CrawlJobs Logo
Amgen Logo Amgen · Research and Development

Senior Principal Scientist – Chemical Biology & Proximity-Based Therapeutics

United States, Thousand Oaks Employment contract 162509.80 - 219866.20 USD / Year · Job Posted May 04, 2026
Apply Position
Job Link Share

Job Description

Amgen’s Induced Proximity Platform (IPP) is advancing a growing portfolio of therapeutic opportunities that leverage proximity biology to access previously undruggable targets. Through the discovery of small molecules that induce or stabilize protein–protein interactions, IPP is expanding the range of mechanisms and targets addressable by drug discovery. We are seeking an exceptional Senior Principal Scientist to lead discovery efforts at the intersection of chemical biology, induced proximity, and phenotypic drug discovery. This role will focus on molecular glue discovery in disease-relevant systems, combining phenotypic screening, chemical genetics, and mechanistic biology to uncover novel therapeutic opportunities.

Job Responsibility

  • Lead discovery efforts using phenotypic screening and chemical genetics approaches to identify novel proximity-driven mechanisms
  • Develop and apply disease-relevant cellular models to uncover actionable biology
  • Integrate chemical biology and mechanistic studies to translate phenotypic findings into drug discovery programs
  • Contribute to a growing portfolio of induced proximity-based therapeutic opportunities
  • Design and implement phenotypic screening strategies to enable discovery of molecular glues and proximity-based modulators
  • Build and optimize high-content and high-throughput assays, including imaging-based and multi-parametric readouts
  • Apply chemical genetics approaches to interrogate biological pathways and support target identification and validation
  • Integrate chemical biology and mechanistic studies to elucidate compound mode of action, including induced proximity and protein interaction networks
  • Partner with cross-functional teams to advance discoveries from screening through early drug discovery
  • Leverage omics, and data-driven approaches to extract insights from complex phenotypic datasets
  • Contribute to scientific strategy, present findings, and mentor team members as appropriate

Requirements

  • Doctorate degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 3 years chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas experience
  • Master's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 6 years of chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas experience
  • Bachelor's degree in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field and 8 years of chemical biology and small molecule discovery, with experience in proximity-based mechanisms, molecular glues, or related areas experience

Nice to have

  • Demonstrated experience developing and executing phenotypic screening assays, including high-content or high-throughput platforms
  • Experience working with disease-relevant cellular models
  • Strong background in mechanism-of-action studies using cellular and molecular biology approaches
  • Proven ability to integrate biology and chemistry to drive discovery efforts
  • Track record of scientific contributions (publications, patents, presentations)
  • Excellent collaboration and communication skills in a matrixed research environment
  • Experience with chemical genetics approaches in phenotypic discovery
  • Familiarity with proteomics, transcriptomics, or systems biology approaches
  • Experience supporting target identification or deconvolution from phenotypic screens
  • Exposure to induced proximity or targeted protein degradation concepts
  • Experience contributing to or leading cross-functional discovery teams

What we offer

  • Retirement and Savings Plan with generous company contributions
  • Group medical, dental and vision coverage
  • Life and disability insurance
  • Flexible spending accounts
  • Discretionary annual bonus program
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
Amgen - All Job Offers

Looking for more opportunities?

Search for other job offers that match your skills and interests.

Suggested Tags: Frontend Developer Secretary Talent Manager Salesforce Administrator Data Analyst
Similar Jobs for

