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Conception · Research and Development

Scientist, In Vitro Gametogenesis

United States, Berkeley · Job Posted February 17, 2026
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Job Description

This is a cell culture–intensive role focused on hands-on experimentation, optimization, and analysis. You will work with mouse pluripotent stem cell lines (ESCs and iPSCs) to develop and refine in vitro gametogenesis protocols, generating robust and reproducible datasets that support translation of this work into human systems.

Job Responsibility

  • Develop and optimize methods to generate mouse iPSC lines
  • Maintain, differentiate, and engineer mouse ESC and iPSC lines using CRISPR-based tools
  • Improve and standardize differentiation protocols to derive different gonadal cell types from mouse iPSCs and/or ESCs
  • Drive experimental design, troubleshooting, and protocol development for in-vitro gametogenesis studies
  • Analyze data and communicate findings internally, contribute to overall experimental design and process standardization within the team
  • Maintain rigorous documentation, data tracking, and communication of experimental progress

Requirements

  • Proven expertise in pluripotent stem cell culture and differentiation, with demonstrated skill in maintaining stable, high-quality cultures (mouse preferred
  • human acceptable)
  • Strong foundation in developmental biology and stem cell biology, ideally in mouse systems
  • Experience with interpreting and discussing sequencing datasets (e.g., 10x scRNAseq, Smart-seq2)
  • Experience with one or more of the following is highly desirable: Immunofluorescence analysis
  • FACS sorting
  • Understanding of epigenetic regulation and developmental transitions is a plus
  • Strong scientific foundation and a track record of executing complex experiments with rigor.
  • Mission-driven mindset and enthusiasm for high-impact work
  • Excellent communication, organization, and collaboration skills
  • Meticulous attention to detail and record-keeping

Nice to have

Understanding of epigenetic regulation and developmental transitions

What we offer

  • company equity
  • excellent healthcare benefits
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