Senior Data Scientist – Perturbation Biology

We are seeking a highly qualified and motivated Senior Data Scientist with a strong background in computational biology to join the Bioinformatics Technologies team within Amgen’s Automation, Research Data Systems, Informatics, and AI (ARIA) organization. ARIA is a multidisciplinary group embedded within Amgen’s discovery engine, leveraging advancements in digital technologies for disease modeling and digital modality engineering to accelerate the pipeline from target inception through drug development. Within ARIA, Bioinformatics Technologies serves as an innovation hub for developing, deploying, and applying emerging digital technologies in computational biology to drive the next generation of therapeutic discovery. Perturbation screening is an essential approach for understanding how genetic and non-genetic changes impact cellular systems. By systematically probing gene function and network dependencies, these studies reveal disease mechanisms, identify novel therapeutic targets, and uncover biomarkers that can guide preclinical and translational research. This capability enables more confident target validation and accelerates the path from discovery to therapeutic hypothesis generation. In this role, you will develop and apply advanced computational and AI/ML methods to analyze perturbation screening data, strengthen data interpretability, and collaborate with experimental teams to ensure computational predictions translate into actionable insights for target and therapeutic discovery.