Senior Manufacturing Systems Engineer Job at Amgen (Holly Springs)

Senior Manufacturing Systems Engineer

Be part of Amgen's newest and most advanced drug substance manufacturing plant. ...

Location

United States , Holly Springs

Salary:

147421.00 - 177467.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

High School Diploma / GED and 10 years of Engineering experience
Associate’s Degree and 8 years of Engineering experience
Bachelor’s Degree and 4 years of Engineering experience
Master’s Degree and 2 years of Engineering experience
Doctorate Degree
Degree in Electrical Engineering or Computer Science, Chemical Engineering or Biotech Engineering
Direct knowledge of BAS design, experience in building control engineering and troubleshooting with GMP biopharmaceutical production facility and utility equipment/systems automation and integrating various OEM automation software
Extensive understanding and background in programming, design, installation and lifecycle management of building automation controls, PLC and field device/instrumentation technologies
Experience with Siemens Building Automation system, Rockwell industrial automation hardware and systems, ability to perform sophisticated troubleshooting activities with Amgen DTI, System Integration using OPC, Foundation Fieldbus, Profibus, and DeviceNet technologies
Ability to interpret and apply GAMPs and GMPs and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88, and S95

Job Responsibility

Provide automation technical leadership to a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP Drug Substance Plant Operations
Work hand in hand with the capital project team to deliver robust automation systems to operate the new plant
Maintain the Building Automation System (BAS)on Siemens Desigo CC
Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions
Collaborate with business partners to understand how utility and building equipment systems automation can improve workflow and productivity
Synthesize requirements from clients, customers or end-users to develop the best automation solutions
Provide clear documentation for delivered solutions and processes
work closely with QA partners while supporting computerized systems validation processes in a GxP environment
Maintain Data Integrity Assessments with the current Amgen and Industry standards
Maintain detailed specification and engineering policies and procedures that affect multiple organizational units

What we offer

Competitive and comprehensive Total Rewards Plans that are aligned with local industry standards

Fulltime

Senior Manufacturing Systems Engineer: Automation

HOW MIGHT YOU DEFY IMAGINATION? If you feel like you're part of something bigger...

Location

United States , Holly Springs

Salary:

Not provided

Amgen

Expiration Date

Until further notice

Requirements

Basic Qualifications: High School Diploma / GED and 10 years of Engineering experience OR Associate's Degree and 8 years of Engineering experience OR Bachelor's Degree and 4 years of Engineering experience OR Master's Degree and 2 years of Engineering experience OR Doctorate Degree
Preferred Qualifications: Degree in Electrical Engineering, Computer Science, Chemical Engineering, Biotech Engineering, or related field
Direct knowledge of Automation System design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation such as media, harvest, bioreactors, solution prep, single use mixing vessels, chromatography, TFFL/TFFX, viral filtration, viral inactivation, UF/DF, depth filtration, drug substance fill, CIP/SIP, clean utilities, and integrating various OEM automation software
Extensive understanding and background in programming, design, installation and lifecycle management of manufacturing process controls, automation and field instrumentation technologies
Experience with Emerson DeltaV DCS system, Process Control Network design including network segregation, virtual infrastructure design and implementation, and ability to perform advanced troubleshooting activities, system integration using OPC, Foundation Fieldbus, Profibus, and DeviceNet technologies. Experience with DeltaV Live is preferred
Ability to interpret and apply GAMPs and GMPs and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88, and S95
Experience in Capital Project Lifecycle Management: Conceptual Design, Scope and cost estimate development, business case development, detailed design, engineering and validation documentation and project execution
Demonstrated hands-on experience in developing process control strategies for New Product Introduction and New Technology Deployment for Drug Substance Plant Operations
Demonstrated experience with continuous improvements resulting in enhanced safety, system reliability, and productivity (e.g. cycle times, and reduced plant utilities usage etc.) related to Drug Substance Plant Operations
The ideal individual must be a self-directed team player ready to mentor and develop engineering staff and embrace a team-based culture that relies on collaboration for effective decision-making

Job Responsibility

Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS)
Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions
Collaborate with business partners to understand how automation can improve workflow and productivity
Synthesize requirements from clients, customers or end-users to develop the best automation solutions
Provide clear documentation for delivered solutions and processes
work closely with QA partners while supporting computerized systems validation processes in a GxP environment
Maintain Data Integrity Assessments with the current Amgen and Industry standards
Build the business processes to support the project scope in alignment with project timelines
Develop detailed specification and engineering policies and procedures that affect multiple organizational units
Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO) in a fast-paced environment

What we offer

Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans and bi-annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possible

Fulltime

Senior Manufacturing Systems Engineer: Automation (Wednesday - Saturday Shift)

Be part of Amgen's newest and most advanced drug substance manufacturing plant. ...

