Senior Director Immunology Job at SAB Biotherapeutics (Sioux Falls)

Senior Medical Director, Clinical Development

Cabaletta is seeking an experienced, highly motivated hands-on physician leader ...

Location

United States , Philadelphia

Salary:

Not provided

Cabaletta Bio Inc

Expiration Date

Until further notice

Requirements

D., M.D./Ph.D. degree or equivalent required
Board Certification, Board Eligibility, or clinical experience in the field of Rheumatology and/or Immunology highly desirable
7+ years of experience in clinical research, including the design and execution of complex clinical trials, with a pharmaceutical or biotech company
Experience with or exposure to the development of adoptive cell therapies or biologic therapies is desirable
Experience with Health Authority interactions and submission of clinical regulatory documents is desirable
Strong written and verbal communication skills
ability to easily engage with investigators and key external experts
and ability to effectively present at conferences, advisory meetings, and other public for a
Engaged, hands-on, independent, and goal-oriented mentality
willingness to work in highly dynamic work environment

Job Responsibility

Provide medical leadership for various programs from first-in-human studies through registrational studies
Formulate study designs, lead protocol development, partner with internal cross-functional teams in study start-up activities, and collaborate with clinical investigators, key external experts, and Health Authorities
Participate in direct, hands-on involvement in all aspects of study conduct clinical activities, working with clinical operations, including data review, analysis, and reporting that conform to the ethical, safety, and quality standards of Cabaletta, GCP, and Health Authorities
Become an expert and remain current in the relevant therapeutic areas and in the field of cell and gene therapy through review of the scientific literature, interactions with key external experts, and attendance at relevant scientific meetings
Actively contribute during Health Authority interactions
Review available preclinical data that could inform the design of future clinical trials
Present at site evaluation and site initiation visits as applicable
In partnership with relevant cross-functional team members, actively engage in the preparation of Clinical Study Reports, Annual Reports and other safety reports, Health Authority pre-meeting packages, Investigator Brochures, periodic clinical reports, and BLA submission documents
Collaborating with cross-functional groups, formulate publication strategy including active participation in authoring, preparation and review of manuscripts, conference abstracts and presentations and other external presentations of clinical data

What we offer

health and retirement, PTO, and stock option plans

Director, Clinical Pharmacology

We are seeking a motivated Director, Clinical Pharmacology, to join our growing ...

Location

United States

Salary:

230000.00 - 260000.00 USD / Year

Apogee Therapeutics

Expiration Date

Until further notice

Requirements

PhD or PharmD with relevant expertise in clinical pharmacology or pharmaceutical science
5+ years of direct industry experience in conducting clinical stage drug development
Experienced in developing clinical pharmacology plans and authoring relevant sections of clinical and regulatory documents
Knowledge and experience in the application of current practices in the areas of clinical pharmacology, pharmacokinetic and pharmacodynamic principles, drug metabolism, bioanalysis, biopharmaceutics
Fluency in model-informed drug development
Experience working with external CROs
Proficient in using common PK/PD modeling software (such as Phoenix WinNonlin, Prism, and other similar tools)
Ability to work proactively and effectively, with exceptional creative problem-solving skills and self-motivation
Ability to work in cross-functional teams within a highly dynamic environment
Strong project management skills with a high sense of urgency, ability to collaborate and influence effectively cross-functionally

Job Responsibility

Lead clinical pharmacology programs in immunology & inflammation, providing strategic planning for drug development activities
Influence, decide, and recommend key clinical pharmacology strategies across the drug development spectrum
Develop and help implement quantitative approaches to drug development programs
Work in close collaboration with different functions
Lead and present key Clinical Pharmacology information to teams, senior leaders, regulatory agencies, and external partners
Independently lead Clinical Pharmacology/PK/PD activities and provide scientific and strategic expertise
Support pediatric development, including protocol development and dose selection
Develop and oversee implementation of clinical pharmacology studies from protocol development to final study reporting
Lead the analysis, interpretation, and reporting of clinical PK/PD data, author clinical study reports
Develop and execute and/or oversee PK/PD modeling strategies to describe the relationship between drug exposure and response

What we offer

Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
Three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave
Commitment to growing you professionally and providing access to resources to further your development
Apogee offers regular all team, in-person meetings to build relationships and problem solve

Fulltime

Target Validation Sr Director

This research based Senior Director role will be responsible for building, leadi...

