Scientist

Scientist - Small Molecule Technology

Develop safe, robust, scalable, and efficient manufacturing processes for interm...

Location

India , Chennai

Salary:

Not provided

Pfizer

Expiration Date

Until further notice

Requirements

Ph.D in the field of Organic Chemistry
Demonstrated capabilities and experience in performing chemical reactions, structure characterizations, basic understanding of chromatography, Crystallizations, Basic safety principles, Basic quality principles, basic understanding of analytical techniques
Experience and demonstrated competencies in working with teams in a matrixed organization, building and nurturing relationships and effective engagement resulting in successful outcomes
Candidate should have skill in preparing the technical reports and adherence to compliance.

Job Responsibility

Develop safe, robust, scalable, and efficient manufacturing processes for intermediate and Active Pharmaceutical Ingredients (APIs) suitable for both pilot plant and commercial scale production
Performing literature search and identifying various synthetic routes for process development
Promotes the use of novel experimental approaches within sub-function
routinely investigates/creates innovative processes, hypotheses and methodologies
Knowledge of interpretation of structures using spectral techniques like NMR, IR & Mass spectra
Planning and Performing experiments as per process governance (Lab feasibility, Optimization, Pre-validation, CPP and Validation)
Performing What if studies, stress studies, holding time studies, Mass balance, recovery studies and scale up studies
Encountering the process challenges on time and supporting production teams for scale up activities
Handling of business critical / supply chain critical related investigational projects on fast track
Participate in brainstorming activity for the project in identifying scope of improvement

Fulltime

Process Development Sr Associate

Support the development, characterization and scale up of cell culture and prote...

Location

United States , Thousand Oaks

Salary:

96605.00 - 119055.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Master's Degree in Biotechnology, Bioengineering, Microbiology or related field and completion of a university-level course, research project, internship, thesis, or one year of experience in the following: Cell culture principles, cell metabolism profiles, protein chromatography, filtration and UF/DF operations to perform small scale bioprocess experiments that encompass both upstream (cell culture) and downstream (purification) operations
Experience with mammalian cell culture to maintain and scale up cell culture in shake flasks, culture bags and bench top bioreactors
Experience with purification operations to run bench-top chromatography columns to generate purified antibody product
Identify and solve problems by applying scientific and engineering principles
Design of experiments and statistical analysis of data and programming in JMP, R, or Python environments
Experience with automation efforts to enable high throughput technologies for accelerated process development

Job Responsibility

Support the development, characterization and scale up of cell culture and protein purification operations to enable commercial manufacturing advancement by conducting experiments, analyzing data, and documenting results
Work closely with senior scientists and engineers to implement process improvements
Support development of early phase cell culture, recovery and purification processes for Amgen's large molecule expansion through production bioreactor, harvest, clarification, chromatography, and/or filtration technologies as well as completing virus clearance studies
Identify, develop and implement solutions to practical problems through application of fundamental scientific and engineering principles

What we offer

stock
retirement
medical insurance
life insurance
disability insurance
eligibility for an annual bonus
health and welfare plans
financial plans with opportunities to save towards retirement or other goals
work/life balance
career development opportunities

Fulltime

Manager, Technical Marketing CDMO

Drive growth at the intersection of science, strategy, and innovation! In Alfasi...

Location

Italy , Milano

Salary:

Not provided

Alfasigma

Expiration Date

Until further notice

Requirements

MSc or PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biotechnology, or related field
5–10 years experience in a CDMO, pharma, or biotech environment
Proven exposure to: Drug Product development and manufacturing processes, Technical customer interactions, Marketing, BD, or technical-commercial roles
Experience in one or more areas: Small molecules, biologics, peptides, or advanced modalities, Development, tech transfer, scale‑up, or commercial manufacturing
Strong understanding of CMC concepts and pharmaceutical lifecycle
Ability to quickly learn and position complex technologies
Value‑based selling mindset
Excellent storytelling and presentation skills
Customer‑centric approach with ability to tailor messaging
Strong written and verbal communication (English required)

