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NewLimit is seeking an Senior/Research Associate with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases. Your role will focus on supporting the development of in vitro assays and pre-clinical models to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our scientists as well as our technology-focused teams to help create the first reprogramming medicines for the vascular tissue.
Job Responsibility:
Isolate cells from primary tissues to optimize in vitro functional assays
Develop pre‑clinical models of age-related dysfunction
Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions at scale
Support the development of in vivo nucleic acid delivery methods for endothelial cells
Analyze and interpret experimental data to drive pre-clinical decision making
Requirements:
Bachelor’s degree in cell biology, molecular biology, biochemistry or a related field with 2‑5 years of relevant industry or academic experience
Proficiency in primary mammalian cell culture and animal handling techniques for rodent models
Proficiency in flow cytometry techniques
Exceptional organizational skills, as demonstrated by detailed record-keeping in a lab notebook and an ability to effectively carry out multiple ongoing projects or experiments
Nice to have:
Experience with isolation and functional characterization of primary cells
Experience developing animal models of cell dysfunction and/or injury
Experience with FACS and flow cytometry
Experience using computational tools to automate routine data analysis (e.g. Python, R, etc.)
What we offer:
Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays