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10x Genomics is establishing a diagnostics effort, translating our leading single cell and spatial assay technologies into impactful clinical applications. We are seeking a highly skilled and motivated Senior Research Associate to join the Diagnostic Assay Development team. The SRA will be a key contributor, executing the technical development, optimization, and rigorous testing of novel Laboratory Developed Tests (LDTs) in a dynamic, high-growth environment. This role, reporting to the Sr. Manager, Diagnostic Assay Development, requires extensive hands-on experience in advanced molecular biology techniques and a dedication to high-quality data generation in support of ambitious product development goals.
Job Responsibility
Hands-on execution of complex single-cell and spatial genomics assays (e.g., sample processing, library preparation, sequencing)
Systematically troubleshoot, optimize, and refine specific steps within the assay workflow to improve performance, robustness, and efficiency
Perform feasibility studies on new reagents, instrumentation, and process improvements for clinical readiness
Prepare and process samples in support of large-scale clinical research studies
Generate and maintain meticulous laboratory records, protocols (SOPs), and batch records following Good Documentation Practices (GDP)
Execute formal experiments for analytical validation studies, including assessment of accuracy, precision, limit of detection, and reproducibility
Ensure all work is conducted under appropriate quality controls
Present experimental data clearly and concisely in team meetings and written reports
Support the transfer of robust assay workflows to the CLIA operations team
Collaborate closely with R&D Scientists, Automation Engineers, and Bioinformatics teams to meet project milestones
Work closely with the internal lab operations team to support the maintenance of a high-quality, organized laboratory environment, including inventory management and forecasting, equipment calibration, and ensuring compliance with safety standards
Requirements
B.S. or M.S. in Molecular Biology, Genetics, Biochemistry, or a related scientific field
B.S. with 5+ years or M.S. with 3+ years of hands-on experience in molecular diagnostics or genomics assay development in an industry setting