Job Responsibility

Develop and maintain technical marketing materials (capability decks, product dossiers, white papers, case studies, videos, website content)
Translate complex CMC, manufacturing, and development capabilities into customer‑focused messages
Work closely with MSAT, R&D, Regulatory, Manufacturing, and Quality teams to ensure accuracy and consistency of content
Support positioning of services across drug substance, drug product, development, scale‑up, and commercial manufacturing
Partner with Business Development to support: Lead qualification and opportunity shaping, Customer presentations and technical pitches, RFI/RFP/RFQ technical inputs
Prepare customized customer‑specific value propositions aligned with development stage and therapeutic needs
Participate in customer meetings, scientific discussions, and technical calls as needed
Monitor CDMO market trends, competitor positioning, and emerging technologies
Analyze customer needs by modality, therapeutic area, and development phase
Provide insights to support portfolio strategy, investment decisions, and differentiation

What we offer

competitive salary
comprehensive benefits
extensive opportunities for professional growth and development

Fulltime

Process Development Senior Associate

At Amgen, if you feel like you’re part of something bigger, it’s because you are...

Location

United States , Cambridge

Salary:

85306.00 - 103484.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Master’s degree or (foreign equivalent) in Chemical Engineering, Bioengineering, Analytical Chemistry, Biochemistry or a related field & completion of a university-level course, research project, internship, thesis, or one year of experience in the following: 1. Analytical chemistry experience for small molecules, and completion of project deliverables including: designing and conducting targeted metabolomics experiments, extracting and analyzing results via dedicated software: ChemStation, MassHunter, or MassAnalyzer
2. Analytical method development (chromatography and mass spectrometry), related technologies and instrumentation including: U/HPLC, GC, or LC-MS
3. Method qualification and transfer for analytical instruments, along with data analysis and statistical evaluation of experimental results
4. Application analytical instrument troubleshooting across different platforms: Waters, Agilent, or Sciex, and problem solving of such technologies
5. Implementing Standard Operating Procedures in a laboratory environment in accordance with GLP standards
and 6. Maintaining a laboratory notebook.

Job Responsibility

Conduct experiments, analyze results, and implement process improvements to enhance efficiency and product quality
Design, develop, and optimize manufacturing processes
Collaborate closely with a team of analysts and scientists
Responsible for the technical aspects of developing analytical tools to gain understanding of quality attributes in product and process for late phase synthetic small molecule, synthetic peptide, and siRNA programs
Utilize platform and in-depth product attribute knowledge to advance Amgen products and ensure success through pivotal clinical phases to marketing authorization application
Develop, optimize, and execute analytical methods for synthetic small molecules, synthetic peptide, and SiRNA release testing and process characterization
Collaborate closely with drug substance process development team to achieve project objectives and provide analytical data to support drug substance product development.

What we offer

stock
retirement
medical
life and disability insurance
eligibility for an annual bonus
Retirement and Savings Plan with generous company contributions
group medical, dental and vision coverage
life and disability insurance
flexible spending accounts
discretionary annual bonus program

Fulltime

Director of Discovery Pharmacology

As Director of Discovery Pharmacology, the main responsibility will be leading i...

Location

Sweden , Stockholm

Salary:

Not provided

Life Science Talent

Expiration Date

Until further notice

Requirements

PhD in pharmacology, biochemistry, cell biology or related discipline
Strong hands-on background (≥ 15 years) in a biotech or pharmaceutical setting
Experience in fibrotic disease biology with preference for background in the context of lung and/or kidney disease
Experience developing and interpreting cell-based and biochemical assays supporting small-molecule programs
Solid understanding of GPCR signalling, functional pharmacology and assay technologies
Experience working with CROs and managing outsourced biological work including in vivo study monitoring
Ability to translate complex biological data into clear project recommendations
Excellent written and verbal communication skills
Comfortable working in a small, agile, clinical-stage organization with a virtual R&D setting

