receive and document incoming customer communications
  • Work cooperatively with the Technical Services team and internal functional departments to troubleshoot and resolve customer questions or requests
  • Lead troubleshooting of customer issues through root cause investigation, experiment design, study execution, data analysis, and reporting
  • Conduct bench level experiments within several product areas
  • Prepare technical experiment report with all technical specification and information and present to supervisor or project team
  • Coordinate with the Development and Marketing teams for proper implementation of new products
  • Clearly and accurately summarize and document troubleshooting activities or technical summary
  • Prepare detailed technical protocols
  • Communicate customer feedback regarding their product requirements to the developmental team
  • Assist with metrics tracking to monitor performance of the technical services team and quality of the product
What we offer
What we offer
  • Paid time off (including days for vacation, holidays, volunteering, and personal time)
  • Paid leave for parents and caregivers
  • A retirement savings plan
  • Wellness support
  • Health benefits including medical, prescription drug, dental, and vision coverage
  • Bonus eligibility
  • Fulltime
Read More
Arrow Right

Biomedical Scientist

Are you an experienced Biomedical Scientist with expertise in Immunology, seekin...
Location
Location
United Kingdom , South London
Salary
Salary:
20.00 - 25.00 GBP / Hour
https://hg-ahp.com Logo
Hunter Gatherer AHP
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Extensive experience in Immunology and Virology, particularly with laboratory testing techniques such as PCR, ELISA, and viral culture
  • Strong knowledge of laboratory practices, specimen preparation, and analysis
  • Excellent communication skills and the ability to work effectively within a team
  • A commitment to providing accurate, high-quality diagnostic services
  • Full right to work in the UK (we are unable to provide sponsorship)
Job Responsibility
Job Responsibility
  • Conducting immunology and virology lab tests, including PCR, ELISA, and serological assays
  • Preparing and processing patient samples for analysis, ensuring high standards of accuracy
  • Collaborating with senior staff to interpret results and provide expert guidance
  • Maintaining laboratory equipment and ensuring all procedures meet regulatory standards
  • Assisting in the development and implementation of quality control measures
  • Working closely within a multidisciplinary team to provide exceptional patient care
What we offer
What we offer
  • Fast and easy AHP locum registration – start working quickly
  • A network of like-minded AHP professionals
  • Reliable, high-paying locum jobs with bi-weekly payroll
  • Specialist AHP recruitment consultants who understand your field
  • Exclusive job opportunities across the NHS and private sectors
  • CV marketing, business development support, and more
  • Networking events, industry insights, and discounted CPD opportunities
  • Fulltime
Read More
Arrow Right