CrawlJobs Logo
Amgen Logo Amgen · Research and Development

Senior Scientist – Research Computational Biology Platforms

United States, South San Francisco 146404.00 - 198076.00 USD / Year · Job Posted April 16, 2026
Apply Position
Job Link Share

Job Description

The ARIA Computational Biology team is seeking a talented and creative computational biologist to further our mission of serving patients by advancing and replenishing the Amgen therapeutic pipeline. In this vital role, you will apply your expertise in data science and mechanistic disease biology to develop innovative methods and platforms that accelerate the identification, prioritization, and validation of transformative therapeutic targets within a dynamic, cross-functional research environment.

Job Responsibility

  • Developing and applying methods and platforms to discover, prioritize, and validate targets across a broad range of diseases and therapeutic modalities
  • Designing and building a Precision Targeting Engine that integrates internal and high-value public data into an automated, scalable framework with custom expression analytics across diverse data types and disease areas
  • Contributing to the design and evolution of Amgen’s preclinical omics data ecosystem in partnership with the Research Informatics team
  • Evaluating and integrating emerging AI/ML technologies (e.g., biological foundation models), and developing custom research agents to accelerate early pipeline efforts
  • Partnering with data science and information systems teams to embed tools and analyses developed within ARIA Computational Biology into integrated R&D platforms
  • Training and mentoring other scientists in the use of advanced research tools and platforms

Requirements

  • PhD in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable]
  • Master’s degree in computational biology, bioinformatics, data science, or a related discipline and 3 years of relevant research experience
  • Bachelor’s degree in computational biology, bioinformatics, data science, or a related discipline and 5 years of relevant research experience
  • Strong programming expertise in Python and R, with proficiency in Linux/Unix environments, cloud computing, HPC, and collaborative development practices (e.g., Git)
  • Experience developing complex computational tools and visualizations that translate biological insights into actionable strategies
  • Experience developing and deploying computational tools and pipelines, including use of workflow management systems (e.g., Nextflow), CI/CD practices, and interactive visualization tools (e.g., Shiny/Streamlit)
  • Strong background in molecular and systems biology
  • Demonstrated expertise in the analysis and interpretation of single-cell omics data
  • Experience leveraging and fine-tuning transcriptional foundation models, large language models (LLMs), and biomedical knowledge graphs to advance research objectives
  • Familiarity with high-value public data resources (e.g., DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M) used to complement and enhance analyses of internal datasets
  • Excellent communication and presentation skills, with the ability to convey complex concepts to diverse audiences
  • Self-motivated, collaborative, and committed to continuous learning and growth

What we offer

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
Amgen - All Job Offers

Looking for more opportunities?

Search for other job offers that match your skills and interests.

Suggested Tags: Frontend Developer Secretary Talent Manager Salesforce Administrator Data Analyst
Similar Jobs for

Senior Scientist – Research Computational Biology Platforms

8 matching positions

Senior Scientist – Research Computational Biology

Join Amgen’s Mission of Serving Patients. The ARIA Computational Biology team is...
Location
Location
United States
Salary
Salary:
143320.00 - 174539.00 USD / Year
amgen.com Logo
Amgen
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Doctorate in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable]
  • Master’s degree and 3 years of relevant research experience
  • Bachelor’s degree and 5 years of relevant research experience
  • Strong programming skills (Python, R, Linux/Unix), familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g., Git)
  • Track record of designing and implementing creative and holistic computational strategies to address challenging research questions
  • Demonstrated expertise in the analysis and interpretation of single cell omics data
  • Excellent presentation and communication skills to convey complex findings to diverse audiences
  • Self-starter with a collaborative mentality and a drive for continuous growth
Job Responsibility
Job Responsibility
  • Extracting biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses
  • Developing and leveraging methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities
  • Innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships
  • Partnering with our data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms
What we offer
What we offer
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models, including remote and hybrid work arrangements, where possible
  • Fulltime
Read More
Arrow Right

