CrawlJobs Logo
Amgen Logo Amgen · Research and Development

Senior Principal Scientist – Target Discovery & Biology

United States, Thousand Oaks 171106.00 - 209556.00 USD / Year · Job Posted December 18, 2025
Apply Position
Job Link Share

Job Description

Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi-omics profiling, human genetics, and complex in vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution. We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in vitro models that help power target discovery and functional genomics efforts.

Job Responsibility

  • Provide scientific and operational leadership for a team of scientists delivering advanced in vitro models and screening-ready systems in collaboration with therapeutic area partners
  • Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data
  • Champion partnerships with automation colleagues accelerate model deployment and reproducibility
  • Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights
  • Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms
  • Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline

Requirements

  • Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience
  • Master’s degree and 6 years of directly related experience
  • Bachelor’s degree and 8 years of directly related experience
  • Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline
  • 6+ years of relevant experience in biotech or pharma, including leadership of scientific teams
  • Strong track record in complex in vitro model development, cell engineering, and high-throughput or automated screening
  • Experience with high-content imaging and transcriptional assay readouts
  • Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
  • Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation
  • Experience in leading or mentoring scientists, with proven success in project execution and team development
  • Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
  • Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment

What we offer

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
Amgen - All Job Offers

Looking for more opportunities?

Search for other job offers that match your skills and interests.

Suggested Tags: Frontend Developer Secretary Talent Manager Salesforce Administrator Data Analyst
Similar Jobs for

Senior Principal Scientist – Target Discovery & Biology

8 matching positions

Senior Principal Scientist – Chemical Biology & Proximity-Based Therapeutics

Amgen’s Induced Proximity Platform (IPP) is advancing a growing portfolio of the...
Location
Location
United States , Thousand Oaks
Salary
Salary:
162509.80 - 219866.20 USD / Year
amgen.com Logo
Amgen
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Doctorate degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 3 years chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas experience
  • Master's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 6 years of chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas experience
  • Bachelor's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 8 years of chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas experience
Job Responsibility
Job Responsibility
  • Lead discovery efforts using phenotypic screening and chemical genetics approaches to identify novel proximity-driven mechanisms
  • Develop and apply disease-relevant cellular models to uncover actionable biology
  • Integrate chemical biology and mechanistic studies to translate phenotypic findings into drug discovery programs
  • Contribute to a growing portfolio of induced proximity-based therapeutic opportunities
  • Design and implement phenotypic screening strategies to enable discovery of molecular glues and proximity-based modulators
  • Build and optimize high-content and high-throughput assays, including imaging-based and multi-parametric readouts
  • Apply chemical genetics approaches to interrogate biological pathways and support target identification and validation
  • Integrate chemical biology and mechanistic studies to elucidate compound mode of action, including induced proximity and protein interaction networks
  • Partner with cross-functional teams to advance discoveries from screening through early drug discovery
  • Leverage omics, and data-driven approaches to extract insights from complex phenotypic datasets
What we offer
What we offer
  • Retirement and Savings Plan with generous company contributions
  • Group medical, dental and vision coverage
  • Life and disability insurance
  • Flexible spending accounts
  • Discretionary annual bonus program
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
  • Fulltime
Read More
Arrow Right
New

Supervisor

An exciting opportunity has arisen for a talented Supervisor to join our Rushden...
Location
Location
United Kingdom , Rushden
Salary
Salary:
31450.00 GBP / Year
sportsdirect.com Logo
Sports Direct
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Minimum 1+ year experience in premium or luxury fashion retail, ideally in a supervisory or management-related role
  • Proven ability to support, motivate, and guide team members in a fast-paced retail environment
  • Strong track record of achieving sales targets and delivering results
  • Good product knowledge, including brands, fashion trends, and materials
  • Understanding of retail operations, including merchandising, stock control, and loss prevention
  • Strong verbal and written communication skills, with the ability to build positive working relationships
Job Responsibility
Job Responsibility
  • Support in driving the commercial success of the store and drive store performance
  • Identify key opportunities to enhance performance in line with current trends
  • Support the store leadership team in the implementation of strategic plans to achieve departmental goals and objectives
  • Analyse data and key performance indicators to make informed commercial decisions and drive KPIs
  • Be responsible for your department and team's performance
  • Lead and inspire your store team, providing guidance, coaching, and support
  • Work closely with your Store Management team, acting on feedback and working towards targets and deadlines
  • Build lasting relationships with internal and external stakeholders
  • Display exemplary communication and interpersonal skills
  • Support in driving the team's personal development and progression
What we offer
What we offer
  • 28 days holiday a year, inclusive of bank holidays
  • 20% Staff Discount across all Frasers Group Stores
  • 50% in store uniform discount
  • Weekly/Monthly & Quarterly Commercial Bonuses
  • Commission-led bonuses across a wide range of products
  • Long Service awards
  • Discounted Gym membership
  • Excellent career development opportunities
  • Cycle to work scheme
  • Wide range of Development Courses with National Qualifications
  • Fulltime
Read More
Arrow Right
New

Part Time Sales Assistant

Location
Location
Ireland , Dublin
Salary
Salary:
Not provided
sportsdirect.com Logo
Sports Direct
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Retail or customer service experience is a plus, but not essential
  • Confident communicator with a friendly, positive attitude
  • Team player who thrives in a fast-paced environment
  • Flexible and reliable, especially during peak trade periods
  • Motivated to deliver results and take pride in your work
Job Responsibility
Job Responsibility
  • Greet customers and assist with product selection and queries
  • Deliver outstanding customer service at all touchpoints
  • Maintain well-stocked, tidy, and visually appealing shop floor areas
  • Replenish shelves and rails to meet customer demand
  • Process transactions efficiently and accurately at the till
  • Promote current offers and upsell where appropriate
  • Work collaboratively to achieve daily sales and service goals
What we offer
What we offer
  • Competitive Hourly Rate
  • Flexible Working to suit your availability
  • Staff Discount across all Frasers Group brands
  • Career Progression in a fast-growing retail environment
  • Fun, Fast-Paced Atmosphere with a supportive team culture
  • Parttime
Read More
Arrow Right
New