Location

United States , South San Francisco

Salary:

265405.00 - 312459.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree PhD in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 7 years of scientific leadership experience in biotech, pharma or equivalent research environments
OR Master’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 10 years of scientific leadership experience in biotech, pharma or equivalent research environments
OR Bachelor’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant disciplineand 12 years of scientific leadership experience in biotech, pharma or equivalent research environments

Job Responsibility

Lead and develop a multidisciplinary organization of ~25 scientists within Research Biology
Integrate diverse experimental disciplines and workflows to ensure coordinated execution and efficient delivery of novel molecular insights
Establish platform priorities, resource allocation, and capacity planning in alignment with Research Biology and Therapeutic Area priorities
Define clear roles, responsibilities, and seamless handoffs across teams and partnering organizations
Drive adoption of automated experimental workflows, and integration of AI/ML to enable efficient experimentation across programs
Serve as a senior scientific partner to Target Discovery and Therapeutic Areas
Set clear expectations and enable scientists with diverse skill sets to collaborate effectively and contribute to early research pipeline
Serve as a core member of Target Discovery Advisory Forum, and play a key role in target discovery, validation and prioritization. Engage, influence, and align therapeutic area stakeholders
Guide team members in synthesizing and communicating complex scientific and data-driven insights to key stakeholders and advisory forum
Contribute to fostering a highly collaborative, creative, dynamic and cutting-edge research environment

What we offer

competitive benefits
collaborative culture
health and welfare plans for staff and eligible dependents
financial plans with opportunities to save towards retirement or other goals
work/life balance
career development opportunities
Retirement and Savings Plan with generous company contributions
group medical, dental and vision coverage
life and disability insurance
flexible spending accounts

Fulltime

New

Senior Director, Molecular Pathology and Cell Biology

Moderna is seeking a strategic and scientifically rigorous leader to serve as Sr...

Location

United States , Cambridge

Salary:

196700.00 - 353400.00 USD / Year

Moderna

Expiration Date

Until further notice

Requirements

PhD, MD, or equivalent in Pathology, Cell Biology, Immunology, Cancer Biology, or related discipline
12+ years of experience in translational research, molecular pathology, or functional cell biology within biotech, pharma, or academia
Strong understanding of advanced tissue-based assay strategies, including highly multiplexed spatial profiling approaches and AI-powered image analysis
Significant experience in cell-based functional assays, including cytotoxicity and immune effector assays
Experience building and deploying advanced experimental model systems (3D cultures, explants, co-culture platforms)
Demonstrated experience supporting translational research programs and contributing to development-stage decision-making
Proven leadership of multidisciplinary scientific teams within a matrixed organization
Strong communication skills and ability to influence across Research and Development functions

Job Responsibility

Lead and integrate high-performing Molecular Pathology and Cell Biology teams while defining and executing a forward-looking translational strategy aligned with therapeutic area priorities and portfolio needs
Serve as a scientific thought partner to Research, Translational Medicine, and Clinical Biomarker leaders, shaping priorities and enabling effective cross-functional collaboration
Set the strategic direction for Molecular Pathology support of target and tissue expression profiling across normal and disease tissues to inform target selection, program prioritization, and translational hypothesis development
Guide the deployment of routine and advanced tissue-based assays, novel spatial profiling approaches, and the continued evolution of the digital pathology infrastructure to ensure fit-for-purpose application across programs
Oversee development and execution of cell-based functional assays including cytotoxicity, cell-killing, ADCC, and pathway interrogation assays
Drive innovation in advanced experimental model systems including organoids, patient-derived explants, and co-culture systems
Establish quality standards, reproducible workflows, and scalable infrastructure to deliver high-quality data supporting Therapeutics Research, Translational Medicine, and, when appropriate, IND-enabling efforts

What we offer

Best-in-class healthcare coverage, plus voluntary benefit programs
A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
Family planning benefits, including fertility, adoption, and surrogacy support
Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
Savings and investment opportunities to help you plan for the future
Location-specific perks and extras
Eligible for an annual discretionary bonus, other incentive compensation, or equity award

Fulltime

Vice President, Inflammatory and Immune Disease Biomarker Development

We are seeking a highly experienced and motivated individual to lead our biomark...

