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We are seeking a skilled and motivated Senior/Research Associate to join our Delivery Sciences team. In this role, you will focus on the formulation, downstream processing, and characterization of lipid nanoparticles (LNPs) to enable our nucleic acid delivery chemistries. The ideal candidate possesses a deep technical understanding of LNP assembly via various mixing methods, expertise in downstream purification, and hands-on experience with advanced analytical characterization techniques.
Job Responsibility:
Formulate, downstream process, and characterize LNPs for nucleic acid delivery across diverse model systems, including pre-clinical models
Partner with the Epigenetic Editing and Product teams (Immunology, Metabolism, Vascular) to meet LNP requirements for reprogramming interventions at both small and large scales
Develop and optimize LNP compositions, downstream processing and analytical methods to establish robust production protocols
Map future formulation needs, manage material procurement, and ensure the lab is equipped for upcoming programs
Interpret complex experimental data to drive decision-making within Delivery Science and Preclinical Development workstreams
Maintain rigorous and detailed records of experimental protocols and results in an Electronic Laboratory Notebook (ELN)
Requirements:
MS in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or a related discipline with 2+ years of industry experience or equivalent experience
Experience formulating LNPs with diverse lipid components for nucleic acid delivery
Experience with purification techniques, including dialysis, Tangential Flow Filtration (TFF), ultracentrifugation, and sterile filtration
Proficiency in LNP analysis using DLS, LC-UV, LC-CAD, CGE, fragment analyzers, Osmolality, MALS, ELISA, and fluorescence-based 96-well plate assays
Nice to have:
Experience contributing to drug product development at the preclinical or clinical stages
Background in liver biology or experience with LNP delivery to hepatocytes
Experience with bioconjugation, surface modification, or adding targeting moieties to LNPs to achieve cell type specificity
Experience with data visualization and statistical analysis (R, Python)
What we offer:
Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays