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Senior Director Immunology

SAB Biotherapeutics

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Location:
United States , Sioux Falls

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

Not provided
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Job Description:

The Senior Director Immunology will lead discovery, preclinical development, and clinical translation of a novel multi-specific immunotherapy platform for complex autoimmune diseases. The incumbent will be a key participant in shaping translational strategy, driving biomarker innovation, overseeing assay development and immunophenotyping to support clinical decision-making and pipeline advancement. The role requires deep scientific expertise, vision and proven success advancing immunology-focused therapeutics in an industry setting. The Senior Director Immunology will also represent SAB at industry conferences and to other stakeholders, including investors and industry analysts.

Job Responsibility:

  • Oversee the design, execution, and validation of biomarker discovery, flow-based immunophenotyping, and patient-stratification assays for clinical trials
  • Direct experimental planning and data analysis, ensuring high-quality data interpretation, reporting, and communication to internal stakeholders and governance bodies
  • Partner with translational, clinical, regulatory, and development teams to integrate biomarker and assay strategies into protocols, regulatory documents, and clinical plans
  • Provide strategic leadership across Research and Translational Immunology, guiding disease biology insights, mechanism-of-action studies, and biomarker-enabled clinical strategies
  • Participate in translational and biomarker planning for discovery through clinical stages, including immunophenotyping, pharmacodynamic analyses, and molecular/cellular profiling
  • Manage and collaborate with CROs, external vendors, and academic partners to support assay development, method innovation, and data generation
  • Foster an excellent research environment, supporting lab-based teams in culture, collaboration, operations, and safety
  • Represent Translational Science and Immunology internally and externally, presenting scientific findings and program progress. This includes presenting to investors, analysts and at industry conferences
  • Identify and pilot innovative technologies to enhance translational science and immunotherapy development
  • Ensure compliance with global regulatory standards (FDA/CBER, EMA, MHRA, TGA) and maintain awareness of scientific and technical advancements relevant to autoimmune drug development

Requirements:

  • PhD with 10+ years’ experience in Immunology or related field, with biotech/pharma industry experience required
  • Deep expertise in immunology, T-cell biology, autoimmune mechanisms, and therapeutic antibodies
  • Proven proficiency in clinical immunophenotyping, particularly advanced flow cytometry
  • Strong record of accomplishment in advancing immunology-focused therapeutics and leading translational/biomarker initiatives
  • Experience managing laboratory scientists and analytical teams
  • Skilled in molecular and cellular assay development within industry settings
  • Familiarity with global regulatory pathways (FDA, EMA, MHRA, TGA)
  • Highly collaborative, innovative, with strong written and spoken communication skills and ability to lead in a matrixed, distributed environment
  • High level of emotional intelligence and the demonstrated ability to be an effective listener with strong diplomacy and presentation skills
  • Previous experience meeting with and presenting to internal and external stakeholders to include, but not limited to BOD, investors, analysts and at industry conferences

Additional Information:

Job Posted:
January 26, 2026

Employment Type:
Fulltime
Work Type:
Remote work
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