Job Responsibility

Non-clinical team member for discovery-stage programs serving as biology and pharmacology expert in cross-functional discovery projects
Define biological hypotheses, assay cascades and decision criteria aligned with project goals and medicinal chemistry strategy
Design and implement robust in vitro and in vivo biological assays to assess disease-related mechanisms, ensuring scientific rigor and suitability for compound screening and characterization
Develop, validate, and optimize cell-based and biochemical GPCR assays (e.g. signalling, functional, pathway-specific readouts)
Oversee assay and study execution at CROs, including protocol development, troubleshooting, data quality review and timeline management
Support compound profiling, selectivity assessment, and mechanism-of-action studies, including pathway bias and functional pharmacology where relevant
Contribute to the development and execution of tissue-based disease models and in vivo disease models, working together with internal team members and external partners
Analyse and synthesize complex biological datasets to support compound prioritization and progression decisions
Contribute biological expertise to interactions with internal non-clinical, clinical, regulatory and IP functions as needed
Lead translational biomarker strategy and support identification, validation and implementation of pharmacodynamic and disease-relevant biomarkers to enable target engagement assessment and clinical translation

What we offer

Competitive compensation, benefits, and the opportunity to grow professionally in a collaborative environment where your expertise will be highly valued

Fulltime

Provide training, troubleshooting, and oversight of high performance liquid chro...

Location

United States , Cambridge

Salary:

151674.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Master’s degree in Chemistry, Biochemistry, Analytical Chemistry, or related field and 3 years of experience in the job offered or in a chemistry-related occupation
Developing, executing, and troubleshooting analytical test methods utilizing high performance liquid chromatography
Qualifying and transferring analytical test methods following pharmaceutical industry guidelines
Operation and data analysis with chromatography data software such as Waters Empower, Agilent Chemstation, or OpenLab
Investigating out of trend and out of specification analytical test results
Training analysts on the operation of high-performance liquid chromatography equipment and the interpretation of chromatography data for biological and small molecule drug candidates
Executing analytical tests in accordance with the United States or international pharmacopoeia.

Job Responsibility

Provide training, troubleshooting, and oversight of high performance liquid chromatography (HPLC) analyses
Analyses include size-exclusion, cation and anion exchange, affinity, and reversed phase high performance liquid chromatography and/or ultra high performance liquid chromatography (UHPLC)
Perform hands-on testing support of the HPLC/UHPLC methods
Implement new HPLC/UHPLC methods including, drafting test method standard operating procedures, performing familiarization runs, and documenting method establishment in method transfer reports
Perform and trend assay control charts to monitor the performance of all HPLC/UHPLC testing
Interface with analytical method developers and team leads on method performance
Perform technology development to improve the speed and compliance
Qualify HPLC/UHPLC methods to enable transfer of methods to a quality control laboratory
Collaborate with partner organizations during commercial process development, process characterization, and process validation studies to support marketing applications
Supervise direct reports

What we offer

stock
retirement
medical
life and disability insurance
annual bonus
flexible work models including remote and hybrid work arrangements

Fulltime

Senior Analytical Scientist/ Investigator

We are looking to fill a new Senior Analytical Scientist/ Investigator position ...

Location

Singapore , Tuas

Salary:

Not provided

GSK

Expiration Date

Until further notice

Requirements

At least a degree in Pharmacy, Chemistry, Pharmaceutical Sciences, Biochemistry/ Biotechnology, Biomedical Engineering or equivalent
Extensive hands-on experience in an analytical environment, preferably in the pharmaceutical industry with understanding of GMP and GLP requirements or equivalent
Prior experience in analytical technologies for the analysis and characterization of small molecules, biologics or vaccines is preferred
Hands-on experience, skilled in the execution, optimization and trouble-shooting in one or more of the following analytical techniques is preferred: Chromatographic techniques (2D-ULPC, HPLC-CAD, SEC-MALS), real time multi-angle light scattering (RT-MALS), analysis of biomolecular interactions by bio-layer interferometry (BLI), fluorescence-based assays, spectrophotometric techniques and colorimetric assays, dynamic light scattering (DLS), protein content by Lowry assay, nucleic acid content determination by fluorometry
Basic knowledge of drug substance and/ or drug product manufacturing processes for vaccines products is preferred
Enjoy working in a laboratory environment and thrive in activities and tasks related to analytical method development, troubleshooting, optimization, problem solving and root cause analysis under time pressure, to meet business needs and project implementation timelines
Excellent inter-personal communication skills, proactive with leadership skills, data-driven decision making, project management and stakeholder management skills with the experience and ability to work in cross-functional and global teams (across R&D, quality and global analytical hubs)
Possess a continuous improvement mindset and be able to lead improvement initiatives

