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Senior Manager – Drug Substance Technology & Engineering

United States, Thousand Oaks Employment contract 148715.15 - 201202.85 USD / Year · Job Posted June 15, 2026
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Job Description

Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Job Responsibility

  • Support the development, scale-up, tech transfer and manufacturing execution of cGMP clinical and commercial downstream purification processes including, but not limited to harvest, clarification, chromatography (Protein A, AEX, CEX, etc), viral filtration, UF/DF, and sterile filtration
  • Apply engineering principles and statistical analysis in order to: Identify, develop and implement downstream process improvements into the manufacturing facility
  • Resolve technical issues observed during scale-up and/or manufacturing execution of purification processes
  • Manage escalation and on the floor support as required to achieve successful scale-up and manufacturing objectives
  • Interface with process development teams to ensure processes are robust and are designed to deliver all quality attributes and enable manufacturing success
  • Collaborate with Process Development, Quality, Manufacturing, Regulatory, Validation and Supply Chain to drive continuous improvements into our business processes
  • Lead site activities for continuous process verification, process monitoring, optimization, complex investigation, and product life cycle management
  • Ensure safety and compliance of process development activities
  • Collaborate with other site-functions and network drug substance teams in delivering plant goals
  • Lead cross-functional teams to resolve complex problems while meeting quality, schedule, and cost objectives
  • Ensure manufacturing operations are aligned with the registered process
  • Provide support for regulatory filing, inspection, and other CMC activities
  • Serve as member of the ATO DSTE leadership team utilizing network thinking and innovative approaches to advance the drug substance organizational capabilities
  • Supervising Others / Team Experience: Create multi-year technical strategies for advancing business performance
  • Ensures that safe practices are followed
  • Provides mentoring and expertise to staff on the downstream team
  • Motivates, develops, and coaches staff while promoting team collaboration
  • Applies effective management practices in the direction and development of others
  • Leadership and Influence: Identifies and negotiates resources and develops timelines for project activities
  • Collaborates within the department and interdepartmentally
  • Provides scientific and technical leadership
  • Ensure department staff are adequately developed and trained
  • Provides adequate feedback through coaching and effective performance appraisal and development planning
  • Initiates and encourages scientific collaboration with groups outside the department
  • Manage project resources (material, labor, time, etc.), and elevate relevant issues to project lead and line-management
  • Build and maintain effective collaborations with partner organizations
  • Decision Making and Judgment: Anticipates, proactively detects, and addresses problems related to departmental and interdepartmental activities
  • Inform and consults department head and senior staff appropriately

Requirements

  • Doctorate degree and 2 years of biologics process development or commercial-scale technical support experience
  • Master's degree and 6 years of biologics process development or commercial-scale technical support experience
  • Bachelor's degree and 8 years of biologics process development or commercial-scale technical support experience
  • Associate's degree and 10 years of biologics process development or commercial-scale technical support experience
  • High school diploma / GED and 12 years of biologics process development or commercial-scale technical support experience
  • minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources

Nice to have

  • 8+ years of experience in a technical role supporting biotechnology processes within regulated environments (i.e., cGMP)
  • 5+ years directly managing people and/or leadership experience leading teams, projects, and programs or directing the allocation of resources
  • Strong and in-depth expertise in purification processes
  • Experience in process scale-up, technology transfer, process validation, troubleshooting, and complex investigation
  • Strong oral and verbal communication skills, interact effectively with diverse internal and external stakeholders
  • Experience developing staff to reach their full potential
  • Knowledgeable in regulatory filings and inspections
  • Familiarity in operational aspects of commercial biopharma manufacturing
  • Familiarity in statistical analysis, analytical methods, and product quality attributes relevant to biological processing

What we offer

  • Health and welfare plans for staff and eligible dependents
  • Financial plans with opportunities to save towards retirement or other goals
  • Work/life balance
  • Career development opportunities
  • Retirement and Savings Plan with generous company contributions
  • Group medical, dental and vision coverage
  • Life and disability insurance
  • Flexible spending accounts
  • Discretionary annual bonus program
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
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