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Senior NGS Bioinformatician

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SOPHiA GENETICS

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Location:
Switzerland; United States , Rolle ▼

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Category:
IT - Software Development

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Contract Type:
Not provided

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Salary:

71250.00 - 143750.00 USD / Year
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Job Description:

Enable us to make a positive impact on the outcomes for cancer and rare disease patients worldwide. Role will span the full lifecycle of bioinformatics product development - from exploratory research and feasibility studies to analytical validation and IVD/CDx development under regulated frameworks. Operate in two complementary modes: Research & Innovation and Product & Regulatory Development.

Job Responsibility:

  • Design and execute analytical and exploratory studies across diverse NGS datasets
  • Evaluate and improve algorithmic performance across variant classes and technologies
  • Explore emerging sequencing technologies and bioinformatics methods
  • Conduct deep-dive analyses to generate biological insights from complex datasets
  • Design and statistically analyze analytical validation studies (sensitivity, specificity, precision, accuracy, LoD, LoB)
  • Contribute to performance evaluation documentation supporting IVD/CDx development
  • Contribute code to production-grade NGS pipelines, ensuring robustness, reproducibility, and performance
  • Contribute to scientific publications, white papers, or conference presentations
  • Contribute to projects with external collaborators, including project planning, data analysis and results presentation

Requirements:

  • PhD in Bioinformatics / Computational Biology (or equivalent industry experience)
  • 5+ years of experience in NGS data analysis in academic, biotech, or diagnostics environments
  • Experience analyzing somatic variants (SNVs, indels, CNVs, fusions) in oncology NGS assays
  • Experience with targeted panel sequencing and/or hybrid capture technologies
  • Strong proficiency in Python and/or R for statistical analysis and data exploration
  • Excellent communication & presentation skills (English is a must, any other language is an asset)

Nice to have:

  • Hematologic cancer biology
  • RNA/transcriptomic analysis
  • In vitro diagnostic development
  • Analytical performance study design and statistical analyses
  • Experience working with workflow management systems (e.g., Nextflow or similar)
What we offer:
  • Sickness and Accident coverage through Helsana
  • Meal Vouchers at 90CHF PM with our partner cafeteria
  • A fun and engaging work environment, with Rest & Entertainment space, full stocked free coffee machine and free fruit
  • Free parking in an easy to access location
  • A strong social committee whose purpose is to make SOPHiA GENETICs both enjoyable as well as rewarding
  • Direct interaction and exposure to senior leadership and our executive team locally

Additional Information:

Job Posted:
March 27, 2026

Employment Type:
Fulltime
Work Type:
Hybrid work
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