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Senior Research Associate- Diagnostic Assay Development

United States, Pleasanton 97700.00 - 132100.00 USD / Year · Job Posted June 28, 2026
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Job Description

10x Genomics is establishing a diagnostics effort, translating our leading single cell and spatial assay technologies into impactful clinical applications. We are seeking a highly skilled and motivated Senior Research Associate to join the Diagnostic Assay Development team. The SRA will be a key contributor, executing the technical development, optimization, and rigorous testing of novel Laboratory Developed Tests (LDTs) in a dynamic, high-growth environment. This role, reporting to the Sr. Manager, Diagnostic Assay Development, requires extensive hands-on experience in advanced molecular biology techniques and a dedication to high-quality data generation in support of ambitious product development goals.

Job Responsibility

  • Hands-on execution of complex single-cell and spatial genomics assays (e.g., sample processing, library preparation, sequencing)
  • Systematically troubleshoot, optimize, and refine specific steps within the assay workflow to improve performance, robustness, and efficiency
  • Perform feasibility studies on new reagents, instrumentation, and process improvements for clinical readiness
  • Prepare and process samples in support of large-scale clinical research studies
  • Generate and maintain meticulous laboratory records, protocols (SOPs), and batch records following Good Documentation Practices (GDP)
  • Execute formal experiments for analytical validation studies, including assessment of accuracy, precision, limit of detection, and reproducibility
  • Ensure all work is conducted under appropriate quality controls
  • Present experimental data clearly and concisely in team meetings and written reports
  • Support the transfer of robust assay workflows to the CLIA operations team
  • Collaborate closely with R&D Scientists, Automation Engineers, and Bioinformatics teams to meet project milestones
  • Work closely with the internal lab operations team to support the maintenance of a high-quality, organized laboratory environment, including inventory management and forecasting, equipment calibration, and ensuring compliance with safety standards

Requirements

  • B.S. or M.S. in Molecular Biology, Genetics, Biochemistry, or a related scientific field
  • B.S. with 5+ years or M.S. with 3+ years of hands-on experience in molecular diagnostics or genomics assay development in an industry setting
  • Direct, demonstrable experience with advanced molecular technologies, particularly Next-Generation Sequencing (NGS) workflows
  • Exceptional proficiency in molecular biology techniques, including nucleic acid extraction, PCR/qPCR, and NGS library preparation
  • A proven track-record of using and optimizing and troubleshooting molecular biology protocols
  • Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples)
  • Experience working within a quality system or environment governed by CLIA, CAP, or ISO 13485 standards strongly preferred
  • Prior hands-on experience with 10x Genomics single-cell or spatial technologies (e.g., Chromium or Xenium platforms) is a strong advantage
  • Experience with automated liquid handling for high-throughput assay execution is a strong advantage
  • experience with microscopy techniques a plus

Nice to have

  • Experience working within a quality system or environment governed by CLIA, CAP, or ISO 13485 standards
  • Prior hands-on experience with 10x Genomics single-cell or spatial technologies (e.g., Chromium or Xenium platforms)
  • Experience with automated liquid handling for high-throughput assay execution
  • Experience with microscopy techniques

What we offer

  • Equity grants
  • Comprehensive health and retirement benefit programs
  • Annual bonus program or sales incentive program
  • Health Package
  • Easy-to-use Benefits
  • Family oriented
  • Generous Time Off

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