Senior Bioinformatics Scientist

Job Advert: Senior Bioinformatics Scientist. Our client is an emerging leader wi...
Location
Location
United States , San Francisco
Salary
Salary:
170000.00 - 190000.00 USD / Year
signifytechnology.com Logo
Signify Technology
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • PhD in Biological Sciences, Bioinformatics, Computational Biology, or related field, with 3+ years of experience developing production-level bioinformatics pipelines
  • Deep expertise in analyzing bulk/single-cell RNAseq data and performing differential gene expression using state-of-the-art tools
  • Significant experience building production-level Snakemake (or Nextflow) pipelines, with local and cloud-based deployments
  • Strong knowledge of sequence analysis (alignment, assembly) and molecular biology, with experience in Oxford Nanopore and Illumina sequencing
  • Proficiency in Python (numpy, pandas, Jupyter, Biopython) and package management (e.g., Conda)
  • Hands-on experience with Docker, Apptainer, or Singularity for containerized workflows
  • Expertise in Git/GitHub and Linux shell scripting for version control and automation
  • Proficiency in developing intuitive web tools for bioinformatics reporting (e.g., R Shiny, Streamlit)
  • Familiarity with public genomic data repositories (e.g., NCBI, Ensembl) and large-scale genomic data processing
  • Strong communication skills and ability to write clean, maintainable, production-ready code
Job Responsibility
Job Responsibility
  • Designing and optimizing high-performance bioinformatics pipelines for processing thousands of daily samples, leveraging tools like Snakemake and cloud deployments
  • Innovating sequence analysis workflows for bulk/single-cell RNAseq, differential gene expression, and large-scale genomics, ensuring robust and scalable solutions
  • Troubleshooting complex sequencing data challenges, from biological artifacts to platform-specific issues, to ensure reliable outputs
  • Developing intuitive web tools (e.g., Streamlit, R Shiny) and data visualizations to transform raw bioinformatics data into actionable insights
  • Providing thought leadership and mentoring junior team members, fostering a culture of innovation and collaboration
  • Staying ahead of industry trends, integrating emerging bioinformatics tools to enhance our offerings for biopharma and research clients
What we offer
What we offer
  • Competitive Compensation: Highly competitive remuneration
  • Generous Time Off: 4 weeks paid time off + 10 paid holidays
  • Comprehensive Health Coverage: Health, dental, and vision insurance, plus life insurance and mental health coverage
  • Retirement and Wellness: 401(k) with matching, Health Advocate services, and gym membership
  • Impactful Work: Contribute directly to accelerating biotech research, supporting novel therapies and sustainability
  • Innovative Environment: Work with cutting-edge tools (e.g., Snakemake, Streamlit, AWS) and collaborate with top-tier researchers
  • Supportive Culture: Join a passionate, inclusive team that values creativity, mentorship, and professional growth
  • Fulltime
Read More
Arrow Right

Senior Scientist – Research Computational Biology (ARIA)

Join Amgen’s Mission of Serving Patients. The ARIA Computational Biology team is...
Location
Location
United States , South San Francisco; Boston; Thousand Oaks
Salary
Salary:
146404.00 - 198076.00 USD / Year
amgen.com Logo
Amgen
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • PhD in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable]
  • Master’s degree in computational biology, bioinformatics, data science, or a related discipline and 3 years of relevant research experience
  • Bachelor’s degree in computational biology, bioinformatics, data science, or a related discipline and 5 years of relevant research experience
  • Strong background in cardiometabolic disease and/or immunology, including applications in the interpretation of single-cell data
  • Proficient in extracting actionable mechanistic insights from complex biological datasets through development and creative application of AI/ML-based analytical strategies
  • Strong programming skills (Python, R, Linux/Unix) and experience with cloud computing environments, HPC, and collaborative coding practices (e.g., Git)
  • Track record of designing and executing creative and holistic computational strategies to address challenging research questions
  • Proven expertise in the analysis and interpretation of single-cell omics data
  • Excellent communication and presentation skills, with the ability to convey complex concepts to diverse audiences
  • Self-motivated, collaborative, and committed to continuous learning and growth
Job Responsibility
Job Responsibility
  • Deriving biological insight from complex multi-modal omics and perturbation screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses
  • Conducting innovative, collaborative research in close partnership with Amgen therapeutic area scientists and our Discovery Sciences, Advanced Technologies, and AI (DATA) team, spanning discovery platforms, internal pipeline programs, and external partnerships
What we offer
What we offer
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
  • Fulltime
Read More
Arrow Right