Job Responsibility

Analytical Leadership and Innovation: Spearhead the full spectrum of analytical activities, including setting up advanced equipment, analytical method technology transfer and optimization, non-routine characterization and comparability assessments of drug substances and intermediates to support development and commercial manufacture of new vaccines products
Data-Driven Insights and Recommendations: Pro-actively generate and interpret comparability data of drug substances/ intermediates as part of material and process changes/ improvements to drive high impact, data-driven recommendations for the development and optimization of manufacturing processes
Problem-Solving and Root Cause Analysis: Lead laboratory investigations and trouble-shooting related to analytical equipment, methods and out-of-trend results, ensuring timely resolution with effective corrective and preventive actions
Development of Robust Analytical Strategies: Review and improve analytical methods, procedures and standards in accordance with pharmacopoeia requirements and in-house analytical technical standards
Analytical Equipment Stewardship: Qualification and lifecycle maintenance (including preventive maintenance/ calibration and performance verification checks) of equipment to appropriate analytical standards
Lifecycle Data Management: Ensure thorough, complete and accurate documentation of all laboratory procedures and data
Champion for Laboratory Safety and Sustainability: Lead/ support environmental health, safety and sustainability activities for the laboratory
Mentorship and Development: Supervise, train and develop interns and junior scientists

What we offer

Competitive base salary
Annual bonus based on company performance
Flexible working options available for most roles
Learning and career development
Access to healthcare & wellbeing programmes
Employee recognition programmes

Fulltime

Associate Research Scientist – Protein Mass Spectrometry

We are looking for a highly motivated Associate Research Scientist with demonstr...

Location

Canada , Vancouver

Salary:

61600.00 - 77000.00 CAD / Year

AbCellera Biologics

Expiration Date

Until further notice

Requirements

MSc in Analytical Chemistry, Biochemistry, or a related field, or a BSc with 3+ years of relevant wet lab experience in an academic or industry setting
Hands on experience preparing and analyzing organic compounds, metabolites, or other ADC-related small molecules using LC-MS workflows
Experience with analytical and scientific software such as Chromeleon, TraceFinder, Compound Discoverer, ChemDraw, Prism
Hands on experience operating LC-MS instrumentation including QQQ, Q-TOF, or Orbitrap MS systems
Able to implement methods for high throughput sample preparation and automated data analysis, and have experience in method qualifications and drafting SOPs
Experience with other small molecule analytical techniques such as NMR or IR Spectroscopy
Think critically, are curious, and want to explore new technologies and opportunities to improve antibody characterization workflows and processes
Creative problem solver and fast learner who believes in team work to tackle the most challenging scientific problems
Great interpersonal skills, and thrive in a collaborative working environment as a member of cross-functional team
Excellent documentation, organizational, and communication skills, impeccable attention to detail, and an ability to analyse and interpret large datasets

Job Responsibility

Performing LC-MS methods for quantitation and characterization of small molecule compounds and/or antibodies or other proteins
Evaluating and recording performance metrics for LC-MS platforms and assays
Documenting results in an ELN and communicating across a matrix team
Assisting with various analytical laboratory activities, including compound inventory, LC-MS instrument operation, maintenance, and troubleshooting
Assisting with assay development, including method validation and optimization
Performing routine and advanced bioanalytical assays to support in vitro activities
Developing and implementing standard operating procedures
Organizing, supporting, and collaborating with team members to meet project deliverables and timelines

What we offer

Equity
Annual bonus dependent on team and company performance
6% (non-match) RRSP contribution
CAD $1,500 annual Active Lifestyle Allowance
Annual vacation
Professional development opportunities
Comprehensive health benefits
Scientific and technical mentorship

Fulltime

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Scientist - Small Molecule Technology

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