Senior Bioinformatics Scientist Jobs

Signify Technology

Location:
United States, San Francisco

Category:
IT - Software Development

Contract Type:
Not provided

Salary:

170000.00 - 190000.00 USD / Year

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Job Description:

Job Advert: Senior Bioinformatics Scientist. Our client is an emerging leader within biotechnology, headquartered in the vibrant tech hub of San Francisco, California. Their mission is to empower scientists worldwide by accelerating biotech research through innovative DNA sequencing and analysis tools. Every day, thousands of innovators—including Nobel Prize winners, biotech startups, and research labs—rely on their solutions to drive world-changing discoveries in healthcare, sustainability, and beyond. In 2024, they saved researchers 2 million hours, transforming their productivity. Join their dynamic, collaborative team to shape the future of science.

Job Responsibility:

Designing and optimizing high-performance bioinformatics pipelines for processing thousands of daily samples, leveraging tools like Snakemake and cloud deployments
Innovating sequence analysis workflows for bulk/single-cell RNAseq, differential gene expression, and large-scale genomics, ensuring robust and scalable solutions
Troubleshooting complex sequencing data challenges, from biological artifacts to platform-specific issues, to ensure reliable outputs
Developing intuitive web tools (e.g., Streamlit, R Shiny) and data visualizations to transform raw bioinformatics data into actionable insights
Providing thought leadership and mentoring junior team members, fostering a culture of innovation and collaboration
Staying ahead of industry trends, integrating emerging bioinformatics tools to enhance our offerings for biopharma and research clients

Requirements:

PhD in Biological Sciences, Bioinformatics, Computational Biology, or related field, with 3+ years of experience developing production-level bioinformatics pipelines
Deep expertise in analyzing bulk/single-cell RNAseq data and performing differential gene expression using state-of-the-art tools
Significant experience building production-level Snakemake (or Nextflow) pipelines, with local and cloud-based deployments
Strong knowledge of sequence analysis (alignment, assembly) and molecular biology, with experience in Oxford Nanopore and Illumina sequencing
Proficiency in Python (numpy, pandas, Jupyter, Biopython) and package management (e.g., Conda)
Hands-on experience with Docker, Apptainer, or Singularity for containerized workflows
Expertise in Git/GitHub and Linux shell scripting for version control and automation
Proficiency in developing intuitive web tools for bioinformatics reporting (e.g., R Shiny, Streamlit)
Familiarity with public genomic data repositories (e.g., NCBI, Ensembl) and large-scale genomic data processing
Strong communication skills and ability to write clean, maintainable, production-ready code

Nice to have:

Experience with compiled languages (C++, Rust) for performant software development
1+ year of molecular biology wet lab experience
Demonstrated ability to develop novel bioinformatics algorithms
Strong interest in creating intuitive data visualizations for scientific insights

What we offer:

Competitive Compensation: Highly competitive remuneration
Generous Time Off: 4 weeks paid time off + 10 paid holidays
Comprehensive Health Coverage: Health, dental, and vision insurance, plus life insurance and mental health coverage
Retirement and Wellness: 401(k) with matching, Health Advocate services, and gym membership
Impactful Work: Contribute directly to accelerating biotech research, supporting novel therapies and sustainability
Innovative Environment: Work with cutting-edge tools (e.g., Snakemake, Streamlit, AWS) and collaborate with top-tier researchers
Supportive Culture: Join a passionate, inclusive team that values creativity, mentorship, and professional growth

Additional Information:

Job Posted:
December 12, 2025

Employment Type:

Fulltime

Work Type:

Hybrid work

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Senior Bioinformatics Scientist