Senior Scientist- Process Chemistry Job at 10x Genomics (Pleasanton)

Senior Principal Scientist: Process Chemistry

Lead the chemistry behind tomorrow's medicines by driving world‑class drug subst...

Location

United States , Palo Alto

Salary:

Not provided

Proclinical

Expiration Date

Until further notice

Requirements

Ph.D. in Organic Chemistry with 8+ years of relevant industry experience in process chemistry
Strong expertise in synthetic chemistry, scale-up, and cGMP manufacturing
Working knowledge of QbD principles, PAT, risk management, and regulatory expectations
Proven experience managing CDMOs and CROs
Demonstrated ability to operate independently and influence cross-functional teams in a fast-paced development environment
Excellent problem-solving, communication, and project management skills
Up to ~20% travel, primarily to CDMO sites

Job Responsibility

Serve as the technical point of accountability for drug substance programs, ensuring alignment across CMC, Quality, Regulatory, and external partners
Lead route selection, process development, optimization, and impurity control strategies
Lead and manage CDMOs from proposal evaluation and selection through GMP manufacturing, release, and delivery
Characterize drug substance properties and support form selection activities
Review and approve batch records and oversee external manufacturing quality and compliance
Troubleshoot process issues and drive continuous improvement initiatives with internal and external teams
Prepare comprehensive tech transfer packages and support analytical method development
Guide chemical development strategy from early-stage programs through commercialization
Author and review technical sections for IND, IMPD, and other global regulatory submissions
Partner with Project Management and Finance to support cost, timeline, and risk management for drug substance programs

Process Development Senior Scientist

Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part...

Location

United States , Cambridge

Salary:

123777.00 - 167463.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree PhD OR PharmD OR MD and relevant post-doc where applicable completed by August 2026
OR Master's degree and 3 years of Scientific experience
OR Bachelor's degree and 5 years of Scientific experience

Job Responsibility

Design and develop synthetic routes and scalable chemical processes for the manufacture of synthetic and hybrid drug substances
Develop safe, robust, efficient, and cost-effective manufacturing processes suitable for clinical and commercial production
Advance enabling technologies that accelerate pharmaceutical development and improve sustainability, efficiency, and process robustness
Support cGMP manufacturing activities and assist with technology transfer efforts to internal manufacturing sites and external contract manufacturing organizations (CMOs)
Build process understanding through experimentation, process characterization, modeling, and data analysis to ensure consistent process performance
Contribute to cross-functional drug substance development teams by providing technical expertise, experimental data, scientific recommendations, and clear documentation
Collaborate across disciplines to support regulatory filings and author technical sections of regulatory documentation
Stay current with advances in synthetic organic chemistry, process chemistry, and related technologies, and apply new scientific insights to ongoing programs
Effectively collaborate within multidisciplinary teams that include chemists, engineers, analytical scientists, and other technical experts
Independently manage project activities and deliver high-quality results within established timelines

What we offer

Health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Work/life balance
Career development opportunities
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives

Fulltime

Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part...

Location

United States , Thousand Oaks

Salary:

126066.05 - 170559.95 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
OR Master’s degree and 3 years of Scientific experience
OR Bachelor’s degree and 5 years of Scientific experience

Job Responsibility

Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to invent synthetic routes and develop safe, robust, sustainable and cost-effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
Ensure process performance through process understanding, modeling and characterization
Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc
Work cross-functionally to deliver regulatory documents and support regulatory filings
Serve as a technical expert and keep current in the field of bioconjugation, antibody drug conjugate, oligonucleotide, peptide, and process chemistry and manufacturing
Work independently in advancing projects and studies within required deadlines

What we offer

Health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Work/life balance
Career development opportunities
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives

Fulltime

Senior Scientist – Dough

Pizza Hut is looking for a highly driven Senior Food Scientist to support produc...

Location

United States

Salary:

99200.00 - 116700.00 USD / Year

Yum!

Expiration Date

Until further notice

Requirements

Bachelor’s degree in Food Science, Food Engineering, Chemistry or related field – with a preferred concentration in wheat/grains/bakery science
5+ years of experience in product development, R&D, or food manufacturing environments
Experience within large scale global QSR or CPG environments
Experience working with fresh and frozen doughs a plus
Strong understanding of food formulation, ingredient functionality, food processing and quality systems
Exposure to process optimization, commercialization and sensory science and ability to proactively and positively interface with various cross functional and technical teams
Ability to flawlessly execute bench work
Must be proactive, reliable and self-motivated
Passion for food innovation and emerging industry trends
Ability to manage priority tasks with little supervision

Job Responsibility

Lead product development and reformulation initiatives from concept through commercialization
Develop and optimize formulations, ingredients, and manufacturing processes to improve product quality, consistency, shelf life, cost efficiency, and to improve overall product experience to consumer
Conduct bench trials, plant trials, sensory evaluations, and product validations
Partner with cross-functional teams including Quality Assurance, Operations, Supply Chain, and Marketing to ensure successful product launches and continuous improvement
Analyze product performance, market trends, and competitor products to identify innovation opportunities
Support scale-up activities and ensure products are manufacturable within operational capabilities
Maintain accurate documentation related to formulations, specifications, testing, and process validations
Collaborate with suppliers to evaluate ingredients, troubleshoot challenges, and identify alternative solutions when needed
Ensure compliance with food safety, regulatory, and quality standards throughout all stages of development
Manage project timelines and communicate progress effectively with key stakeholders

What we offer

bonus eligibility

Fulltime

Senior Chemistry Engineer

We are looking for a Senior Chemistry Engineer for one of our clients.

