Senior Research Scientist, Mass Spectrometry

• Design, develop, and validate robust small molecule MS-based assays for drug discovery
• Optimize assay conditions to ensure high sensitivity, specificity, and reproducibility for small molecule detection and quantification
• Collaborate with structural biology and biophysics teams to integrate MS data with structural and biophysical insights
• Work closely with medicinal chemists, biologists, and other scientists to align assay development with project goals
• Ensure compliance with laboratory SOPs and detailed record keeping in an electronic notebook
• Maintain, operate, and troubleshoot LCMS instrumentation for routine and novel assays

• Relevant Ph.D. or equivalent experience with a proven track record of small molecule mass spec delivery
• Experience running and analysing quantitative small molecule mass spec assays
• Practical experience working with triplequad MS platforms
• Hands-on experience troubleshooting complex instrumentation
• It is essential that applicants hold entitlement to work in the UK

Experience of small molecule Affinity Selection Mass Spectrometry (AS-MS) is desirable