Senior Director – BioIntelligence

The AI & Data for Engineered Biologics (AIDE) organization at Amgen is seeking a...
Location
Location
United States , Thousand Oaks
Salary
Salary:
239775.00 - 295217.00 USD / Year
amgen.com Logo
Amgen
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Doctorate degree in Computational Biology, Machine Learning, Bioinformatics, Computer Science, Biophysics, or related field and 5 years of experience applying machine learning or computational modeling to biological systems
  • OR Master’s degree in Computational Biology, Machine Learning, Bioinformatics, Computer Science, Biophysics, or related field and 9 years of experience applying machine learning or computational modeling to biological systems
  • OR Bachelor’s degree in Computational Biology, Machine Learning, Bioinformatics, Computer Science, Biophysics, or related field and 11 years of experience applying machine learning or computational modeling to biological systems
  • At least 5 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources
Job Responsibility
Job Responsibility
  • Lead the BioIntelligence Team within our Large Molecule Discovery organization, defining strategy and priorities for AI-driven biologics modeling
  • Develop and execute a roadmap for machine learning and AI approaches that accelerate engineered biologics discovery
  • Align BioIntelligence capabilities with broader Research and Large Molecule Discovery priorities
  • Oversee development of predictive models for key biologics properties, including developability, stability, manufacturability, and immunogenicity
  • Advance modeling approaches using modern AI techniques such as: protein language models
  • generative modeling and inverse folding
  • representation learning
  • active learning and Bayesian optimization
  • Guide the use of multimodal biological datasets including sequence, structure, and experimental assay data
  • Lead development of production-quality research software and deployable ML models used across discovery teams
What we offer
What we offer
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
  • Fulltime
Read More
Arrow Right

Target Validation Sr Director

This research based Senior Director role will be responsible for building, leadi...
Location
Location
United States , South San Francisco
Salary
Salary:
265405.00 - 312459.00 USD / Year
amgen.com Logo
Amgen
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Doctorate degree PhD in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 7 years of scientific leadership experience in biotech, pharma or equivalent research environments
  • OR Master’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 10 years of scientific leadership experience in biotech, pharma or equivalent research environments
  • OR Bachelor’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant disciplineand 12 years of scientific leadership experience in biotech, pharma or equivalent research environments
Job Responsibility
Job Responsibility
  • Lead and develop a multidisciplinary organization of ~25 scientists within Research Biology
  • Integrate diverse experimental disciplines and workflows to ensure coordinated execution and efficient delivery of novel molecular insights
  • Establish platform priorities, resource allocation, and capacity planning in alignment with Research Biology and Therapeutic Area priorities
  • Define clear roles, responsibilities, and seamless handoffs across teams and partnering organizations
  • Drive adoption of automated experimental workflows, and integration of AI/ML to enable efficient experimentation across programs
  • Serve as a senior scientific partner to Target Discovery and Therapeutic Areas
  • Set clear expectations and enable scientists with diverse skill sets to collaborate effectively and contribute to early research pipeline
  • Serve as a core member of Target Discovery Advisory Forum, and play a key role in target discovery, validation and prioritization. Engage, influence, and align therapeutic area stakeholders
  • Guide team members in synthesizing and communicating complex scientific and data-driven insights to key stakeholders and advisory forum
  • Contribute to fostering a highly collaborative, creative, dynamic and cutting-edge research environment
What we offer
What we offer
  • competitive benefits
  • collaborative culture
  • health and welfare plans for staff and eligible dependents
  • financial plans with opportunities to save towards retirement or other goals
  • work/life balance
  • career development opportunities
  • Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • Fulltime
Read More
Arrow Right

Director senior director antibody discovery

BigHat is seeking an exceptional and highly experienced individual for a positio...
Location
Location
United States , San Mateo
Salary
Salary:
230000.00 - 270000.00 USD / Year
BigHat Biosciences
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Ph.D. in molecular biology, biochemistry, protein engineering, or related discipline with 12+ years of experience in antibody discovery and engineering within academia, biotechnology, or pharmaceutical industries
  • 8+ years of managerial experience leading scientific teams
  • Strong expertise with protein display systems such as yeast, phage, mammalian, or mRNA display
  • Demonstrated experience with antibody library design, construction, screening, and selection analysis
  • Deep understanding of antibody structure-function relationships and mechanisms of antigen recognition
  • Experience integrating antibody discovery workflows with downstream characterization and developability assessment, including functional screening and biophysical evaluation of antibody candidates
  • Familiarity with computational or ML-enabled approaches to protein design and optimization
  • Experience advancing biologics from early discovery through lead optimization stages
  • Knowledge of diverse antibody modalities including multispecific antibodies, antibody fragments, and other advanced formats
  • Strong leadership skills with experience building and mentoring scientific teams
Job Responsibility
Job Responsibility
  • Lead BigHat’s antibody discovery and display functions, setting the scientific, technical, and strategic direction
  • Oversee the routine execution of display-based selection campaigns to enhance and diversify affinity, developability, and function across diverse antibody formats and antigen types in support of BigHat and BigHat-partnered therapeutic programs
  • Manage and mentor a team of scientists responsible for antibody library design, generation, screening, selection, and early optimization
  • Shape and expand BigHat’s antibody discovery technologies and capabilities, including new display and selection methods, library design strategies, and technical approaches that leverage and enhance the company’s integrated experimental and computational platform
  • Provide scientific leadership across discovery and early optimization efforts, ensuring antibodies emerging from selections possess strong functional and developability characteristics
  • Work closely with leaders in Protein Sciences, Data Science/Machine Learning, Engineering, and Platform groups to ensure seamless progression from discovery through characterization and optimization
  • Collaborate with biology and therapeutic research leads to ensure display outputs align with and advance program objectives
  • Foster a collaborative and high-performance culture within the discovery organization
What we offer
What we offer
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave
  • bonus
  • options
  • Fulltime
Read More
Arrow Right