Location

United States , Holly Springs

Salary:

136906.95 - 185227.05 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

High School Diploma / GED and10years of Engineering experience OR Associate's Degreeand8years of Engineering experience OR Bachelor's Degree and4years of Engineering experience OR Master'sDegree and2years of Engineering experience OR DoctorateDegree

Job Responsibility

Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS)
Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions
Collaborate with business partners to understand how automation can improve workflow and productivity
Synthesize requirements from clients, customers or end-users to develop the best automation solutions
Provide clear documentation for delivered solutions and processes
work closely with QA partners while supporting computerized systems validation processes in a GxP environment
Maintain Data Integrity Assessments with the current Amgen and Industry standards
Build the business processes to support the project scope in alignment with project timelines
Develop detailed specification and engineering policies and procedures that affect multiple organizational units
Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO) in a fast-paced environment

What we offer

Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans and bi-annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possible

Fulltime

Senior Manufacturing Systems Engineer: Automation

Be part of Amgen's newest and most advanced drug substance manufacturing plant. ...

Location

United States , Holly Springs

Salary:

147421.00 - 177467.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

High School Diploma / GED and 10 years of Engineering experience
Associate’s Degree and 8 years of Engineering experience
Bachelor’s Degree and 4 years of Engineering experience
Master’s Degree and 2 years of Engineering experience
Doctorate Degree
Degree in Electrical Engineering, Computer Science, Chemical Engineering, Biotech Engineering, or related field
Direct knowledge of Automation System design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation
Extensive understanding and background in programming, design, installation and lifecycle management of manufacturing process controls, automation and field instrumentation technologies
Experience with Emerson DeltaV DCS system, Process Control Network design including network segregation, virtual infrastructure design and implementation, and ability to perform sophisticated troubleshooting activities, system integration using OPC, Foundation Fieldbus, Profibus, and DeviceNet technologies
Ability to interpret and apply GAMPs and GMPs and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88, and S95

Job Responsibility

Provide automation technical leadership to a group of automation engineers
Work hand in hand with the capital project team to deliver robust process automation systems to operate the new plant
Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS)
Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions
Collaborate with business partners to understand how automation can improve workflow and productivity
Synthesize requirements from clients, customers or end-users to develop the best automation solutions
Provide clear documentation for delivered solutions and processes
work closely with QA partners while supporting computerized systems validation processes in a GxP environment
Maintain Data Integrity Assessments with the current Amgen and Industry standards
Build the business processes to support the project scope in alignment with project timelines

What we offer

Competitive and comprehensive Total Rewards Plans that are aligned with local industry standards

Fulltime

Senior Manufacturing Systems Engineer: Automation - PLC

Be part of Amgen's newest and most advanced drug substance manufacturing plant. ...

Location

United States , Holly Springs

Salary:

147421.00 - 177467.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

High School Diploma / GED and 10 years of Engineering experience
Associate’s Degree and 8 years of Engineering experience
Bachelor’s Degree and 4 years of Engineering experience
Master’s Degree and 2 years of Engineering experience
Doctorate Degree
Degree in Electrical Engineering or Computer Science, Chemical Engineering, or Biotech Engineering
Direct knowledge of PLC design, experience in controls engineering and troubleshooting with GMP biopharmaceutical production facility and utility equipment/systems automation
Extensive understanding and background in programming, design, installation, and lifecycle management of standalone controls, PLC, and field device/instrumentation technologies
Experience with Rockwell industrial automation hardware and systems, ability to perform sophisticated troubleshooting activities, System Integration using OPC, Foundation Fieldbus, Profibus, and DeviceNet technologies
Ability to interpret and apply GAMPs and GMPs and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88, and S95

Job Responsibility

Provide automation technical leadership to a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP Drug Substance Plant Operations
Work hand in hand with the capital project team to deliver robust automation systems to operate the new plant utility and standalone systems
Develop and maintain automation solutions utilizing various PLC's such as Allen Bradley, Siemens, etc. and integration with the Emerson DeltaV system
Develop and maintain Supervisory Control and Data Acquisition system (SCADA), Trailblazer reporting system, and equipment PLC’s and interface hardware
Lead and support standalone system implementation and start-up, participate and provide technical guidance in the control panel / Human Machine Interfaces (HMI) layout and design including power distribution, grounding requirements, I/O assignments, etc
Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions
Lead in continuous improvement and innovation initiatives for efficient operation and sustainability improvements of standalone systems
Collaborate with business partners to understand how standalone systems can improve workflow and productivity. Synthesize requirements from clients, customers, or end-users to develop the best automation solutions
Provide clear documentation for delivered solutions and processes
work closely with QA partners while supporting computerized systems validation processes in a GxP environment. Maintain Data Integrity Assessments with the current Amgen and Industry standards

What we offer

Competitive and comprehensive Total Rewards Plans that are aligned with local industry standards

Fulltime

Senior Manufacturing Engineer – Virtual Engineering, Propulsion Systems

At General Motors, we are redefining manufacturing through advanced digital engi...

