Scientist, Protein Purification Job at GSK (Cambridge)

Job Description

We’re looking for an innovative and highly skilled protein biochemist to drive production, isolation, and purification of proteins that enable vaccines, biologics, and therapeutic monoclonal antibody (mAb) development. This role is central to advancing GSK’s efforts and requires a strong design-for-developability mindset to minimize CMC and clinical risks. As a technical leader, you will own the design, purification, and optimization of constructs, leveraging cutting-edge chromatography and filtration techniques to deliver high-quality protein reagents for downstream assessments. Successful candidates will drive innovation and reproducibility while collaborating across functional areas to advance GSK’s mission to deliver impactful medicines and vaccines to billions globally.

Job Responsibility

Lead protein isolation, and purification pipelines to meet stringent design-for-developability standards
Drive optimization of protein purification protocols through hands-on expertise in chromatography techniques (affinity, ion-exchange, multimodal, hydrophobic interaction, size-exclusion chromatography) and filtration methods (tangential flow filtration and buffer exchange)
Actively collaborate with cross-functional teams to address complex challenges in construct design, protein behavior, and structural assessments
Ensure rigorous documentation and implement quality control measures to support intellectual property and enable reagent reuse
Regularly present project updates, purification outcomes, and next steps at internal review meetings to align stakeholders

Requirements

PhD in life sciences with 0+ years of relevant experience in biotechnology
MS with ≥2 years' experience
BS with ≥4 years' experience in biotechnology-related fields
At least one year of hands-on protein purification experience, including chromatography (SEC, ion-exchange, affinity) and filtration (TFF, buffer exchange)
One or more years of experience with mammalian cell cultures (HEK293 and/or CHO cell lines) for protein expression systems
One or more years of experience operating and maintaining AKTA systems or equivalent platforms for protein purification
One or more years of experience with standard lab techniques: SDS-PAGE, western blot, molecular biology tools (cloning, PCR)

Nice to have

Demonstrated expertise in advanced purification techniques, including multimodal chromatography and rigorous design strategies
Experience working with diverse protein expression systems (bacteria, insect, yeast) beyond mammalian cultures
Strong problem-solving, troubleshooting, and process optimization skills
Capacity to work independently, manage competing priorities, and adapt to evolving timelines while driving results
Strong communication skills
Able to efficiently manage uncertainty, changes in priority and timeline restrictions
Excellent oral and written communication skills with a fluency in English

What we offer

Competitive base salary
Annual bonus based on company performance
Flexible working options available for most roles
Learning and career development
Access to healthcare & wellbeing programmes
Employee recognition programmes
Eligibility to participate in our share based long term incentive program
Health care and other insurance benefits (for employee and family)
Retirement benefits
Paid holidays
Vacation
Paid caregiver/parental and medical leave

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Scientist, Protein Purification

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