Engagement Manager

Proteins are the molecular machines of life, used for many therapeutic, diagnost...
Location
Location
Netherlands; Switzerland , Amsterdam; Zürich
Salary
Salary:
Not provided
cradle.bio Logo
Cradle
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Deep understanding of biopharma R&D workflows and the ability to confidently engage with executive stakeholders as well as experimental and computational scientists
  • 5–7+ years in enterprise client-facing roles (program management, consulting, or customer success) ideally in Life Sciences
  • Proven ability to lead complex, multi-stakeholder programs and drive measurable ROI
  • Strong relationship-building, executive presence, crisp communication, and excellent organizational skills
  • Comfortable presenting scientific and business insights to internal and external cross-functional audiences
  • MSc or advanced degree in Molecular Biology, Biotechnology, Bioengineering, or a related field, or equivalent professional experience
  • Willingness to travel to- and work from customer sites (20% of the time)
Job Responsibility
Job Responsibility
  • Oversee post-sale success across global biotech and pharma customers, from initial onboarding to long-term, broad adoption
  • Define and track portfolio-level success metrics and ROI, presenting progress to senior customer stakeholders
  • Establish and lead steering committees to align stakeholders and ensure Cradle delivers measurable impact
  • Understand customer budget cycles, licensing models, and R&D roadmaps to identify timely opportunities for growth and renewals
  • Partner with Account Executives to expand Cradle’s footprint across new business units and therapeutic areas
  • Coordinate with Scientific Advisors to ensure smooth project initiation, resource allocation, and execution within licensed project slots
  • Manage multi-workstream engagements, ensuring alignment across Science, Product, and ML teams
  • Inspire and lead your cross-functional Cradle team to deliver seven star customer experiences
  • Act as the primary escalation and coordination point for enterprise accounts
  • Solicit, capture and communicate customer feedback, driving improvements in Cradle’s product and service delivery
What we offer
What we offer
  • Very competitive salary
  • Generous equity stake (for full time employees)
  • Wide range of benefits
  • Career progression opportunities
  • Fulltime
Read More
Arrow Right
New

Financial Analyst - Entry Level

We are looking for a detail-oriented Financial Analyst - Entry Level to support ...
Location
Location
United States , Los Angeles
Salary
Salary:
Not provided
https://www.roberthalf.com Logo
Robert Half
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Bachelor's degree in Finance, Accounting, Economics, Business, or a related field, or equivalent relevant experience
  • Foundational knowledge of financial analysis principles and basic financial reporting practices
  • Ability to analyze data, interpret findings, and present information in a structured manner
  • Proficiency with spreadsheets and standard business software used for reporting and analysis
  • Strong attention to detail, organizational skills, and ability to manage multiple deadlines in a Contract role
Job Responsibility
Job Responsibility
  • Examine financial data to identify trends, variances, and areas that require further review
  • Prepare recurring and ad hoc reports that summarize performance, budget activity, and key financial findings
  • Use data analysis techniques to organize information, validate accuracy, and support business recommendations
  • Monitor financial market activity and gather relevant information to inform internal reporting needs
  • Work with Bloomberg Terminal resources to collect market data and assist with financial research
  • Support the preparation of forecasts, budget comparisons, and other analytical materials for leadership review
  • Collaborate with internal stakeholders to clarify reporting needs and present information in a clear, useful format
  • Maintain organized financial records and help ensure reporting is completed accurately and on schedule
What we offer
What we offer
  • Medical insurance
  • Vision insurance
  • Dental insurance
  • Life insurance
  • Disability insurance
  • 401(k) plan
Read More
Arrow Right