Location

United States

Salary:

320000.00 - 355000.00 USD / Year

Apogee Therapeutics

Expiration Date

Until further notice

Requirements

PhD or MD in a relevant scientific discipline
At least 15 years of track-record in senior leadership roles in biomarker discovery and development, preferably in the field of inflammatory and immunology diseases
Proven success in leading biomarker discovery programs from ideation to clinical validation
Focused understanding on late-stage clinical development including Phase 3 trials with biologics and BLAs is required
Experience in I&I, atopic dermatitis, asthma, COPD and/or EOE a plus
Excellent communication skills and ability to articulate and communicate complex strategic vision
Deep hands-on knowledge of the antibody development process and regulatory requirements for biomarkers in clinical trials and for BLA-submissions
Strong preference for candidates with late stage clinical and post launch experience
Expertise in collaborating with external partners and key opinion leaders
Strong leadership and communication skills fully aligned with our C.O.R.E. values

Job Responsibility

Lead the strategic planning and execution of biomarker discovery and development programs for inflammatory and immunology diseases, focusing on atopic dermatitis, asthma, COPD and EOE and particularly late-stage clinical development
Develop and articulate the late-stage clinical and post-launch strategic vision for the biomarker programs to internal and external stakeholders
Collaborate with internal and external stakeholders to integrate our biomarker discovery and development efforts into our development programs, including clinical trials and BLAs
Oversee the Biomarker Discovery and Development team to drive efforts through a combination of in vitro/in vivo and in silico data analyses, in house and in collaboration with external partners
Together with the Senior Director-Biomarker Discovery and Development develop and implement biomarker strategies to demonstrate the clinical utility of novel biomarkers and the distinction of patient populations and responders as well as additional indications
Stay current on emerging trends and technologies in biomarker discovery and development, and implement best practices to ensure the success of our programs
Provide strategic input and leadership to cross-functional program and functional teams to drive the development of novel, innovative therapies for inflammatory and immunology diseases

What we offer

Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
Three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave
Commitment to growing you professionally and providing access to resources to further your development
Apogee offers regular all team, in-person meetings to build relationships and problem solve

Fulltime

Senior Director, Seasonal Vaccines

You will help set scientific strategy for a seasonal viral vaccine program based...

Location

United States , Pearl River

Salary:

214900.00 - 341100.00 USD / Year

Pfizer

Expiration Date

Until further notice

Requirements

PhD in Virology or a related field
10+ years industry or biotech experience in pre-clinical research and in vaccine technical development, with basic scientific expertise in SARS-CoV-2 research, immunology, serology, RNA vaccine technologies, and synthetic virology
Practical knowledge of global SAR-CoV-2 surveillance, recommendation, and regulatory systems
Experience providing scientific leadership for projects in the pharmaceutical industry, and proven track record of project advancement and delivery in vaccines
Global scientific reputation as evidenced by publication record and interaction with NIH or other established government research agencies
Understanding the scientific and non-scientific aspects of vaccines, and viral vaccine scientific, clinical and competitive landscape
Demonstrated innovation and experience to applying knowledge, techniques and skills to identify and validate best new technologies
Strong communication skills including public speaking experience and scientific writing
Experience collaborating cross functionally
Scientific analysis experience

Job Responsibility

Support and enhance the current infrastructure and processes required to enable robust and rapid development and licensure of variant-adapted COVID-19 vaccines
Represent Research on the cross-functional Vaccine Product Team, operating at the interface between research and development and coordinating with non-research functions to meet program goals, including life cycle management
Establish relationships with and serve as a primary scientific liaison with external alliance partners, including collaborating companies, government agencies and non-governmental organizations
Actively manage project risks, devising and implementing appropriate mitigation activities with multidisciplinary teams
Lead timely and effective communication of project risks and impact to senior leaders
Ensures that intellectual property is appropriately obtained and safeguarded
Take a key role in communication about vaccine programs in internal Pfizer documents and external patent applications, regulatory submissions, scientific papers, and conferences
Leads a motivated, committed and engaged research team to provide preclinical data to support annual strain change activities as well as exploration of next-generation vaccine technologies, leading direct reports and non-reports, reviewing experimental designs and data

