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Amgen Logo Amgen · Research and Development

Senior Principal Scientist – Target Discovery & Biology

United States, Thousand Oaks 171106.00 - 209556.00 USD / Year · Job Posted December 18, 2025
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Job Description

Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi-omics profiling, human genetics, and complex in vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution. We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in vitro models that help power target discovery and functional genomics efforts.

Job Responsibility

  • Provide scientific and operational leadership for a team of scientists delivering advanced in vitro models and screening-ready systems in collaboration with therapeutic area partners
  • Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data
  • Champion partnerships with automation colleagues accelerate model deployment and reproducibility
  • Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights
  • Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms
  • Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline

Requirements

  • Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience
  • Master’s degree and 6 years of directly related experience
  • Bachelor’s degree and 8 years of directly related experience
  • Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline
  • 6+ years of relevant experience in biotech or pharma, including leadership of scientific teams
  • Strong track record in complex in vitro model development, cell engineering, and high-throughput or automated screening
  • Experience with high-content imaging and transcriptional assay readouts
  • Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
  • Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation
  • Experience in leading or mentoring scientists, with proven success in project execution and team development
  • Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
  • Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment

What we offer

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
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