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NewLimit is seeking a Senior Research Associate with experience in liver biology or in vivo physiology to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will help develop epigenetic editing tools, functional assays, and model systems to measure the effectiveness of our therapeutic candidates.
Job Responsibility:
Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
Perform experiments in preclinical animal models of liver disease
Conduct functional and phenotypic assays to evaluate the effects of reprogramming on hepatocyte biology in vivo
Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)
Isolate murine and human hepatocytes by liver perfusion with downstream FACS analysis
Requirements:
BS in cell biology, molecular biology, or a related natural science and 2+ years of work experience in a cell biology or animal physiology laboratory (academic or industry setting)
Proficiency in animal handling and husbandry techniques for rodent models (mice or rats)
Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent projects
Experience with standard molecular biology techniques, including gel electrophoresis, nucleic acid purification, and PCR
Nice to have:
Experience working with mouse models of aging, disease and liver dysfunction
Experience with in vivo manipulation of hepatocytes and liver perfusion techniques
Experience with single-cell genomics or other functional genomics approaches
Proficiency in molecular biology and molecular cloning methods
What we offer:
Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays