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Cabaletta Bio Inc Logo Cabaletta Bio Inc · IT - Administration

Senior IT Systems Administrator

United States, Philadelphia · Job Posted May 03, 2026
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Job Description

Reporting to the Director of IT and Data Sciences, we are seeking a Senior IT Systems Administrator to support the implementation, operation, and continuous improvement of Cabaletta’s IT infrastructure and collaboration systems. This individual will work across departments to ensure systems are reliable, secure, and aligned with business needs. This is a hands-on role requiring strong experience with Microsoft 365, AWS hybrid cloud environments, and Linux/Windows systems. The role also involves close collaboration with internal stakeholders and external service providers to support consistent, high-quality IT service delivery. This role is located in Center City, Philadelphia. We operate in a hybrid work environment, with an expectation of 2+ days per week in the office as needed.

Job Responsibility

  • Own and contribute to the design, implementation, configuration, and support of servers, network devices, and firewalls in collaboration with IT and business teams
  • Own the operational health of IT systems, including end-user support, break-fix activities, monitoring, patch management, system backup/recovery, system administration, troubleshooting, and issue resolution
  • Lead and coordinate Tier 2/3 escalations, ensuring timely resolution with internal stakeholders and external partners
  • Serve as a primary technical point of contact for external service providers, ensuring alignment with operational and security expectations
  • Partner with external support providers to maintain consistent service delivery, including responsiveness, quality, and adherence to service expectations
  • Review escalations, recurring issues, and incident trends to identify improvement opportunities and reduce operational risk
  • Coordinate and communicate infrastructure and system changes, ensuring proper documentation and alignment with internal processes
  • Collaborate with internal stakeholders and service providers to prioritize work and support a high-quality end-user experience
  • Contribute to continuous improvement of IT service delivery processes and operational practices
  • Administer and support core Linux and Microsoft technologies across cloud and hybrid environments
  • Maintain and support AWS hybrid cloud environments (EC2, VPC, Elastic Load Balancing, RDS, S3)
  • Maintain and support Microsoft 365 systems (Exchange, SharePoint, Teams, Entra ID)
  • Support implementation and maintenance of cybersecurity controls across infrastructure and cloud environments, including identity, access, and endpoint protections
  • Support identity and access management practices, including role-based access and least privilege principles
  • Assist in monitoring, responding to, and remediating security events with internal teams and external partners
  • Contribute to vulnerability management activities, including patching, system hardening, and periodic security reviews
  • Maintain business continuity and disaster recovery systems, including periodic testing for compliance and data retention
  • Ensure IT systems comply with cybersecurity and regulatory standards, including participation in audits, risk assessments, and remediation efforts
  • Create and maintain comprehensive IT documentation (SOPs, user guides, training materials, test plans, validation documents)
  • Support lifecycle management of IT systems across on-premise and cloud platforms
  • Collaborate with QA/CSV teams on validation processes, including development and execution of test scripts
  • Support data integrity processes for IT systems and laboratory environments
  • Provide training and support to staff and partners on effective use of technology
  • Perform other assignments and projects as required

Requirements

  • Bachelor’s degree with 5+ years of experience as a Systems Administrator or similar role in biotech, pharmaceutical, or life sciences industries
  • Experience with LAN/WAN networks, including wireless and firewall management
  • Strong experience with AWS services, including EC2, VPC, Elastic Load Balancing (ALB/NLB), RDS, and S3
  • Strong experience with Windows Server (2016/2019/2022) and RHEL (7/8/9)
  • Experience supporting Microsoft 365 applications, including Exchange, SharePoint, Teams, and Entra ID (SSO, SAML, OIDC)
  • Solid understanding of Active Directory, Group Policy, and file system permissions
  • Experience with backup and recovery platforms
  • Experience supporting cybersecurity practices in a regulated environment, including patch management, access controls, and endpoint security
  • Familiarity with firewalls, network security concepts, and identity management
  • Excellent problem-solving, communication, and organizational skills
  • Strong curiosity and ability to learn quickly in a fast-paced environment
  • Strong client support orientation and ability to work with users across varying technical skill levels
  • Comfortable operating in a growing, dynamic organization

Nice to have

  • Experience supporting segmented or regulated network environments
  • Exposure to security monitoring tools (e.g., SIEM, endpoint detection and response)
  • Experience working with external service providers or managed services environments

What we offer

  • health and retirement
  • PTO
  • stock option plans
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