Location

United Kingdom , Bristol

Salary:

Not provided

Lobellia

Expiration Date

Until further notice

Requirements

Degree-qualified Engineer or Scientist in Chemistry, Chemical Engineering, or a related scientific discipline
Proven experience in nuclear chemistry during commissioning and plant operation phases (minimum 5 years)
Strong understanding of water-steam chemistry, radiochemistry, and chemical control in nuclear power plant systems.
Demonstrated experience in EPR projects (experience on OL3, FA3, or similar plants is a strong advantage).
Good knowledge of system and process engineering principles relevant to nuclear plant operations.
Experience working within multi-disciplinary teams on large, complex engineering projects.
Familiarity with nuclear safety culture, operational constraints, and quality requirements in regulated environments.
English fluent (minimum B2)

Job Responsibility

Support the production of the commissioning documentation associated within the chemistry scope of the project.
Support the wider commissioning team regarding all questions in interface with Chemistry of the Nuclear Island during the different phase of the commissioning.
Support the customer for any question related to the preparation of the test execution.
Provide needed support to the Commissioning Engineering Team (CET) by clarifying the Open Points raised by the On-site commissioning team.
Coordinate with the different stakeholder for the survey of the technical inputs required for the production of the commissioning document related to Chemistry such as the Technical specification.
Confirm the project data & internal organization with the discipline Lead (budget, time schedule, author – checker – approver)
Identify the relevant stakeholders and means
Check the maturity of the input data against reference configuration and/or upcoming changes
Collect OPEX
Record risks in the related register and propose mitigation plan, if any

Fulltime

Senior Scientist, Reagents Sustaining and Applications

We are seeking a Senior Scientist to join the Reagent Sustaining and Application...

Location

United States , Pleasanton

Salary:

158400.00 - 214400.00 USD / Year

10x Genomics

Expiration Date

Until further notice

Requirements

BS, MS or PhD in molecular biology, biochemistry, genetics, microbiology, analytical chemistry, or related fields
12+ years (BS), 10+ years (MS) or 5+ years (PhD) of relevant experience in reagent or assay development and optimization, preferably in the Biotechnology industry
Experience analyzing large-scale single-cell or spatial transcriptomics datasets to derive biologically meaningful insights and/or diagnostic biomarkers
Ability to design and execute experiments to measure the impact of process improvements and/or formulation changes
Experience with a broad variety of molecular biology and analytical techniques including qPCR, nucleic acid isolation, use of plate readers, Bioanalyzers, gel imagers, real-time PCR instruments, etc.
Experience with single cell assays including cell handling, library preparation and downstream analysis
Experience investigating, identifying, documenting, communicating, and resolving quality control issues in a controlled manufacturing environment
Experience defining, documenting, communicating, and transferring new manufacturing workflows into controlled manufacturing environments
Meticulous attention to detail and a conscientious work ethic

Job Responsibility

Lead efforts in testing new materials, tools, and workflows to improve 10x’s state-of-the-art products
Collaborate with key internal and external partners to troubleshoot and mitigate any issues that may arise in 10x’s Chromium product line
Design and execute experiments to assess the impact of protocol, reagent, or process changes on 10x’s Assays
Design, test, and implement process improvements in 10x’s Chromium product line
Perform statistical analyses on key assay and QC metrics
Update manufacturing documents and present results

What we offer

Equity grants
Comprehensive health and retirement benefit programs
Annual bonus program or sales incentive program
Competitive and comprehensive health benefits package
Easy-to-use benefits that promote wellbeing
Family friendly policies like parental leave
Generous Time Off

Fulltime

Senior Scientist, Early Formulation Science and Drug Delivery, Drug Product Design

This position will be reporting into the Early Formulation Science and Drug Deli...

Location

United States , La Jolla

Salary:

90900.00 - 151500.00 USD / Year

Pfizer

Expiration Date

Until further notice

Requirements

Recent PhD with 0-3 year post-doctoral experience, MS with 7+ years experience, or BS with 8+ years experience in Chemistry, Chemical Engineering, Physical Chemistry, Physics, Physical Organic Chemistry, Pharmaceutics, or Pharmaceutical Sciences
Experience working independently and collaboratively in a laboratory environment

Job Responsibility

Evaluate the physicochemical properties of potential small molecule drug candidates to inform a drug product formulation strategy and developability risk assessment
Design and develop fit for purpose and diagnostic traditional and enabled formulations for preclinical studies
Design, execute, and interpret the results of polymorph and salt screens for potential drug candidates related to stability, manufacturability, and bio-performance
Apply first principles understanding of thermodynamics and kinetic processes to dissolution and precipitation of drugs in biorelevant conditions and physical and chemical stability in the solid state
Work in cross-disciplinary teams and partner with subject matter experts in Medicinal Chemistry, Pharmacokinetics & Drug Metabolism, and Clinical Pharmacology departments to influence candidate selection and progression
Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to the pharmaceutical sciences
Conduct novel research and present significant findings via internal and external presentations or publications

What we offer

401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
paid vacation, holiday and personal days
paid caregiver/parental and medical leave
health benefits to include medical, prescription drug, dental and vision coverage
participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary
eligibility to participate in our share based long term incentive program
Relocation support available

Fulltime