Senior Principal Scientist – Chemical Biology & Proximity-Based Therapeutics

8 matching positions

Mobile Associate - Retail Sales

This role supports retail operations by engaging customers and facilitating thei...
Location
Location
United States , Irvine
Salary
Salary:
19.50 - 24.50 USD / Hour
https://www.t-mobile.com Logo
T-Mobile
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • High School Diploma/GED (Required)
  • 6 months of customer service and/or sales experience, Retail environment. (Preferred)
  • Passionate customer advocate with the desire to be yourself when connecting and having fun doing it! (Required)
  • Competitive drive and proven ability to succeed in a fast-paced sales environment. (Required)
  • Willingness to work alongside peers and store leaders, learning and sharing ideas, while serving customers and providing resolutions to issues. (Required)
  • Effective at balancing customer needs and performance goals. (Required)
  • At least 18 years of age
  • Legally authorized to work in the United States
Job Responsibility
Job Responsibility
  • Develop proficiency in customer service and sales to deliver personalized technology and service solutions that meet individual needs
  • Utilize digital tools to demonstrate network coverage, service plans, and product features to enhance customer understanding and engagement
  • Complete required training to build knowledge of retail processes, systems, and wireless technology innovations
  • Collaborate with colleagues across channels to support a seamless customer experience and contribute to team initiatives
  • Also responsible for other duties/projects as assigned by business management as needed
What we offer
What we offer
  • Annual stock grant
  • employee stock purchase plan
  • 401(k)
  • free, year-round money coaches
  • medical, dental and vision insurance
  • flexible spending account
  • paid time off and up to 12 paid holidays
  • paid parental and family leave
  • family building benefits
  • back-up care
  • Parttime
Read More
Arrow Right

Ward Hostess/Host

Are you looking for a new challenge? Do you have a passion for customer service?...
Location
Location
United Kingdom , Enfield
Salary
Salary:
12.71 GBP / Hour
14forty.co.uk Logo
14forty
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Awareness of food & hygiene standards
  • Passionate about patient care, with the ability to communicate effectively with patients, visitors and healthcare staff
  • Able to work under pressure, individually and as part of a team with a flexible approach to meet the needs of the business
  • Confident working in a hospital environment and aware at times you will come in contact with patients that are particularly unwell or showing signs of distress
  • Taking pride in what you do and a willingness to learn and go the extra mile for our patients
  • This position is subject to a Disclosure & Barring Service check
  • costs met by the employer
Job Responsibility
Job Responsibility
  • Provide menus, take orders from patients and support with all dietary and allergen queries
  • Prepare and deliver all refreshments and meals for breakfast, lunch and dinner service
  • Clear down ward areas and wash up dirty dishes ensuring that the kitchen is fully prepared for next service
  • Liaise with ward staff to ensure patients' needs are met in a timely manner
  • Offer a great customer service by always putting the patient first
What we offer
What we offer
  • Competitive pay
  • great perks
  • unrivalled opportunities for learning and development
  • Parttime
Read More
Arrow Right

Marketing Manager for Pharmacy, Healthcare & Seasonal

Accountable for shaping and delivering the full marketing agenda across our most...
Location
Location
Ireland , Dublin, City West
Salary
Salary:
Not provided
boots.com Logo
Boots
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • In depth, cross channel marketing expertise for a retailer
  • A strong understanding of customer behaviour and ability to understand data, insights and customer journeys
  • An analytical approach to marketing, balancing brand and commercial objectives
  • Demonstratable commercial and strategic knowledge, allowing you to execute successful multichannel campaigns across multiple channels simultaneously
  • Experience or knowledge of the Irish retail and healthcare market
  • Financial literacy and budget management
  • Confidence in presenting and discussing activity with large groups, in person and remotely
  • Stakeholder management experience at all seniority levels and strong relationship building and maintenance skills
  • Ability to manage simultaneous activity across multiple business areas
  • A flexible and proactive approach to the role
Job Responsibility
Job Responsibility
  • Development and delivery of full, cross-category marketing plan
  • Assessment of healthcare commercial calendar and opportunities working to maximise impact across these areas
  • Align with ROI Pharmacy team on business priorities, service and proposition development, ensuring best in class customer-first comms messaging
  • Continually review of needs of ROI business and creation of bespoke localised campaigns
  • Collaboration with ROI commercial teams to understand which priorities and initiatives should be supported throughout the year and maintain excellent relationships of same
  • Collaboration with Boots UK teams to understand and adapt wider business activity where relevant
  • Partner with the incumbent media, PR and creative agencies to bring all campaign components together, pushing for opportunities to diversify, strengthen and optimise plans throughout
  • Drive reporting and post campaign analysis, sharing this with the wider business as required
  • Partner with Boots UK ISM team, to agree and deliver all sales plan activity, development and messaging – including print and digital screen content
  • Collaborate with legal/ regulatory affairs to ensure all activity is in line with the needs of the Irish market and that we are compliant with local laws and regulations across all areas
What we offer
What we offer
  • Generous Employee Discount
  • Enhanced Leave Entitlements
  • Company Pension
  • Access to a range of learning and development resources and programmes
  • Fulltime
Read More
Arrow Right

