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Senior Engineer Manager - Upstream

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Amgen

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Location:
United States , Holly Springs

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Category:
Manufacturing

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Contract Type:
Not provided

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Salary:

158914.00 - 191350.00 USD / Year
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Job Description:

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleXBatch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleXBatch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

Job Responsibility:

  • Be responsible for the department capital portfolio and project management of small capital projects at the drug substance facility
  • Provide technical leadership to a team of manufacturing support engineers supporting commercial production operations with emphasis on Drug Substance bioprocessing equipment
  • Establish clear expectations and priorities to staff
  • Encourage a culture of continuous improvement, partnership, and knowledge sharing
  • Provide development opportunities, feedback, and actively listen to staff
  • Cultivate a culture of safety ensuring the well-being of all staff members and drive efforts to reduce safety risks
  • Provide technical support to troubleshoot, identify and resolve process and system issues as needed
  • Be knowledgeable about compliance and regulatory aspects for equipment validation, operation and maintenance
  • Effectively collaborate with key customers and support groups (e.g. Manufacturing, Quality, Process Development, Maintenance, network partners)
  • Ensure all tasks and projects are accomplished in a safe manner
  • Employ Business Analytics to assess performance and identify improvement opportunities
  • Lead Sustainability Program Management of Multi-faceted, Cross-functional, Network Initiative
  • Collaborates with leadership to set strategy and business objectives
  • Foster and maintain relationships with key stakeholders
  • Establish balanced scorecard of strategic and operational key performance indicators (KPI) in line with industry best practices to monitor, trend and analyze equipment performance, sustainability and reliability programs
  • Ensure action plans are established to address performance gaps or opportunities
  • Communicate gaps and establish the proper escalation process to the stakeholders
  • Identify opportunities to optimize organizational efficiency
  • Leads engineering and contractor evaluation and selection process

Requirements:

  • High school diploma / GED and 12 years of Engineering and/or Project Management experience
  • Associate’s degree and 10 years of Engineering and/or Project Management experience
  • Bachelor’s degree and 8 years of Engineering and/or Project Management experience
  • Master’s degree and 6 years of Engineering and/or Project Management experience
  • Doctorate degree and 2 years of Engineering and/or Project Management experience
  • Minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation of resources

Nice to have:

  • Bachelor’s degree in chemical engineering or related technical field
  • 5+ years’ experience in engineering in a manufacturing support environment with 3+ years’ experience in the Pharmaceutical or Biotechnology industries
  • Demonstrated people management/leadership experience
  • Experience with Mammalian Cell Culture, Protein Purification, Clean Utilities, CIP, SIP and Production Services. Upstream unit operation experience such as bioreactor or harvest equipment
  • Familiarity designing, troubleshooting, and operating equipment used in cell culture manufacturing including disposable technologies
  • Experience with Tech Transfer, Process Design, and Commissioning & Qualification
  • Experience with validation and change control methodology
  • Direct experience with regulated environments (i.e., cGMP, OSHA, EPA) including detailed understanding of cGMPs
  • Excellent written and verbal communication skills
  • Demonstrated interpersonal and facilitation skills and ability to work in a collaborative team-based environment
  • Ability to apply analytical skills to evaluate and interpret complex problems using multiple sources of information
  • Demonstrated ability to lead and influence cross-functional teams and embrace a team-based culture
  • Familiarity with designing and operating equipment used in biopharmaceutical manufacturing
  • Demonstrated experience in applying Operational Excellence and Lean Manufacturing
What we offer:
  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans and bi-annual company-wide shutdowns
  • Flexible work models, including remote work arrangements, where possible

Additional Information:

Job Posted:
February 19, 2026

Employment Type:
Fulltime
Work Type:
On-site work
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