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Scientist, Protein Purification

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GSK

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Location:
United States , Cambridge

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Contract Type:
Not provided

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Salary:

89925.00 - 149875.00 USD / Year

Job Description:

We’re looking for an innovative and highly skilled protein biochemist to drive production, isolation, and purification of proteins that enable vaccines, biologics, and therapeutic monoclonal antibody (mAb) development. This role is central to advancing GSK’s efforts and requires a strong design-for-developability mindset to minimize CMC and clinical risks. As a technical leader, you will own the design, purification, and optimization of constructs, leveraging cutting-edge chromatography and filtration techniques to deliver high-quality protein reagents for downstream assessments. Successful candidates will drive innovation and reproducibility while collaborating across functional areas to advance GSK’s mission to deliver impactful medicines and vaccines to billions globally.

Job Responsibility:

  • Lead protein isolation, and purification pipelines to meet stringent design-for-developability standards
  • Drive optimization of protein purification protocols through hands-on expertise in chromatography techniques (affinity, ion-exchange, multimodal, hydrophobic interaction, size-exclusion chromatography) and filtration methods (tangential flow filtration and buffer exchange)
  • Actively collaborate with cross-functional teams to address complex challenges in construct design, protein behavior, and structural assessments
  • Ensure rigorous documentation and implement quality control measures to support intellectual property and enable reagent reuse
  • Regularly present project updates, purification outcomes, and next steps at internal review meetings to align stakeholders

Requirements:

  • PhD in life sciences with 0+ years of relevant experience in biotechnology
  • MS with ≥2 years' experience
  • BS with ≥4 years' experience in biotechnology-related fields
  • At least one year of hands-on protein purification experience, including chromatography (SEC, ion-exchange, affinity) and filtration (TFF, buffer exchange)
  • One or more years of experience with mammalian cell cultures (HEK293 and/or CHO cell lines) for protein expression systems
  • One or more years of experience operating and maintaining AKTA systems or equivalent platforms for protein purification
  • One or more years of experience with standard lab techniques: SDS-PAGE, western blot, molecular biology tools (cloning, PCR)

Nice to have:

  • Demonstrated expertise in advanced purification techniques, including multimodal chromatography and rigorous design strategies
  • Experience working with diverse protein expression systems (bacteria, insect, yeast) beyond mammalian cultures
  • Strong problem-solving, troubleshooting, and process optimization skills
  • Capacity to work independently, manage competing priorities, and adapt to evolving timelines while driving results
  • Strong communication skills
  • Able to efficiently manage uncertainty, changes in priority and timeline restrictions
  • Excellent oral and written communication skills with a fluency in English
What we offer:
  • Competitive base salary
  • Annual bonus based on company performance
  • Flexible working options available for most roles
  • Learning and career development
  • Access to healthcare & wellbeing programmes
  • Employee recognition programmes
  • Eligibility to participate in our share based long term incentive program
  • Health care and other insurance benefits (for employee and family)
  • Retirement benefits
  • Paid holidays
  • Vacation
  • Paid caregiver/parental and medical leave

Additional Information:

Job Posted:
March 18, 2026

Employment Type:
Fulltime
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