Assistant Accountant (12 month FTC)

Citadel Source is partnering with a growing organisation in the East Bristol are...
Location
Location
United Kingdom , Bristol
Salary
Salary:
26000.00 - 28000.00 GBP / Year
citadelsource.com Logo
Citadel Source
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • proactive
  • reliable
  • strong sense of responsibility
  • solid work ethic
  • strong communication skills
  • positive attitude
  • ability to work effectively with others
Job Responsibility
Job Responsibility
  • Support the production of management accounts
  • Monthly balance sheet reconciliations
  • Preparation of balance sheet reconciliations for each period
  • Support the analysis of the management accounts
  • Preparation of accruals and prepayments
  • Posting journals
What we offer
What we offer
  • Hybrid working policy (2 days per week for the right candidate)
  • Parking on site
  • Fulltime
Read More
Arrow Right

Ward Hostess/Host

A new opportunity has arisen for a Ward Hostess/Host to join the Medirest Family...
Location
Location
United Kingdom , Great Missenden
Salary
Salary:
12.71 GBP / Hour
14forty.co.uk Logo
14forty
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Awareness of food & hygiene standards
  • Passionate about patient care, with the ability to communicate effectively with patients, visitors and healthcare staff
  • Able to work under pressure, individually and as part of a team with a flexible approach to meet the needs of the business
  • Confident working in a hospital environment and aware at times you will come in contact with patients that are particularly unwell or showing signs of distress
  • Taking pride in what you do and a willingness to learn and go the extra mile for our patients
  • This position is subject to a Disclosure & Barring Service check
  • costs met by the employer
Job Responsibility
Job Responsibility
  • Provide menus, take orders from patients and support with all dietary and allergen queries
  • Prepare and deliver all refreshments and meals for breakfast, lunch and dinner service
  • Clear down ward areas and wash up dirty dishes ensuring that the kitchen is fully prepared for next service
  • Liaise with ward staff to ensure patients' needs are met in a timely manner
  • Offer a great customer service by always putting the patient first
What we offer
What we offer
  • Competitive pay
  • Great perks
  • Unrivalled opportunities for learning and development
  • Parttime
Read More
Arrow Right

Mobile Associate - Retail Sales

This role supports retail operations by engaging customers and facilitating thei...
Location
Location
United States , Galesburg
Salary
Salary:
18.00 - 23.00 USD / Hour
https://www.t-mobile.com Logo
T-Mobile
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • High School Diploma/GED (Required)
  • 6 months of customer service and/or sales experience, Retail environment (Preferred)
  • Passionate customer advocate with the desire to be yourself when connecting and having fun doing it! (Required)
  • Competitive drive and proven ability to succeed in a fast-paced sales environment. (Required)
  • Willingness to work alongside peers and store leaders, learning and sharing ideas, while serving customers and providing resolutions to issues. (Required)
  • Effective at balancing customer needs and performance goals. (Required)
  • At least 18 years of age
  • Legally authorized to work in the United States
Job Responsibility
Job Responsibility
  • Develop proficiency in customer service and sales to deliver personalized technology and service solutions that meet individual needs
  • Utilize digital tools to demonstrate network coverage, service plans, and product features to enhance customer understanding and engagement
  • Complete required training to build knowledge of retail processes, systems, and wireless technology innovations
  • Collaborate with colleagues across channels to support a seamless customer experience and contribute to team initiatives
  • Also responsible for other duties/projects as assigned by business management as needed
What we offer
What we offer
  • Annual stock grant
  • employee stock purchase plan
  • 401(k)
  • access to free, year-round money coaches
  • medical insurance
  • dental insurance
  • vision insurance
  • flexible spending account
  • paid time off
  • up to 12 paid holidays
  • Parttime
Read More
Arrow Right

