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Senior Infrastructure Engineer

United States, Philadelphia · Job Posted July 03, 2026
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Job Description

The Senior Infrastructure Engineer is responsible for the administration, maintenance, security, and continuous improvement of Cabaletta Bio's infrastructure and cloud platforms. This role provides hands-on technical support for AWS, Windows and Linux server environments, networking, firewalls, cybersecurity controls, backup and disaster recovery capabilities, and emerging platform technologies.

Job Responsibility

  • Administer and support AWS cloud infrastructure, including EC2, VPCs, security groups, storage services, monitoring, and related cloud resources.
  • Administer, maintain, and troubleshoot Windows Server and Linux server environments.
  • Monitor infrastructure performance, availability, capacity, and reliability, and participate in planning, upgrades, patching, lifecycle management, and continuous improvement initiatives.
  • Maintain infrastructure documentation, architecture diagrams, technical standards, and operating procedures, and assist with development and implementation of operational processes and technical best practices.
  • Support, maintain, and troubleshoot network infrastructure, including firewalls, VPN connectivity, routing, DNS, DHCP, and wireless networking services, across cloud, server, and application environments.
  • Assist with network design reviews and infrastructure improvements, and collaborate with managed service providers and infrastructure vendors to resolve complex technical issues.
  • Design and support cloud-native and containerized workloads utilizing technologies such as Docker, ECS, EKS, and related platforms.
  • Assist with application hosting, platform administration, and infrastructure services supporting internal business systems and scientific computing workloads, and participate in cloud modernization, infrastructure automation, and platform engineering initiatives.
  • Support infrastructure requirements for data platforms, internal applications, and future AI-enabled solutions.
  • Implement and maintain infrastructure security controls and cybersecurity best practices.
  • Support vulnerability remediation, system hardening, patch management, access controls, and security monitoring activities.
  • Review infrastructure security recommendations and assist with implementation of corrective actions, collaborating with internal and external security resources to address identified risks.
  • Support security audits, assessments, and compliance initiatives as required.
  • Support backup administration, recovery procedures, disaster recovery planning, and infrastructure resilience initiatives, including participation in DR exercises, testing activities, and business continuity planning.
  • Maintain documentation supporting recovery procedures and infrastructure continuity requirements.
  • Serve as a technical point of contact for managed service providers, cloud partners, and infrastructure vendors.
  • Coordinate technical activities, projects, escalations, and support requests across external partners, reviewing vendor and partner recommendations to provide technical input and implementation support.
  • Communicate effectively with business users, scientific teams, and technology partners, providing technical guidance and support during infrastructure-related incidents, projects, and technology initiatives.
  • Partner closely with the Senior IT Systems Administrator and broader IT team to support enterprise technology services.

Requirements

  • Bachelor's degree in Information Technology, Computer Science, Engineering, or a related field, or equivalent experience.
  • 5+ years of progressive infrastructure administration experience.
  • Experience supporting biotechnology, pharmaceutical, or life sciences organizations, including work within GxP-regulated environments and experience with computer system validation (CSV), change control processes, and compliance-driven operations.
  • Experience administering AWS cloud environments.
  • Strong experience administering Linux and Windows Server environments.
  • Experience supporting network infrastructure, firewalls, VPNs, DNS, and related technologies.
  • Foundational cybersecurity experience, including vulnerability remediation, system hardening, access management, and security best practices.
  • Experience supporting backup, recovery, and disaster recovery processes.
  • Strong troubleshooting, root cause analysis, and problem-solving skills.
  • Strong written and verbal communication skills with the ability to work effectively with both technical and non-technical stakeholders.
  • Ability to work independently while collaborating effectively with internal teams, vendors, and external partners.

Nice to have

  • Experience supporting scientific, laboratory, clinical, manufacturing, quality, or regulatory business functions, including validated applications and infrastructure platforms.
  • Experience with Docker, containerized workloads, ECS, EKS, or Kubernetes.
  • Experience with infrastructure automation and scripting using PowerShell, Bash, Python, or similar technologies.
  • Experience supporting hybrid cloud environments.
  • AWS, Microsoft, Linux, networking, or security certifications.

What we offer

  • health and retirement
  • PTO
  • stock option plans

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