Casual Sales Assistant

This is retail with momentum. As a Sales Assistant at Sports Direct, you're on t...
Location
Location
United Kingdom , Barnsley
Salary
Salary:
Not provided
sportsdirect.com Logo
Sports Direct
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • A confident, friendly, positive attitude
  • Retail or customer service experience is a bonus, but not essential
  • Motivation to deliver results and take real pride in your work
  • Flexibility and reliability, especially through peak trade
  • A team-player mentality that thrives when the pace picks up
  • Strong communication skills and a customer-first mindset
Job Responsibility
Job Responsibility
  • Greet customers, answer questions, and help them find the right product
  • Deliver brilliant service at every touchpoint, from the door to the till
  • Keep the shop floor tidy, well-stocked, and visually on point
  • Replenish shelves and rails so the floor is always ready for the next customer
  • Process transactions quickly and accurately
  • Promote current offers and spot smart upsell opportunities
  • Work as one team to hit daily sales and service goals
What we offer
What we offer
  • Competitive hourly rate that rewards what you put in
  • Flexible working to fit around your life
  • Staff discount across the full Frasers Group family of brands
  • Career progression in a fast-growing retail business that promotes from within
  • A fun, fast-paced atmosphere with a team that has your back
  • Parttime
Read More
Arrow Right
New

Hotel Cleanliness Expert

Our jobs aren’t just about giving guests a clean room and a freshly made bed. In...
Location
Location
Vietnam , Nha Trang
Salary
Salary:
Not provided
https://www.marriott.com Logo
Marriott Bonvoy
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Ensuring a safe work place
  • following company policies and procedures
  • maintaining confidentiality
  • upholding quality standards
  • ensuring your uniform, personal appearance, and communications are professional
  • ability to stand, sit, or walk for an extended time
  • ability to move, lift, carry, push, pull, and place objects weighing less than or equal to 50 pounds without assistance
Job Responsibility
Job Responsibility
  • Giving guests a clean room and a freshly made bed
  • building an experience that is memorable and unique
  • maintaining the appearance and cleanliness of the whole hotel
  • delivering guest requests
  • stocking carts
  • cleaning rooms and public spaces
  • Fulltime
Read More
Arrow Right
New

Collections Agent Spanish & English Speaker

Are you a results-oriented professional with a knack for negotiation? Do you wan...
Location
Location
Portugal , Porto, Lisboa
Salary
Salary:
Not provided
https://www.randstad.com Logo
Randstad
Expiration Date
June 17, 2026
Flip Icon
Requirements
Requirements
  • Fluency in both Spanish (C1) and English (C1), both spoken and written (mandatory)
  • 2+ years of experience in collections or credit control, preferably managing Key Accounts & Agencies within the Digital sector (mandatory)
  • Proven ability to manage B2B collection cycles, handle sensitive financial matters, and engage in professional negotiation
  • Familiarity with debt collection tools, CRM systems, and reporting platforms
  • Strong organizational, problem-solving, and communication skills with a high attention to detail
  • Sound business judgment and the ability to influence others while maintaining a customer-centric approach
  • Ability to work independently as well as part of a cross-functional team
Job Responsibility
Job Responsibility
  • Manage outstanding receivables from key accounts and agencies
  • Handle customer interactions via email, voice, and video calls
  • Follow strict SOPs and service quality protocols
  • Proactive outreach to customers regarding overdue balances
  • Oversee the entire dunning process
  • Build and maintain strong customer relationships
  • Investigate and resolve payment disputes by collaborating with internal stakeholders
  • Maintain accurate records of customer contacts and billing information
  • Ensure efficient collection processes to reduce credit risk and minimize profit loss
  • Fulltime
Read More
Arrow Right
New

Buyer Registration Agent - French Speaker

Ready to drive your career in the fast-paced world of automotive commerce? We ar...
Location
Location
Portugal , Lisbon
Salary
Salary:
Not provided
https://www.randstad.com Logo
Randstad
Expiration Date
June 11, 2026
Flip Icon
Requirements
Requirements
  • Experience in customer relations is mandatory
  • Fluent in French (C2 or native) and English (C1)
Job Responsibility
Job Responsibility
  • Customer Registration: Review and validate customer documents during registration, ensuring compliance with strict requirements, and accurately inputting data into Salesforce (SF)
  • Account Access Management: Grant appropriate login credentials to customers based on completed registration requirements
  • Database Maintenance: Keep customer accounts up to date by accurately recording all modifications across relevant systems
  • Fulltime
Read More
Arrow Right
New

Customer Support

Are new technologies part of your everyday life? Are you the support technician ...
Location
Location
Portugal , Lisboa
Salary
Salary:
Not provided
https://www.randstad.com Logo
Randstad
Expiration Date
June 18, 2026
Flip Icon
Requirements
Requirements
  • Fluency in both German and English, spoken and written
  • preferably previous working experience in a call center
  • high school diploma or a higher education degree
  • experience in technical Troubleshooting (preferable)
Job Responsibility
Job Responsibility
  • Assist users with Pre-Sales, General Inquiries, and technical support issues via phone/email/chat/social messaging channels
  • adapt the brand’s voice and tone for interactions on both private and public channels
  • respond appropriately to customer escalations and escalate issues to higher tiers of support as defined
  • document relevant case information
Read More
Arrow Right