Scientist - Small Molecule Technology Job at Pfizer (Chennai)

New

Scientist - Small Molecule Technology

Develop safe, robust, scalable, and efficient manufacturing processes for interm...

Location

India , Chennai

Salary:

Not provided

Pfizer

Expiration Date

Until further notice

Requirements

Ph.D in the field of Organic Chemistry
Demonstrated capabilities and experience in performing chemical reactions, structure characterizations, basic understanding of chromatography, Crystallizations, Basic safety principles, Basic quality principles, basic understanding of analytical techniques
Experience and demonstrated competencies in working with teams in a matrixed organization, building and nurturing relationships and effective engagement resulting in successful outcomes
Candidate should have skill in preparing the technical reports and adherence to compliance.

Job Responsibility

Develop safe, robust, scalable, and efficient manufacturing processes for intermediate and Active Pharmaceutical Ingredients (APIs) suitable for both pilot plant and commercial scale production
Performing literature search and identifying various synthetic routes for process development
Promotes the use of novel experimental approaches within sub-function
routinely investigates/creates innovative processes, hypotheses and methodologies
Knowledge of interpretation of structures using spectral techniques like NMR, IR & Mass spectra
Planning and Performing experiments as per process governance (Lab feasibility, Optimization, Pre-validation, CPP and Validation)
Performing What if studies, stress studies, holding time studies, Mass balance, recovery studies and scale up studies
Encountering the process challenges on time and supporting production teams for scale up activities
Handling of business critical / supply chain critical related investigational projects on fast track
Participate in brainstorming activity for the project in identifying scope of improvement

Fulltime

New

Senior Principal Scientist, Pre-Formulation and Materials Science

This Senior Principal Scientist position will be a strong scientific and leaders...

Location

United States , La Jolla

Salary:

120800.00 - 201400.00 USD / Year

Pfizer

Expiration Date

Until further notice

Requirements

PhD in Pharmaceutics, Pharmaceutical Sciences, Materials Science, Physical Chemistry, Physical Organic Chemistry, Biophysical Chemistry or related discipline with 10+ years relevant experience in drug delivery
BS/MS in Pharmaceutics, Pharmaceutical Sciences, Materials Science, Physical Chemistry, Physical Organic Chemistry, Biophysical Chemistry or related discipline with a minimum of 10-12 years relevant pharmaceutics industry experience in small molecule drug product design
Knowledge in biology/pharmacology/drug discovery /drug delivery up to Proof of Concept (POC) studies
Small molecule Formulation and/or early Biopharmaceutics, Materials Science, or Pharmacokinetics background
Experience in using and interpreting biophysical modeling, physicochemical (solubility & dissolution) and biological (passive, transporter mediated, efflux) transport phenomena, design, interpretation, and use of in vitro experiments, or in vivo/in vitro drug metabolism studies, and interpretation of pre-clinical exposure data for the design and selection of new small molecule drug candidates and drug delivery systems
A strong interest and motivation to learn and implement new technologies and concepts
A strong interest in leadership
Extensive practical experience working within cross-disciplinary teams and achieving results in a matrix environment
Excellent organizational and communication (oral and written) skills
The ability to work independently, as well as collaboratively

Job Responsibility

Provide scientific advances, leadership, and strategic direction for the fundamental understanding of key connectivity of molecular structure, solution and diffusion behavior and permeation characteristics to enable optimal drug formulation and drug delivery systems design
Integrates pharmaceutics, physical organic chemistry, biophysical chemistry, supramolecular chemistry, materials science, and fundamental biopharmaceutics principles into drug candidate screening and design, formulation design, solid form strategy, and ultimately project direction
Teach and mentor colleagues across the Pfizer organization
Cultivates sustainable and effective relationships with internal partners and stakeholders
Advances scientific research and expands capability in the areas of molecular design-drug delivery, materials science, early biopharmaceutics, and drug formulation

What we offer

Eligibility for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary
Eligibility to participate in our share based long term incentive program
401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage
Relocation support available

Fulltime

Principal Scientist – Synthetic Separations

Amgen is seeking a highly motivated Senior Principal Scientist for their Discove...

Location

India , Hyderabad

Salary:

Not provided

Amgen

Expiration Date

Until further notice

Requirements

Ph.D. in Chemistry, Analytical Chemistry, or related field with 8+ years of relevant experience, or M.S. with 12+ years of relevant experience in analytical or discovery chemistry within the biopharmaceutical industry
PhD in Analytical Chemistry or a related discipline with 8+ years of relevant industry experience in chromatographic analysis and/or purification of small molecules within a pharmaceutical R&D environment
Minimum of 5 years in a leadership or people management role
Develop, optimize, and implement analytical methods (LC, LC/MS, GC, SFC, NMR, HRMS, and related techniques) for purity assessment, structural confirmation, quantitative analysis, and reaction monitoring of synthetic compounds
Develop, optimize, and implement analytical methods (LC, LC/MS, GC, SFC, NMR, etc.) for purity assessment, structural confirmation, and reaction monitoring of synthetic compounds
Design, qualify, and maintain high-throughput or automated analytical workflows to support medicinal chemistry cycles
Collaborate with cross-functionally digital and automation groups to enable data-driven analytics and AI-supported structure prediction
Drive continuous improvement in analytical workflows and laboratory efficiency through process automation and robotics
Excellent written and verbal communication skills
Prepare concise, high-quality reports and presentations for internal review and external disclosure

Job Responsibility

Lead analytical strategy and execution for drug discovery-stage projects, enabling medicinal chemistry and early candidate selection through deep expertise in analytical and separation sciences
Bridge synthetic and analytical chemistry, ensuring rapid, reliable characterization of novel compounds and intermediates that drive Amgen’s small molecule discovery pipeline
Lead and manage the Synthetic Separations group, providing strategic direction, technical leadership, and mentorship to staff while prioritizing workloads, optimizing team performance, and serving as both a people manager and subject matter expert in synthetic separations
Design and qualify automated workflows enabling rapid turnaround and consistent data quality for purification and analysis of diverse compound libraries
Utilization of a diverse set of instruments and technologies, such as (but not limited to) HPLC, SFC, MS, mass-directed purification, and preparative-scale SFC and LC is necessary
Lead library purification efforts across multiple scales, ranging from microgram-level purification of screening compounds to hundreds of milligrams for advanced characterization
Assist in research efforts directed at improving process efficiencies, expanding the range of assays and applications, building state-of-the-art analytical capabilities, and improving technologies and infrastructure

New

Senior Principal Scientist, Technical Operations

The Senior Principal Scientist will serve as the technical authority and strateg...

Location

United States

Salary:

175000.00 - 230000.00 USD / Year

Loyal

Expiration Date

Until further notice

Requirements

Ph.D. in Material Science, Chemical Engineering, or related physical science
10+ years of industry experience in preferably small molecule oral solid dosage formulation development, with demonstrated ownership of drug product strategy through clinical stage development
Proven experience leading development of novel molecular entities
Significant experience selecting, managing, and overseeing CDMOs for formulation development, technical transfer, scale-up, and GMP manufacturing
Deep expertise in preferably small molecule oral tablet formulation, process development, compaction fundamentals, and manufacturing science
Demonstrated experience authoring and defending CMC regulatory submissions
Significant hands-on experience designing and executing statistically sound development programs using DoE and data-driven decision frameworks
Experience supporting technical diligence and external partnership evaluations
Demonstrated ability to operate effectively in a dynamic, fast-paced startup environment

Job Responsibility

Own and lead the end-to-end drug product development strategy, including pre-formulation, formulation development, scale-up, and clinical manufacturing
Serve as the technical lead for all drug product activities with CDMOs, including selection, oversight and troubleshooting
Provide strategic guidance on raw material sourcing, manufacturability, product quality risk assessments, and lifecycle management considerations
Identify and proactively mitigate technical, regulatory, and supply risks
develop contingency strategies to ensure program continuity
Author, review, and approve drug product CMC sections for regulatory submissions (IND/CTA and amendments), and represent Drug Product CMC in regulatory agency interactions
Lead technical due diligence efforts, including CDMO evaluation, proposal review, data integrity assessments, and master batch record approval
Establish and implement robust experimental strategies, including design of experiments (DoE), to optimize formulation and process development
Mentor and provide scientific leadership to internal team members and consultants
elevate organizational capabilities in drug product development

What we offer

Full-coverage health insurance — medical, dental and vision — for you and your dependents
$1,000 home office equipment stipend
$1,200/year learning budget for books, courses, etc.
$250/month wellness budget for gym, cleaners, spa, food, etc.
All 3-day weekends are turned into 4-day weekends
Unlimited vacation and paid holidays
Paw-ternity leave — adopt a dog and get a day off with your new family member
Competitive salary
Company equity options grant for new hires

Fulltime

New

R&D Formulation Scientist

The Formulation Scientist under the direction of Process Development Director is...

Location

Spain , Leon

Salary:

Not provided

PCI Pharma Services

Expiration Date

Until further notice

Requirements

Master’s degree in pharmaceutics or a related scientific discipline
At least 5 years’ experience in formulation development of product formulations in solution, suspension, emulsion and lyophilized forms for small molecules and biological products, defining QTPPs and CQAs, selecting suitable form of API and designing characterization studies, compatibility, solubility, dissolution, physico-chemical stability, etc.
Good level of spoken English and Spanish
Very good written communication skills

Job Responsibility

Development of product formulations in solution, suspension, emulsion and lyophilized forms for small molecules and biological products (mAb: monoclonal antibodies
ADC: antibody drug conjugate
proteins, peptides, oligonucleotides and high potency products)
Define and update the QTPPs and CQAs of the formulation: efficacy, safety, stability, purity and potency, etc.
In partnership with the client aid in the selection of suitable form of API for final drug product through pre-formulation and formulation techniques e.g. polymorph, isomeric conformation, melting point, hygroscopicity, pH and logP, particle size
Evaluation and selection of excipients according to QTTP. Selection and concentration of the formulation excipients and definition of the CMA of the selected excipients
Design of tests to evaluate the behavior of excipients and APIs: characterization studies, compatibility, solubility, dissolution, physico-chemical stability, etc.
Application of DoE methodology to design, perform and analyze laboratory scale experiments for the optimization of formulations and their manufacturing processes
Selection, design and execution of supporting studies and documentation for the development of the project: general studies such as characterization, compatibility, robustness, stability, etc. and specific biological products studies such as freeze-thaw, shear stress, protein content, silicone compatibility, etc.
Selection of appropriate equipment, manufacturers and technologies for technical and manufacturing transfer. Perform tasks related to pre-clinical batches, including toxicological studies

What we offer

Competitive salary
Health insurance + reimbursement for medication
English classes
Discounts on various activities
Partnerships with gyms
Referral programme

Fulltime

Senior Scientist - Downstream Analytics

Senior Scientist – Downstream Analytics (Large Molecules). We’re partnering with...

Location

United Kingdom , Southampton

Salary:

45000.00 - 55000.00 GBP / Year

Cranleigh STEM

Expiration Date

Until further notice

Requirements

A PhD (or equivalent experience) in Analytical Chemistry, Biochemistry, or a related field
Strong hands-on experience in HPLC and bioprocessing within a biotechnology, pharmaceutical, or life sciences environment
Knowledge of purification and characterisation methods for peptides, antibodies, or similar large molecules
Experience with TFF or tangential flow filtration (advantageous)
Familiarity with ISO or GMP-regulated environments
Ability to lead technical projects and support team development
Strong communication and problem-solving skills
A flexible, proactive mindset with strong attention to detail

Job Responsibility

Lead downstream analytical workflows using HPLC, UPLC, PAGE, flash chromatography, and related techniques
Contribute to the purification and characterisation of large molecules, such as peptides and antibodies
Support method development and continuous improvement in analytical approaches
Collaborate with chemistry and production teams to support small molecule and oligonucleotide preparation
Maintain, calibrate, and optimise analytical instrumentation in line with ISO and internal quality systems
Mentor and support Associate Scientists and Lab Technicians
Ensure accurate documentation and maintain data integrity across workflows
Promote and uphold Health, Safety, and Environmental (HSE) standards
Manage stock levels of analytical reagents and consumables
Stay up to date on emerging trends in bioprocessing and analytical technologies

What we offer

Holidays: 25 days annual leave + 8 bank holidays
Pension: 6% employer contribution
Life Assurance: 4x salary
Flexible working hours
Long service awards and recognition scheme
Employee Assistance Programme with 24/7 remote GP access
Annual flu vaccinations
Cycle to work scheme and gym discounts
Discounts and savings platform
Professional membership reimbursement

Fulltime

New

In-Vivo Pharmacology Senior Research Associate / Scientist

Seeking an ambitious, curious, and detail-oriented scientist at the Senior Resea...