What we offer

eligibility for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary
eligibility to participate in our share based long term incentive program
401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
paid vacation, holiday and personal days
paid caregiver/parental and medical leave
health benefits to include medical, prescription drug, dental and vision coverage
Relocation Support Available

Fulltime

Senior Director – BioIntelligence

The AI & Data for Engineered Biologics (AIDE) organization at Amgen is seeking a...

Location

United States , Thousand Oaks

Salary:

239775.00 - 295217.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree in Computational Biology, Machine Learning, Bioinformatics, Computer Science, Biophysics, or related field and 5 years of experience applying machine learning or computational modeling to biological systems
OR Master’s degree in Computational Biology, Machine Learning, Bioinformatics, Computer Science, Biophysics, or related field and 9 years of experience applying machine learning or computational modeling to biological systems
OR Bachelor’s degree in Computational Biology, Machine Learning, Bioinformatics, Computer Science, Biophysics, or related field and 11 years of experience applying machine learning or computational modeling to biological systems
At least 5 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources

Job Responsibility

Lead the BioIntelligence Team within our Large Molecule Discovery organization, defining strategy and priorities for AI-driven biologics modeling
Develop and execute a roadmap for machine learning and AI approaches that accelerate engineered biologics discovery
Align BioIntelligence capabilities with broader Research and Large Molecule Discovery priorities
Oversee development of predictive models for key biologics properties, including developability, stability, manufacturability, and immunogenicity
Advance modeling approaches using modern AI techniques such as: protein language models
generative modeling and inverse folding
representation learning
active learning and Bayesian optimization
Guide the use of multimodal biological datasets including sequence, structure, and experimental assay data
Lead development of production-quality research software and deployable ML models used across discovery teams

What we offer

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible

Fulltime

Director, Insights and Analytics

The Director, Insights & Analytics will lead the development of Cabaletta’s comm...

Location

United States , Philadelphia

Salary:

Not provided

Cabaletta Bio Inc

Expiration Date

Until further notice

Requirements

Bachelor’s degree in life sciences, business, marketing, or a related field
advanced degree (MBA, PharmD, MS) preferred
8 years of experience in pharmaceutical/biotech insights, analytics, or commercial strategy
Experience in rare disease, immunology, autoimmune disease, or cell therapy strongly preferred
Demonstrated expertise in: Primary market research
Competitive intelligence
Forecasting and market modeling
Strategic analytics
Strong ability to translate complex scientific and market data into strategic insights
Exceptional communication and executive presentation skills

Job Responsibility

Build and operationalize Cabaletta’s insights & analytics function from the ground up, including defining the operating model, selecting tools and vendors, and establishing repeatable processes for insight generation and decision support
Develop and lead Cabaletta’s commercial insights and analytics strategy across priority autoimmune indications
Translate market data, physician insights, and treatment dynamics into actionable recommendations for leadership
Provide decision support to the Chief Business Officer and executive leadership team on portfolio strategy, indication prioritization, and commercialization planning
Design and execute primary market research with key stakeholders including physicians, payers, patients, and advocacy groups
Generate insights on diagnostic pathways, treatment algorithms, unmet needs, and adoption drivers across autoimmune diseases
Partner with clinical and medical teams to ensure commercial insights inform trial design, endpoints, and value propositions
Establish and lead a competitive intelligence capability across autoimmune cell therapy, biologics, and emerging modalities
Monitor scientific, clinical, regulatory, and commercial developments in competing programs
Deliver executive-level competitive insights to inform strategic positioning and launch planning

What we offer

health and retirement
PTO
stock option plans

Senior Director Immunology

SAB Biotherapeutics

Location:
United States , Sioux Falls

Category:
Research and Development

Contract Type:
Not provided

Salary:

Job Description:

Job Responsibility:

Requirements:

Additional Information:

Job Posted:
January 26, 2026

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