Location

United States , Warren

Salary:

Not provided

General Motors

Expiration Date

Until further notice

Requirements

5+ years of manufacturing experience
5+ years of hands-on experience with Siemens PLM and CAD systems, preferably NX
3+ years of hands-on experience with Siemens Tecnomatix Process Simulate or similar platforms
Basic understanding of PLC and robot programming, preferably Fanuc
Exposure to Agile methodologies and tools
Experience with business integration testing
Familiarity with powertrain components and manufacturing processes
Knowledge of data modeling and system architecture
Bachelor's degree in Engineering or related field, or equivalent practical experience

Job Responsibility

Lead virtual simulation and emulation initiatives that support manufacturing engineering and digital transformation efforts
Create and improve standardized virtual engineering processes that drive efficiency across equipment sourcing and project execution
Support the storage, processing, and accessibility of data across multiple platforms to enable scalability and collaboration
Partner with Process Engineering Leads and Machine Tool Builders to develop digital twins of physical manufacturing systems for simulation, testing, and real-time monitoring
Evaluate, design, and optimize manufacturing systems using Teamcenter Manufacturing Process Planner, Process Simulate, Integrated Emulation, and XR tools
Collaborate with Central Lead Manufacturing Engineers and IT teams to ensure consistency in simulation and emulation project execution across propulsion programs and manufacturing disciplines
Provide technical direction for the investigation, business integration testing, and deployment of both new and legacy virtual software and hardware utilities
Stay current on advancements in process simulation technology, industry trends, and emerging best practices

What we offer

This job may be eligible for relocation benefits

Fulltime

New

Senior Manufacturing Engineer – Solid State Power Pulse Modules (SSPPM)

The Senior Manufacturing Engineer – Solid-State Power Pulse Modules (SSPPM) supp...

Location

United States , San Diego

Salary:

102375.00 - 153563.00 USD / Year

ASML

Expiration Date

Until further notice

Requirements

Bachelor’s degree in Mechanical, Electrical, Industrial, Manufacturing or related Engineering field
5+ years of experience in manufacturing or process engineering, preferably in power distribution, electronics or precision electro-mechanical assemblies
Experience with statistical methods including SPC, DOE, FMEA, and process capability analysis
Hands‑on experience troubleshooting complex manufacturing processes in a production environment
Familiarity with documentation control, BOM structures, and change management processes
Proficiency with data analysis tools (e.g., JMP, Minitab, Excel, or similar)

Job Responsibility

Own and sustain solid-state power-pulse module (SSPPM) manufacturing processes to ensure stable quality, yield, and throughput
Monitor and improve process performance using data analysis (yield trends, defect paretos, process capability/Cpk)
Apply statistical and structured problem‑solving methods (SPC, DOE, FMEA) to identify root causes, reduce variation, and ensure process capability
Lead troubleshooting of complex electro‑mechanical system build and test issues
drive containment, corrective actions, and prevention of recurrence
Partner cross‑functionally with Quality, Production, and Design Engineering to resolve non‑conformances and improve product robustness
Maintain and continuously improve manufacturing documentation, including work instructions, standard work, and control plans
Execute change management activities (COs, TDNs) to ensure controlled and compliant process updates
Identify and implement improvements to yield, cycle time, cost, and equipment performance using Lean manufacturing principles
Support equipment optimization, tooling improvements, and preventive maintenance strategies

What we offer

Medical insurance
Dental insurance
Vision insurance
Basic life insurance
401k plan
8 hours of vacation leave every month
13 paid holidays per calendar year

Fulltime

Senior Manufacturing Engineer – Factory Performance & Industrial Engineering

As a Manufacturing Engineer at ASML, you play a vital role in the creation of ad...

Location

United States , San Diego

Salary:

102375.00 - 153563.00 USD / Year

ASML

Expiration Date

Until further notice

Requirements

Bachelor’s degree or higher in Mechanical Engineering, Electrical Engineering, Industrial Engineering, or a related field
4+ years of relevant experience in manufacturing engineering or industrial engineering roles
Experience reading technical drawings (GD&T), creating work instructions, and applying statistical methods to engineering problems
Working knowledge of Lean Manufacturing, 5S, 8D, FMEA, and 5 Why problem solving
Familiarity with Bill of Materials (BOM) structures
Ability to work in a cleanroom manufacturing environment
Hands on experience with Excel, Python, MATLAB, Minitab, JMP, Visio, or similar tools
Demonstrated curiosity, structure, and passion for working directly with production teams on the shop floor
Experience in a manufacturing environment is preferred
Familiarity with process optimization tools and quality assurance methods

Job Responsibility

Develop, implement, and optimize manufacturing processes for ASML products
Identify and resolve production issues to maintain high standards
Collaborate with team members to improve workflow and safety
Support the introduction of new products and technologies into manufacturing
Monitor and analyze data to drive continuous improvement
Train and guide operators and technicians on best practices
Ensure compliance with environmental and safety regulations
Analyze cycle time, throughput, bottlenecks, and material flow to identify waste and drive factory level improvements
Conduct industrial engineering studies including work content assessment, layout evaluation, and material flow optimization
Perform SPC and process capability analysis to identify sources of variation and implement corrective measures to reduce part to part variation

What we offer

Medical, dental, vision, and basic life insurance
401k plan
8 hours of vacation leave every month
13 paid holidays throughout the calendar year

Fulltime

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Senior Manufacturing Systems Engineer

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