Senior Principal Scientist – Target Discovery & Biology Job at Amgen (Thousand Oaks)

Senior Principal Scientist – Target Discovery & Biology

Amgen

Location:
United States , Thousand Oaks

Category:
Research and Development

Contract Type:
Not provided

Salary:

171106.00 - 209556.00 USD / Year

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Job Description:

Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi-omics profiling, human genetics, and complex in vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution. We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in vitro models that help power target discovery and functional genomics efforts.

Job Responsibility:

Provide scientific and operational leadership for a team of scientists delivering advanced in vitro models and screening-ready systems in collaboration with therapeutic area partners
Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data
Champion partnerships with automation colleagues accelerate model deployment and reproducibility
Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights
Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms
Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline

Requirements:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience
Master’s degree and 6 years of directly related experience
Bachelor’s degree and 8 years of directly related experience
Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline
6+ years of relevant experience in biotech or pharma, including leadership of scientific teams
Strong track record in complex in vitro model development, cell engineering, and high-throughput or automated screening
Experience with high-content imaging and transcriptional assay readouts
Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation
Experience in leading or mentoring scientists, with proven success in project execution and team development
Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment

What we offer:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible