Scientist/Senior Scientist, Vascular Jobs

NewLimit

Location:
United States, South San Francisco

Category:
Research and Development

Contract Type:
Not provided

Salary:

113000.00 - 171000.00 USD / Year

Save Job

Apply Position

Job Description:

NewLimit is seeking an scientist with experience in endothelial biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases. Your role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others.

Job Responsibility:

Develop functional assays and pre-clinical models to measure endothelial cell function
Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale
Measure the impact of mRNA reprogramming medicines on endothelial cell function
Engineer in vivo nucleic acid delivery methods for endothelial cells
Analyze and interpret experimental data to drive pre-clinical decision making

Requirements:

Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
Experience with primary endothelial cell isolation and functional characterization
Experience working with mouse models of endothelial cell function (e.g. kidney, cardiovascular, or cognitive disease models)
Experience with transgenic manipulation of endothelial cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)

Nice to have:

History of contributing to a drug development program at the pre-clinical or clinical development stage
Experience leading the design and execution of pre-clinical studies in mouse models
Experience with single cell genomics methods
Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)

What we offer:

Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
Meals and snacks on-site

Additional Information:

Job Posted:
December 10, 2025

Employment Type:

Fulltime

Work Type:

On-site work

View All Jobs In This Company

Job Link Share:

Scientist/Senior Scientist, Vascular