Scientist / Senior Scientist, DMPK Job at Altos Labs (San Francisco Bay Area)

Job Description

An exciting opportunity is available for an enthusiastic and highly-skilled Scientist or Senior Scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) team in the Drug Discovery and Development Sciences (3DS) department at the Bay Area Institute or San Diego Institute of Altos Labs. The successful candidate will be supporting the progression of our therapeutic programs by providing DMPK support to portfolio projects spanning diverse modalities, including small molecules, antisense oligonucleotides (ASOs), therapeutic proteins, and gene therapy. This role demands a fundamental understanding of drug metabolism, the relationship between physical/chemical properties and ADME, PK/PD/efficacy mechanisms, and the experiments required to generate and interpret the related data for high-quality decision-making.

Job Responsibility

Serve as the DMPK representative on cross-disciplinary preclinical project teams, providing strategic and data-driven DMPK guidance to advance portfolio programs
Plan, manage, and oversee ADME and PK studies executed with external CRO partners
Partner with Medicinal Chemistry to develop ADME- and PK-driven SAR strategies to optimize candidate properties and progression
Collaborate with Pharmacology and the internal DMPK bioanalysis group to design, execute, and interpret preclinical PK/PD, target engagement, and efficacy studies
Calculate the projected efficacious human dose to support IND-enabling development and regulatory submissions
Provide DMPK support to early-stage, pre-portfolio discovery programs, helping shape strategy and experimental plans
Advise and train the DMPK bioanalysis team to support internalization and implementation of select ADME assays
Stay current on emerging DMPK science and best practices through literature review and participation in relevant scientific meetings

Requirements

PhD in Chemistry, Biology, Pharmaceutical Sciences, or a related field and 3+ years of relevant work experience
Strong fundamental knowledge of DMPK and ADME
Working knowledge of ADME assays and bioanalysis, leveraged to design studies and interpret data
Ability to evaluate in vitro-in vivo correlation of drug candidates across preclinical species
Ability to generate NCA and compartmental PK models
general knowledge of mechanistic modeling concepts (e.g., PBPK)
Ability to communicate DMPK results in a timely, clear, and impactful manner to non-DMPK scientists
Exceptional organizational skills, attention to detail, time management, and ability to work independently and collaboratively
Willingness to gain new knowledge and apply it to support multiple therapeutic modalities

Nice to have

Knowledge and experience using RStudio, CDD, or similar platforms
Prior DMPK experience and expertise in one of the following: therapeutic proteins/biologics or small molecule metabolism
Experience with LC-MS for ADME and/or bioanalysis

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Scientist / Senior Scientist, DMPK

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