Location

United States , New York

Salary:

40.00 - 48.00 USD / Hour

Beacon Hill

Expiration Date

Until further notice

Requirements

Bachelor's Degree in a relevant discipline (Veterinary Technology, biology, chemistry, animal sciences, or related field) and at least 3-5 years of experience, or a master's degree and at least 2 years of relevant experience
At least 2 years of industry experience in a biotechnology/pharmaceutical company or full-time academic lab experience
Certification as a Veterinary Technician (CVT, LVT, or RVT) preferred
Expertise with oncology studies, including experience with tumor cell implantations and compound dosing, preferred
Knowledge and experience with formulation of small molecules and biologics
Strong verbal and written communication skills to effectively share scientific findings
Passion for working at the bench and in the vivarium to advance programs and solve technical challenges
Self-motivation and adaptability to evolving project priorities and responsibilities
Team-oriented, with a strong work ethic
Ability to learn new techniques for which training will be provided

Job Responsibility

Animal care and monitoring: Provide daily care and monitoring of mice, including health checks and documentation
Maintain detailed and accurate records of all procedures and animal health status
investigate adverse study events
Tumor implantations: Perform precise implantation or injection of tumor cells into mice to establish models for oncology studies
Monitor and document tumor growth and animal health
Dosing procedures: Administer compounds by all routes (i.v., i.p., s.q., p.o.) accurately and safely
Tissue harvesting: Collect blood, tumor tissue, and organs, including spleen and lymph nodes, for processing and analysis
Compliance and safety: Follow all institutional, local, and federal regulations regarding animal care and use
Adhere to safety protocols and maintain a clean and organized work environment
Meticulous electronic lab notebook documentation

Fulltime

New

In-Vivo Pharmacology Senior Research Associate / Scientist

Seeking an ambitious, curious, and detail-oriented scientist at the Senior Resea...

Location

United States , New York

Salary:

40.00 - 48.00 USD / Hour

Beacon Hill

Expiration Date

Until further notice

Requirements

Bachelor's Degree in a relevant discipline (Veterinary Technology, biology, chemistry, animal sciences, or related field) and at least 3-5 years of experience, or a master's degree and at least 2 years of relevant experience
At least 2 years of industry experience in a biotechnology/pharmaceutical company or full-time academic lab experience
Certification as a Veterinary Technician (CVT, LVT, or RVT) preferred
Expertise with oncology studies, including experience with tumor cell implantations and compound dosing, preferred
Knowledge and experience with formulation of small molecules and biologics
Strong verbal and written communication skills to effectively share scientific findings
Passion for working at the bench and in the vivarium to advance programs and solve technical challenges
Self-motivation and adaptability to evolving project priorities and responsibilities
Team-oriented, with a strong work ethic
Ability to learn new techniques for which training will be provided

Job Responsibility

Animal care and monitoring: Provide daily care and monitoring of mice, including health checks and documentation
Maintain detailed and accurate records of all procedures and animal health status
investigate adverse study events
Tumor implantations: Perform precise implantation or injection of tumor cells into mice to establish models for oncology studies
Monitor and document tumor growth and animal health
Dosing procedures: Administer compounds by all routes (i.v., i.p., s.q., p.o.) accurately and safely
Tissue harvesting: Collect blood, tumor tissue, and organs, including spleen and lymph nodes, for processing and analysis
Compliance and safety: Follow all institutional, local, and federal regulations regarding animal care and use
Adhere to safety protocols and maintain a clean and organized work environment
Meticulous electronic lab notebook documentation

Fulltime

Scientist - Small Molecule Technology

Pfizer

Location:
India , Chennai

Category:
Research and Development

Contract Type:
Not provided

Salary:

Job Responsibility:

Requirements:

Additional Information:

Job Posted:
February 20, 2026

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