Client Organization - Managers Control Self-Assessment (MCA) Senior Analyst

The Client Organization promotes a unified, enterprise-wide client focus through...
Location
Location
United Kingdom , Belfast
Salary
Salary:
Not provided
https://www.citi.com/ Logo
Citi
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Extensive years of experience in operational risk management, compliance, audit, or other control-related functions in the financial services industry
  • Ability to identify, measure, and manage key risks and controls
  • Strong knowledge in the development and execution for controls
  • Proven experience in control related functions in the financial industry
  • Proven experience in implementing sustainable solutions and improving processes
  • Understanding of compliance laws, rules, regulations, and best practices
  • Understanding of Citi's Policies, Standards, and Procedures
  • Strong analytical skills to evaluate complex risk and control activities and processes
  • Strong verbal and written communication skills, with a demonstrated ability to engage at the senior management level
  • Strong problem-solving and decision-making skills
Job Responsibility
Job Responsibility
  • Help execute control activities in support of Managers Control Self-Assessment (MCA) program, also known as Risk & Control Self-Assessment (RCSA)
  • Assist in the MCA program, including the annual/semiannual/quarterly/monthly attestation, quality oversight, and related reporting
  • Help identify, analyze, and assess potential risks, ensuring timely identification and remediation of significant control issues and operational events
  • Execute MCA in accordance with the ORM Policy & Framework, as well as applicable Policies, Standards, and Procedures
  • Assist to develop and maintain ORM tools and methodologies to support accurate and consistent assessments of the risk and control environment
  • Help provide recommendations to enhances or improve the MCA
  • Support the MCA tracking and reporting inventory
  • Continue to help drive MCA best practices, transformation, and execution consistency across business/functions
  • Appropriately assess risk when business decisions are made
What we offer
What we offer
  • Generous holiday allowance starting at 27 days plus bank holidays
  • increasing with tenure
  • A discretional annual performance related bonus
  • Private medical insurance packages to suit your personal circumstances
  • Employee Assistance Program
  • Pension Plan
  • Paid Parental Leave
  • Special discounts for employees, family, and friends
  • Access to an array of learning and development resources
  • Fulltime
Read More
Arrow Right

Bar Supervisor - NOBU Bangkok

Bar Supervisor - NOBU Bangkok at Empire Tower Restaurants. A full-time position ...
Location
Location
Thailand , Bangkok
Salary
Salary:
Not provided
https://www.marriott.com Logo
Marriott Bonvoy
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • High school diploma or G.E.D. equivalent
  • At least 2 years of related work experience
  • At least 2 years of supervisory experience
Job Responsibility
Job Responsibility
  • Inspect grooming and attire of staff, and rectify any deficiencies
  • Communicate with guests, other employees, and/or departments to ensure guest needs are met
  • Ensure staff is working together as a team
  • Monitor dining rooms for seating availability, service, safety, and well being of guests
  • Complete work orders for maintenance repairs
  • Complete scheduled inventories of supplies, food, and liquor
  • Check stock and requisition necessary supplies
  • Obtain assigned bank and ensure accuracy of contracted monies, obtaining change required for expected business level, and keeping bank secure at all times
  • Communicate last call at designated closing time
  • Assist management in hiring, training, scheduling, evaluating, counseling, disciplining, and motivating and coaching employees
  • Fulltime
Read More
Arrow Right