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As a Senior Scientist in the Translational Unit, you will play a critical role in bridging preclinical target and asset validation and early clinical proof of concept studies in the immunology and respiratory space, working closely with biology and translational leads, clinical and computational scientists.
Job Responsibility:
Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays, including ELISA-based and flow cytometry-based readouts
Utilise your expertise in immunology to assist in the design, optimisation, and conduct of in vitro and ex vivo translational assays using primary human cells and tissues
Apply expertise in multiple capabilities such as flow cytometry, ELISA/MSD/Luminex, gene/protein expression analysis, cell and tissue imaging, proteomics, and other omics platforms
Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design
Present findings to internal teams and stakeholders in a clear and precise manner while maintaining accurate and detailed laboratory records to ensure compliance with data integrity expectations and safety guidelines
Foster a culture of innovation, collaboration, and continuous learning within the translational research team and ensure compliance with all applicable laws, regulations, and ethical standards
Requirements:
PhD (or MSc with equivalent relevant laboratory experience) in Cell Biology, Molecular Biology, Immunology or related field
Expertise in developing and performing multi-color flow cytometry, gene expression analysis, immunoassays (ELISA, MSD or Luminex), primary cell culture techniques, and biomarker assays
Experience processing human biological samples, developing B cell, T cell and myeloid cell functional readouts, flexibility to adopt new technologies
Ability to understand, interpret, and communicate complex scientific data
Strong written and verbal communication skills, with the ability to effectively present scientific findings to internal and external stakeholders in a balanced, clear, and precise manner. Excellent record keeping and organisational skills
Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards
Nice to have:
Background and expertise in autoimmune, respiratory, and immune-mediated diseases
Previous experience in pharma or biotech industry
understanding of drug discovery processes including small and large molecule development
Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development